Coprosterol

Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.

Cross Reference

Introduction

To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coprosterol?

Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coprosterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Alcoholism D000437 27 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Biliary Fistula D001658 13 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Coprosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coprosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Coprosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coprosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Coprosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coprosterol?

Rodent Model

Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Coprosterol

Download all related citations
Per page 10 20 50 100 | Total 485
Authors Title Published Journal PubMed Link
White SW Cerebrotendinous xanthomatosis is treatable. 1985 Pediatr Dermatol pmid:3925446
Björkhem I et al. On the structural specificity in the regulation of the hydroxymethylglutaryl-CoA reductase and the cholesterol-7 alpha-hydroxylase in rats. Effects of cholestanol feeding. 1985 Biochim. Biophys. Acta pmid:3924107
Plank L et al. Effect of sterol incorporation on head group separation in liposomes. 1985 Chem. Phys. Lipids pmid:3924423
Skrede S et al. Biosynthesis of cholestanol from bile acid intermediates in the rabbit and the rat. 1985 J. Biol. Chem. pmid:3917436
Skrede S et al. A novel pathway for biosynthesis of cholestanol with 7 alpha-hydroxylated C27-steroids as intermediates, and its importance for the accumulation of cholestanol in cerebrotendinous xanthomatosis. 1985 J. Clin. Invest. pmid:3919058
Kasama T and Seyama Y Biochemical diagnosis of cerebrotendinous xanthomatosis using reversed phase thin layer chromatography. 1986 J. Biochem. pmid:3086296
Clifford AJ et al. Effects of dietary triglycerides on serum and liver lipids and sterol excretion of rats. 1986 J. Nutr. pmid:3088226
Miettinen TA et al. Cholesterol precursor sterols, plant sterols, and cholestanol in human bile and gallstones. 1986 Gastroenterology pmid:3081398
Hayashi E et al. Fecal bile acids and neutral sterols in rats with spontaneous colon cancer. 1986 Int. J. Cancer pmid:3082773
Seidel SB et al. Minor and trace sterols from marine invertebrates 56. Novel coprostanols from the marine sponge Petrosia ficiformis. 1986 Steroids pmid:3101232
Bhattacharyya AK Differences in uptake and esterification of saturated analogues of cholesterol by rat small intestine. 1986 Am. J. Physiol. pmid:3094380
Parker F Normocholesterolemic xanthomatosis. 1986 Arch Dermatol pmid:3096220
Midtvedt T et al. Influence of peroral antibiotics upon the biotransformatory activity of the intestinal microflora in healthy subjects. 1986 Eur. J. Clin. Invest. pmid:3084266
Garraffo HM and Gros EG Biosynthesis of bufadienolides in toads. VI. Experiments with [1,2-3H]cholesterol, [21-14C]coprostanol, and 5 beta-[21-14 C]pregnanolone in the toad Bufo arenarum. 1986 Sep-Oct Steroids pmid:3127947
Salen G et al. Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with cerebrotendinous xanthomatosis. Effect of chenodeoxycholic acid. 1987 N. Engl. J. Med. pmid:3106810
Lozano R et al. Metabolism of sterols of varying ring unsaturation and methylation by Caenorhabditis elegans. 1987 Lipids pmid:3104715
Peuchant E et al. Relationship between fecal neutral steroid concentrations and malignancy in colon cells. 1987 Cancer pmid:3111679
van Faassen A et al. Bile acids, neutral steroids, and bacteria in feces as affected by a mixed, a lacto-ovovegetarian, and a vegan diet. 1987 Am. J. Clin. Nutr. pmid:3120571
Midtvedt T et al. Establishment of a biochemically active intestinal ecosystem in ex-germfree rats. 1987 Appl. Environ. Microbiol. pmid:3124742
Vahouny GV et al. Dietary fiber supplementation and fecal bile acids, neutral steroids and divalent cations in rats. 1987 J. Nutr. pmid:2826726
Shefer S et al. Competitive inhibition of bile acid synthesis by endogenous cholestanol and sitosterol in sitosterolemia with xanthomatosis. Effect on cholesterol 7 alpha-hydroxylase. 1988 J. Clin. Invest. pmid:3143743
Hirsch D et al. DSC, X-ray and NMR properties of cholesterol-cholestanol-dihydrate crystals. 1988 Clin. Chim. Acta pmid:3133139
