Coprosterol

Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.

Cross Reference

Introduction

To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coprosterol?

Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coprosterol

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Alcoholism D000437 27 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Biliary Fistula D001658 13 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Coprosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coprosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coprosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coprosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Coprosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coprosterol?

Rodent Model

Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coprosterol

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Authors Title Published Journal PubMed Link
Takiguchi H et al. Suppression of cholesterol synthesis in rat liver by dihydrocholesterol administration. 1966 J. Biochem. pmid:4860849
Einarsson K et al. Influence of deoxycholic acid feeding on the elimination of cholesterol in normolipaemic subjects. 1974 Clin Sci Mol Med pmid:4611679
Kellogg TF On the site of the microbiological reduction of cholesterol to coprostanol in the rat. 1973 Lipids pmid:4584737
Horton BJ et al. Abnormal cholesterol uptake, storage, and synthesis in the livers of 2-acetylaminofluorene-fed rats. 1973 Cancer Res. pmid:4578071
Noll BW et al. Bile acids. XXXVII. Identification of the 3 beta isomers of allocholic and allochenodeoxycholic acids as metabolites of 5 -cholestanol in the rat. 1973 J. Lipid Res. pmid:4572742
Smith AG et al. The intermediacy of 3-oxo steroids in the conversion of cholest-5-en-3 -ol into 5 -cholestan-3 -ol by the starfish Asterias rubens and Porania pulvillus. 1972 Biochem. J. pmid:4566194
Norman AW et al. Studies on the biological properties of polyene antibiotics: comparison of other polyenes with filipin in their ability to interact specifically with sterol. 1972 Biochim. Biophys. Acta pmid:4565643
Eyssen H et al. Role of the cecum in maintaing 5 -steroid- and fatty acid-reducing activity of the rat intestinal microflora. 1972 J. Nutr. pmid:4563003
Ghosh D and Tinoco J Monolayer interactions of individual lecithins with natural sterols. 1972 Biochim. Biophys. Acta pmid:4557356
Salen G and Polito A Biosynthesis of 5 -cholestan-3 -ol in cerebrotendinous xanthomatosis. 1972 J. Clin. Invest. pmid:4550120
Endo T et al. Bile acid metabolism in benign recurrent intrahepatic cholestasis. Comparative studies on the icteric and anicteric phases of a single case. 1979 Gastroenterology pmid:437403
Salen G and Grundy SM The metabolism of cholestanol, cholesterol, and bile acids in cerebrotendinous xanthomatosis. 1973 J. Clin. Invest. pmid:4355999
White SW Cerebrotendinous xanthomatosis is treatable. 1985 Pediatr Dermatol pmid:3925446
Plank L et al. Effect of sterol incorporation on head group separation in liposomes. 1985 Chem. Phys. Lipids pmid:3924423
Björkhem I et al. On the structural specificity in the regulation of the hydroxymethylglutaryl-CoA reductase and the cholesterol-7 alpha-hydroxylase in rats. Effects of cholestanol feeding. 1985 Biochim. Biophys. Acta pmid:3924107
Skrede S et al. A novel pathway for biosynthesis of cholestanol with 7 alpha-hydroxylated C27-steroids as intermediates, and its importance for the accumulation of cholestanol in cerebrotendinous xanthomatosis. 1985 J. Clin. Invest. pmid:3919058
Skrede S et al. Biosynthesis of cholestanol from bile acid intermediates in the rabbit and the rat. 1985 J. Biol. Chem. pmid:3917436
Smith LB et al. The effect of dietary corn oil and cholesterol level on the neutral steroid composition in the large intestinal contents of the rat. 1979 J. Nutr. pmid:385812
Lee SP and Scott AJ Dihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury. 1979 Br J Exp Pathol pmid:383127
Gallo-Torres HE et al. Some effects of deoxycholate administration on the metabolism of cholesterol in man. 1979 Am. J. Clin. Nutr. pmid:377936