Coprosterol

Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.

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Introduction

To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coprosterol?

Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coprosterol

MeSH term MeSH ID Detail
Brain Diseases, Metabolic D001928 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Xanthomatosis D014973 17 associated lipids
Alcoholism D000437 27 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Coprosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coprosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coprosterol?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Coprosterol?

Related references are published most in these journals:

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What genes are associated with Coprosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coprosterol?

Rodent Model

Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Coprosterol

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Authors Title Published Journal PubMed Link
Peng X et al. Spatial and temporal trend of sewage pollution indicated by coprostanol in Macao Estuary, southern China. 2002 Mar. Pollut. Bull. pmid:12398399
Yu L et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12444248
Veatch SL and Keller SL Organization in lipid membranes containing cholesterol. 2002 Phys. Rev. Lett. pmid:12484857
Heller R et al. [Cerebrotendinous xanthomatosis, a treatable metabolic disorder]. 2002 Nervenarzt pmid:12486565
Antonio González Oreja J and Ignacio Saiz Salinas J Recovery simulations of grossly polluted sediments in the Bilbao Estuary. 2003 Mar. Pollut. Bull. pmid:12535968
Addona GH et al. Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site. 2003 Biochim. Biophys. Acta pmid:12543379
Miettinen TA et al. Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. 2003 J. Lab. Clin. Med. pmid:12577049
Wiegand V et al. Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein. 2003 FASEB J. pmid:12594172
Nimmo MR and Cross NL Structural features of sterols required to inhibit human sperm capacitation. 2003 Biol. Reprod. pmid:12606419
Jaffé R et al. Organic compounds and trace metals of anthropogenic origin in sediments from Montego Bay, Jamaica: assessment of sources and distribution pathways. 2003 Environ. Pollut. pmid:12628208
Bortolomeazzi R et al. Presence of phytosterol oxides in crude vegetable oils and their fate during refining. 2003 J. Agric. Food Chem. pmid:12670187
Ottoson J and Stenström TA Faecal contamination of greywater and associated microbial risks. 2003 Water Res. pmid:12688699
Puglisi E et al. Cholesterol, beta-sitosterol, ergosterol, and coprostanol in agricultural soils. 2003 Mar-Apr J. Environ. Qual. pmid:12708669
Schief WR et al. Liquid-crystalline collapse of pulmonary surfactant monolayers. 2003 Biophys. J. pmid:12770885
Norlin M et al. On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. 2003 J. Lipid Res. pmid:12777473
Ward JN et al. Feeding of benthic foraminifera on diatoms and sewage-derived organic matter: an experimental application of lipid biomarker techniques. 2003 Mar. Environ. Res. pmid:12860436
Hellou J et al. Chemical contaminants and biological indicators of mussel health during gametogenesis. 2003 Environ. Toxicol. Chem. pmid:12959534
SIPERSTEIN MD et al. Prevention of plasma cholesterol elevation and atheromatosis in the cholesterol-fed bird by the administration of dihydrocholesterol. 1953 Circulation pmid:13019916
ROSENMAN RH et al. The effect of dihydrocholesterol on the absorption of cholesterol by the rat. 1954 Circ. Res. pmid:13116393
Tokimura Y et al. Electrophysiological studies in cerebrotendinous xanthomatosis. 1992 J. Neurol. Neurosurg. Psychiatr. pmid:1312580
BEHER WT and ANTHONY WL Prevention of the cholesterol type of fatty livers in mice by dietary dihydrocholesterol. 1954 J. Nutr. pmid:13163738
ROSENFELD RS et al. The transformation of cholesterol to coprostanol. 1954 J. Biol. Chem. pmid:13211667