Koivisto PV and Miettinen TA Plasma and biliary cholestanol related to steroid metabolism in familial hypercholesterolemia patients with and without ileal exclusion. 1988 Clin. Chim. Acta pmid:3133140
Midtvedt AC et al. Development of five metabolic activities associated with the intestinal microflora of healthy infants. 1988 Jul-Aug J. Pediatr. Gastroenterol. Nutr. pmid:3135382
Andriamiarina R et al. Effects of stigmasterol-supplemented diets on fecal neutral sterols and bile acid excretion in rats. 1989 Ann. Nutr. Metab. pmid:2516429
Bhattacharyya AK et al. Differences in fecal excretion of cholesterol and bacterial degradation products in high- and low-responding rhesus monkeys: implications in colon cancer. 1989 Nutr Cancer pmid:2496397
Nicolaides N et al. Meibomian gland dysfunction. III. Meibomian gland lipids. 1989 Invest. Ophthalmol. Vis. Sci. pmid:2498228
Ha TB and Djerassi C Minor and trace sterols in marine invertebrates. 62. Novel coprostanols with unusual side chains from the marine sponge Calyx nicaeensis. 1989 Mar-May Steroids pmid:2508274
Wolthers BG et al. Reduction of urinary bile alcohol excretion and serum cholestanol in patients with cerebrotendinous xanthomatosis after oral administration of deoxycholic acid. 1990 Clin. Chim. Acta pmid:2282689
Strandberg TE et al. Metabolic variables of cholesterol during squalene feeding in humans: comparison with cholestyramine treatment. 1990 J. Lipid Res. pmid:2246614
Midtvedt T et al. Intestinal microbial conversion of cholesterol to coprostanol in man. Influence of antibiotics. 1990 APMIS pmid:2223037
McKenna P et al. A case of cerebrotendinous xanthomatosis. II: The sterol content of a cataractous lens. 1990 Br J Ophthalmol pmid:2285688
Bencze KS et al. Magnetic resonance imaging of the brain and spinal cord in cerebrotendinous xanthomatosis. 1990 J. Neurol. Neurosurg. Psychiatr. pmid:2107278
Overturf ML et al. Dietary cholesterol absorption, and sterol and bile acid excretion in hypercholesterolemia-resistant white rabbits. 1990 J. Lipid Res. pmid:2086701
Kim KS et al. Effects of cholestanol feeding on corneal dystrophy in mice. 1991 Biochim. Biophys. Acta pmid:1911869
Dotti MT et al. Cerebrotendinous xanthomatosis as a multisystem disease mimicking premature ageing. 1991 Dev. Neurosci. pmid:1817044
Sziegoleit A and Linder D Studies on the sterol-binding capacity of human pancreatic elastase 1. 1991 Gastroenterology pmid:1993499
Kosaka D et al. Stable isotope dilution assay for 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol and 5 beta-cholestane-3 alpha,7 alpha,12 alpha,23,25-pentol in human serum using [26,27-D6] labeled internal standards; a highly accurate approach to the serological diagnosis of cerebrotendinous xanthomatosis. 1991 Clin. Chim. Acta pmid:1934504
Kuriyama M et al. High levels of plant sterols and cholesterol precursors in cerebrotendinous xanthomatosis. 1991 J. Lipid Res. pmid:2066659
Nakamura T et al. Combined treatment with chenodeoxycholic acid and pravastatin improves plasma cholestanol levels associated with marked regression of tendon xanthomas in cerebrotendinous xanthomatosis. 1991 Metab. Clin. Exp. pmid:1908036
Nikkilä K et al. High cholestanol and low campesterol-to-sitosterol ratio in serum of patients with primary biliary cirrhosis before liver transplantation. 1991 Hepatology pmid:2010161
Salen G et al. Biochemical abnormalities in cerebrotendinous xanthomatosis. 1991 Dev. Neurosci. pmid:1817043
Fujiyama J et al. Parkinsonism in cerebrotendinous xanthomatosis. 1991 Mar-Apr Jpn. J. Med. pmid:1865593
Nikkilä K et al. Serum and hepatic cholestanol, squalene and noncholesterol sterols in man: a study on liver transplantation. 1992 Hepatology pmid:1568728
Owen RW et al. Faecal steroids and colorectal cancer: steroid profiles in subjects with adenomatous polyps of the large bowel. 1992 Eur. J. Cancer Prev. pmid:1463972
Björkhem I et al. Mechanism and stereochemistry in the sequential enzymatic saturation of the two double bonds in cholesta-4,6-dien-3-one. 1992 J. Biol. Chem. pmid:1400303
Lee SP et al. Biliary sludge as a cause of acute pancreatitis. 1992 N. Engl. J. Med. pmid:1734248
Steinberg WM Acute pancreatitis--never leave a stone unturned. 1992 N. Engl. J. Med. pmid:1734255
Nikkilä K et al. Liver transplantation modifies serum cholestanol, cholesterol precursor and plant sterol levels. 1992 Clin. Chim. Acta pmid:1499139
Tokimura Y et al. Electrophysiological studies in cerebrotendinous xanthomatosis. 1992 J. Neurol. Neurosurg. Psychiatr. pmid:1312580