Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang CT et al. | Comparison of patterns of fecal bile acid and neutral sterol between children and adults. | 1976 | Am. J. Clin. Nutr. | pmid:793370 |
| Mastromarino A et al. | Metabolic epidemiology of colon cancer: enzymic activity of fecal flora. | 1976 | Am. J. Clin. Nutr. | pmid:793371 |
| Kay RM and Truswell AS | Effect of citrus pectin on blood lipids and fecal steroid excretion in man. | 1977 | Am. J. Clin. Nutr. | pmid:319647 |
| Lin DS and Connor WE | Fecal steroids of the coprolite of a Greenland Eskimo mummy, AD 1475: a clue to dietary sterol intake. | 2001 | Am. J. Clin. Nutr. | pmid:11451716 |
| van Faassen A et al. | Bile acids, neutral steroids, and bacteria in feces as affected by a mixed, a lacto-ovovegetarian, and a vegan diet. | 1987 | Am. J. Clin. Nutr. | pmid:3120571 |
| Huang CT et al. | Fecal steroids in diarrhea. II. Travellers' diarrhea. | 1978 | Am. J. Clin. Nutr. | pmid:345794 |
| Nair PP et al. | Diet, nutrition intake, and metabolism in populations at high and low risk for colon cancer. Metabolism of neutral sterols. | 1984 | Am. J. Clin. Nutr. | pmid:6435444 |
| Alhariri A et al. | Clinical report: A patient with a late diagnosis of cerebrotendinous xanthomatosis and a response to treatment. | 2017 | Am. J. Med. Genet. A | pmid:28590052 |
| MOSBACH EH and BEVANS M | Early pathologic and biochemical changes in rabbits fed dihydrocholesterol. | 1960 | Am. J. Pathol. | pmid:13772987 |
| IVY AC et al. | Absorption of dihydrocholesterol and soya sterols by the rat's intestine. | 1955 | Am. J. Physiol. | pmid:13268640 |