Coprosterol

Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.

Cross Reference

Introduction

To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coprosterol?

Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coprosterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Alcoholism D000437 27 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Biliary Fistula D001658 13 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Coprosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coprosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coprosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coprosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Coprosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coprosterol?

Rodent Model

Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coprosterol

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Authors Title Published Journal PubMed Link
van Himbergen TM et al. Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19834104
Gylling H and Miettinen TA Baseline intestinal absorption and synthesis of cholesterol regulate its response to hypolipidaemic treatments in coronary patients. 2002 Atherosclerosis pmid:11849674
Miettinen TA and Gylling H Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. 2002 Atherosclerosis pmid:12119203
Wang X et al. Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters. 2015 Atherosclerosis pmid:26184696
Sittiwet C et al. Cholesterol metabolism and non-cholesterol sterol distribution in lipoproteins of type 1 diabetes: the effect of improved glycemic control. 2007 Atherosclerosis pmid:16996519
Vanhanen HT and Miettinen TA Cholesterol absorption and synthesis during pravastatin, gemfibrozil and their combination. 1995 Atherosclerosis pmid:7661873
Hoenig MR et al. Cholestanol: a serum marker to guide LDL cholesterol-lowering therapy. 2006 Atherosclerosis pmid:16216250
Miettinen TA et al. Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: the Cardiovascular Risk in Young Finns Study. 2010 Atherosclerosis pmid:19963215
Niesor EJ et al. Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects. 2011 Atherosclerosis pmid:21982411
Takashima K et al. The hypocholesterolemic action of TA-7552 and its effects on cholesterol metabolism in the rat. 1994 Atherosclerosis pmid:7980699
Miettinen TA et al. Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: the cardiovascular risk in Young Finns Study. 2008 Atherosclerosis pmid:18178213
Björkhem I and Hansson M Cerebrotendinous xanthomatosis: an inborn error in bile acid synthesis with defined mutations but still a challenge. 2010 Biochem. Biophys. Res. Commun. pmid:20494109
Rodriguez RJ et al. A requirement for ergosterol to permit growth of yeast sterol auxotrophs on cholestanol. 1982 Biochem. Biophys. Res. Commun. pmid:6809003
Inoue K et al. Cholestanol induces apoptosis of cerebellar neuronal cells. 1999 Biochem. Biophys. Res. Commun. pmid:10066446
GERSON T The determination of cholesterol and coprosterol in faecal lipids. 1960 Biochem. J. pmid:13704757
Smith AG et al. The intermediacy of 3-oxo steroids in the conversion of cholest-5-en-3 -ol into 5 -cholestan-3 -ol by the starfish Asterias rubens and Porania pulvillus. 1972 Biochem. J. pmid:4566194
Contreras LM et al. Altered lipid composition and enzyme activities of plasma membranes from Trypanosoma (Schizotrypanum) cruzi epimastigotes grown in the presence of sterol biosynthesis inhibitors. 1997 Biochem. Pharmacol. pmid:9113089
Björkhem I et al. Isolation of 5 alpha-cholestane-3 beta, 7 alpha-diol from bile of patients with cerebrotendinous xanthomatosis. Inefficiency of this steroid as a precursor to cholestanol. 1983 Biochim. Biophys. Acta pmid:6412759
Hagen JP and McConnell HM Critical pressures in multicomponent lipid monolayers. 1996 Biochim. Biophys. Acta pmid:8639690
Addona GH et al. Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site. 2003 Biochim. Biophys. Acta pmid:12543379