IVY AC et al. Absorption of dihydrocholesterol and soya sterols by the rat's intestine. 1955 Am. J. Physiol. pmid:13268640
COLEMAN DL et al. Intestinal sterols. II. Determination of coprostanol and certain related sterols. 1956 Arch. Biochem. Biophys. pmid:13292920
SNOG-KJAER A et al. Conversion of cholesterol into coprosterol by bacteria in vitro. 1956 J. Gen. Microbiol. pmid:13319631
MOSBACH EH and BEVANS M Formation of gall stones in rabbits fed 3beta-cholestanol. 1956 Arch. Biochem. Biophys. pmid:13341064
GALLAGHER TF et al. The transformation of cholesterol-3d to coprostanol-d. Location of deuterium in coprostanol. 1956 J. Biol. Chem. pmid:13367005
WELLS WW Coprostanol formation. I. The effect of sodium taurocholate and Tween 80 on the sterol composition of rat feces. 1957 Arch. Biochem. Biophys. pmid:13395541
CHAIKOFF IL et al. Metabolism of cholestanol. I. Fate of cholestanol-4-C14 in the rat. II. Metabolic interrelations of cholestanol, epicholesterol, and delta4-cholestenone. 1957 J. Biol. Chem. pmid:13398433
BEHER WT et al. Effect of dihydrocholesterol and beta-sitosterol on cholesterol atherosclerosis in rabbits. 1957 Circ. Res. pmid:13414097
PRANGE I et al. Bacterial conversion of cholesterol into coprostanol independent of cerebrosides in the medium. 1958 Acta Pathol Microbiol Scand pmid:13508244
WELLS WW and COOPER SB Coprostanol formation. II. The opposing action of dietary lactose and calcium on cholesterol absorption. 1958 Arch. Biochem. Biophys. pmid:13534706
CHAPMAN DD and CHAIKOFF IL The manner of absorption of 3-beta-cholestanol and delta 4-cholestenone by the rat. 1959 J. Biol. Chem. pmid:13630893
GERSON T The determination of cholesterol and coprosterol in faecal lipids. 1960 Biochem. J. pmid:13704757
SETTY CS and IVY AC Intestinal absorption of coprostanol (coprosterol) in the rat. 1960 Am. J. Physiol. pmid:13750401
MOSBACH EH and BEVANS M Early pathologic and biochemical changes in rabbits fed dihydrocholesterol. 1960 Am. J. Pathol. pmid:13772987
WELLS WW et al. Lactose diets and cholesterol metabolism. I. Cholesterol absorption, coprostanol formation and bile acid excretion in the rat. 1960 J. Nutr. pmid:13784265
VAHOUNY GV et al. Comparison of lymphatic absorption of dihydrocholesterol and cholesterol in the rat. 1960 Arch. Biochem. Biophys. pmid:13840683
MOSBACH EH et al. A new method for the determination of dihydrocholesterol in tissues. 1963 Anal. Biochem. pmid:13936102
SMITH PF Fate of ergosterol and cholestanol in pleuro-pneumonia-like organisms. 1962 J. Bacteriol. pmid:13989541
Björkhem I et al. Mechanism and stereochemistry in the sequential enzymatic saturation of the two double bonds in cholesta-4,6-dien-3-one. 1992 J. Biol. Chem. pmid:1400303
CLAYTON RB and EDWARDS AM Conversion of 5-alpha-cholestan-3-beta-ol to delta-7-5-alpha-cholesten-3-beta-ol in cockroaches. 1963 J. Biol. Chem. pmid:14021649
AZARNOFF DL and TUCKER DR SEPARATION OF NUCLEAR SATURATED FROM UNSATURATED STEROLS. 1963 Biochim. Biophys. Acta pmid:14085943
SHEFER S et al. BIOSYNTHESIS OF 5-ALPHA-CHOLESTAN-3-BETA-OL IN THE RABBIT AND GUINEA PIG. 1964 J. Biol. Chem. pmid:14213342
HOFMANN AF and MOSBACH EH IDENTIFICATION OF ALLODEOXYCHOLIC ACID AS THE MAJOR COMPONENT OF GALLSTONES INDUCED IN THE RABBIT BY 5-ALPHA-CHOLESTAN-3-BETA-OL. 1964 J. Biol. Chem. pmid:14216431
ROSENFELD RS THE ISOLATION OF COPROSTANOL FROM STEROL ESTERS OF HUMAN FECES. 1964 Arch. Biochem. Biophys. pmid:14244675
KURODA M et al. A DERIVATIVE ISOTOPE DILUTION METHOD FOR DETERMINATION OF 5-ALPHA-CHOLESTAN-3-BETA-OL: ITS APPLICATION TO ADRENAL TISSUE. 1964 Anal. Biochem. pmid:14246124
SHEFER S et al. BIOSYNTHESIS OF 5-ALPHA-CHOLESTAN-3-BETA-OL IN RAT AND GUINEA PIG LIVER IN VITRO. 1965 J. Lipid Res. pmid:14280469
BELL RG et al. BILE ACIDS. XX. METABOLISM OF COPROSTANOL-4-14C IN THE RAT. 1965 J. Biol. Chem. pmid:14284701
TRUSWELL AS and MITCHELL WD SEPARATION OF CHOLESTEROL FROM ITS COMPANIONS, CHOLESTANOL AND DELTA-7-CHOLESTENOL, BY THIN-LAYER CHROMATOGRAPHY. 1965 J. Lipid Res. pmid:14336218