Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rosenfeld RS | Analysis of sterol extracts for cholestanol. | 1965 | Anal. Biochem. | pmid:5323673 |
| Schubert K and Kaufmann G | [Formation of sterol esters in bacterial cells]. | 1965 | Biochim. Biophys. Acta | pmid:5326537 |
| Lüscher IF et al. | The introduction of one or two 3 beta-cholestanyl residues into benzylpenicilloyl-eicosa-L-lysines greatly potentiates their tolerogenicity for anti-benzylpenicillol IgE antibody formation. | 1984 | Eur. J. Immunol. | pmid:6229410 |
| Ullrich IH et al. | Alterations of fecal steroid composition induced by changes in dietary fiber consumption. | 1981 | Am. J. Clin. Nutr. | pmid:6270998 |
| Sekimoto H et al. | Interrelationship between serum and fecal sterols. | 1983 | Jpn. J. Med. | pmid:6302358 |
| Andersson S et al. | 25-hydroxylation of C27-steroids and vitamin D3 by a constitutive cytochrome P-450 from rat liver microsomes. | 1983 | J. Biol. Chem. | pmid:6304056 |
| Watabe T et al. | Mouse liver microsomal cholesterol epoxide hydrolase: a specific inhibition of its activity by 5,6 alpha-Imino-5 alpha-cholestan-3 alpha-OL. | 1983 Apr-May | Chem. Biol. Interact. | pmid:6406079 |
| Kaibara N et al. | Fecal bile acids and neutral sterols in Japanese with large bowel carcinoma. | 1983 | Oncology | pmid:6408548 |
| Canelas HM et al. | Cerebrotendinous xanthomatosis: clinical and laboratory study of 2 cases. | 1983 | Acta Neurol. Scand. | pmid:6410671 |
| Björkhem I et al. | Isolation of 5 alpha-cholestane-3 beta, 7 alpha-diol from bile of patients with cerebrotendinous xanthomatosis. Inefficiency of this steroid as a precursor to cholestanol. | 1983 | Biochim. Biophys. Acta | pmid:6412759 |