Dihydrocholesterol is a lipid of Sterol Lipids (ST) class. Dihydrocholesterol is associated with abnormalities such as Exanthema, Morphologically altered structure, protrusion, Dehydration and Xanthoma. The involved functions are known as Regulation, Biochemical Pathway, Methylation, Metabolic Inhibition and Biosynthetic Pathways. Dihydrocholesterol often locates in envelope, Mitochondria, Lipid Bilayers, Host Cell and Membrane. The associated genes with Dihydrocholesterol are GRAP2 gene, PTP4A2 gene, HSD3B7 gene, MBD2 gene and IGF2BP3 gene. The related lipids are Sterols, Cardiolipins, Pregnanes, 7-hydroxy-4-cholesten-3-one and Hydroxycholesterols. The related experimental models are Mouse Model.
To understand associated biological information of Dihydrocholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Dihydrocholesterol is suspected in Xanthoma, Xanthomatosis, Cerebrotendinous, Coronary heart disease, Exanthema, Morphologically altered structure, Dehydration and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Dihydrocholesterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'On the mechanism of accumulation of cholestanol in the brain of mice with a disruption of sterol 27-hydroxylase.' (BÃ¥vner A et al., 2010).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rodrigues JC et al. | Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis. | 2002 | Antimicrob. Agents Chemother. | pmid:11796362 |
| Urbina JA et al. | Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii. | 1997 | Antimicrob. Agents Chemother. | pmid:9210660 |
| Said J et al. | Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1. | 2010 | Antiviral Res. | pmid:20307578 |
| Midtvedt T et al. | Intestinal microbial conversion of cholesterol to coprostanol in man. Influence of antibiotics. | 1990 | APMIS | pmid:2223037 |
| Isobe KO et al. | Effect of environmental factors on the relationship between concentrations of coprostanol and fecal indicator bacteria in tropical (Mekong Delta) and temperate (Tokyo) freshwaters. | 2004 | Appl. Environ. Microbiol. | pmid:14766559 |
| Midtvedt T et al. | Establishment of a biochemically active intestinal ecosystem in ex-germfree rats. | 1987 | Appl. Environ. Microbiol. | pmid:3124742 |
| Mott GE et al. | Biochemical characterization of cholesterol-reducing Eubacterium. | 1980 | Appl. Environ. Microbiol. | pmid:6779702 |
| Sadzikowski MR et al. | Cholesterol-reducing bacterium from human feces. | 1977 | Appl. Environ. Microbiol. | pmid:335969 |
| Parker F | Normocholesterolemic xanthomatosis. | 1986 | Arch Dermatol | pmid:3096220 |
| COLEMAN DL et al. | Intestinal sterols. II. Determination of coprostanol and certain related sterols. | 1956 | Arch. Biochem. Biophys. | pmid:13292920 |