Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| SIERACKI JC et al. | Experimental aortic atherosclerosis in rabbits following the ingestion of dihydrocholesterol. | 1960 | Angiology | pmid:14446526 |
| Moraes EA et al. | Delivering cholesterol or cholestanol to bull sperm membranes improves cryosurvival. | 2010 | Anim. Reprod. Sci. | pmid:19733986 |
| Moraes EA et al. | Cholestanol-loaded-cyclodextrin improves the quality of stallion spermatozoa after cryopreservation. | 2015 | Anim. Reprod. Sci. | pmid:26005214 |
| Nusca A et al. | [Indicators of water microbial pollution: problems and perspectives]. | 2008 Nov-Dec | Ann Ig | pmid:19238878 |
| Brunnekreeft JW et al. | Direct determination of total serum cholesterol by on-column gas-liquid chromatographic analysis without previous derivatisation compared with WHO-CDC reference method. | 1983 | Ann. Clin. Biochem. | pmid:6418055 |
| Nikkilä K | Liver transplantation restores low serum levels of very low density and high density lipoproteins in end-stage primary biliary cirrhosis. | 1992 | Ann. Med. | pmid:1610540 |
| Norin E | Intestinal cholesterol conversion in adults and elderly from four different European countries. | 2008 | Ann. Nutr. Metab. | pmid:18382071 |
| Andriamiarina R et al. | Effects of stigmasterol-supplemented diets on fecal neutral sterols and bile acid excretion in rats. | 1989 | Ann. Nutr. Metab. | pmid:2516429 |
| Srikumar TS et al. | Analysis of fecal bile acids and neutral steroids using gas-liquid chromatography. | 1998 | Ann. Nutr. Metab. | pmid:9745109 |
| Valayil JM et al. | Isolation, Purification and Characterization of a Novel Steroidal Saponin Cholestanol Glucoside from Lasiodiplodia theobromae that Induces Apoptosis in A549 Cells. | 2016 | Anticancer Agents Med Chem | pmid:26338072 |