Coprosterol

Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.

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Introduction

To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coprosterol?

Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coprosterol

MeSH term MeSH ID Detail
Brain Diseases, Metabolic D001928 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Xanthomatosis D014973 17 associated lipids
Alcoholism D000437 27 associated lipids
Cataract D002386 34 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Coprosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coprosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coprosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coprosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Coprosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coprosterol?

Rodent Model

Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coprosterol

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Authors Title Published Journal PubMed Link
Yu L et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12444248
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Moghadasian MH et al. Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations. 2002 Arch. Neurol. pmid:11939886
Peng X et al. Spatial and temporal trend of sewage pollution indicated by coprostanol in Macao Estuary, southern China. 2002 Mar. Pollut. Bull. pmid:12398399
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Radhakrishnan A and McConnell HM Critical points in charged membranes containing cholesterol. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12368466
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von Bahr S et al. Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). 2002 Arterioscler. Thromb. Vasc. Biol. pmid:12117727
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Gagné F et al. Evidence of coprostanol estrogenicity to the freshwater mussel Elliptio complanata. 2001 Environ. Pollut. pmid:11586778
Eganhouse RP and Sherblom PM Anthropogenic organic contaminants in the effluent of a combined sewer overflow: impact on Boston Harbor. 2001 Mar. Environ. Res. pmid:11125703
Lin DS and Connor WE Fecal steroids of the coprolite of a Greenland Eskimo mummy, AD 1475: a clue to dietary sterol intake. 2001 Am. J. Clin. Nutr. pmid:11451716
Burnett JR et al. Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis. 2001 Clin. Chim. Acta pmid:11282095
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Yan JL et al. Microbial transformation of 3-hydroxy-5,6-cyclopropanocholestanes--an alternative route to 6-methylsteroids. 2000 Steroids pmid:11077084
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Collinder E et al. Influence of bacitracin on microbial functions in the gastrointestinal tract of horses. 2000 Equine Vet. J. pmid:10952385
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Björkhem I and Leitersdorf E Sterol 27-hydroxylase deficiency: a rare cause of xanthomas in normocholesterolemic humans. 2000 Trends Endocrinol. Metab. pmid:10856919
Radhakrishnan A et al. Condensed complexes, rafts, and the chemical activity of cholesterol in membranes. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:11050164
Collinder E et al. Six intestinal microflora-associated characteristics in sport horses. 2000 Equine Vet. J. pmid:10836477
Böttcher MF et al. Microflora-associated characteristics in faeces from allergic and nonallergic infants. 2000 Clin. Exp. Allergy pmid:11069568
Fernandes MB et al. Sedimentary 4-desmethyl sterols and n-alkanols in an eutrophic urban estuary, Capibaribe River, Brazil. 1999 Sci. Total Environ. pmid:10466230
Fadden K et al. Steroid metabolism along the gastrointestinal tract of the cannulated pig. 1999 Eur. J. Cancer Prev. pmid:10091041
Larking PW Cancer and low levels of plasma cholesterol: the relevance of cholesterol precursors and products to incidence of cancer. 1999 Prev Med pmid:10564630
Batta AK et al. Highly simplified method for gas-liquid chromatographic quantitation of bile acids and sterols in human stool. 1999 J. Lipid Res. pmid:10357847
Gylling H et al. Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. 1999 J. Lipid Res. pmid:10191283
Panda SK et al. Correlation of neomycin, faecal neutral and acid sterols with colon carcinogenesis in rats. 1999 Br. J. Cancer pmid:10376962
Radhakrishnan A and McConnell HM Condensed complexes of cholesterol and phospholipids. 1999 Biophys. J. pmid:10465761
Liendo A et al. Sterol composition and biosynthesis in Trypanosoma cruzi amastigotes. 1999 Mol. Biochem. Parasitol. pmid:10589983
Uchida K et al. Transformation of bile acids and sterols by clostridia (fusiform bacteria) in Wistar rats. 1999 Lipids pmid:10230721
Inoue K et al. Cholestanol induces apoptosis of cerebellar neuronal cells. 1999 Biochem. Biophys. Res. Commun. pmid:10066446
Gylling H et al. Oral guar gum treatment of intrahepatic cholestasis and pruritus in pregnant women: effects on serum cholestanol and other non-cholesterol sterols. 1998 Eur. J. Clin. Invest. pmid:9650008
Lin HS et al. Synthesis of 4 alpha-(2-propenyl)-5,6-secocholestan-3 alpha-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4 alpha-(2-propenyl)-5 alpha-cholestan-3 alpha-ol. 1998 Steroids pmid:9589554
Kawabata M et al. Pulmonary manifestations in cerebrotendinous xanthomatosis. 1998 Intern. Med. pmid:9868952
Vanhoof K and De Schrijver R The influence of enzyme-resistant starch on cholesterol metabolism in rats fed on a conventional diet. 1998 Br. J. Nutr. pmid:9828761
Srikumar TS et al. Analysis of fecal bile acids and neutral steroids using gas-liquid chromatography. 1998 Ann. Nutr. Metab. pmid:9745109
Miettinen TA et al. Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study. Finnish 4S Investigators. 1998 BMJ pmid:9552949
Wallis EJ et al. Cholestanol and survival with simvastatin. More data are needed. 1998 BMJ pmid:9794879
Reddy S et al. Faecal pH, bile acid and sterol concentrations in premenopausal Indian and white vegetarians compared with white omnivores. 1998 Br. J. Nutr. pmid:9771336