Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sadzikowski MR et al. | Cholesterol-reducing bacterium from human feces. | 1977 | Appl. Environ. Microbiol. | pmid:335969 |
| Sulpice JC et al. | Diet and sterol biohydrogenation in the rat: occurrence of epicoprostanol. | 1978 | Lipids | pmid:345032 |
| Huang CT et al. | Fecal steroids in diarrhea. II. Travellers' diarrhea. | 1978 | Am. J. Clin. Nutr. | pmid:345794 |
| Lee SP | Enhanced fluid transport across gallbladder mucosa in experimental cholelithiasis. | 1978 | Am. J. Physiol. | pmid:352156 |
| Férézou J et al. | Daily elimination of fecal neutral sterols by humans. | 1978 | Digestion | pmid:367852 |
| Gallo-Torres HE et al. | Some effects of deoxycholate administration on the metabolism of cholesterol in man. | 1979 | Am. J. Clin. Nutr. | pmid:377936 |
| Lee SP and Scott AJ | Dihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury. | 1979 | Br J Exp Pathol | pmid:383127 |
| Smith LB et al. | The effect of dietary corn oil and cholesterol level on the neutral steroid composition in the large intestinal contents of the rat. | 1979 | J. Nutr. | pmid:385812 |
| Skrede S et al. | Biosynthesis of cholestanol from bile acid intermediates in the rabbit and the rat. | 1985 | J. Biol. Chem. | pmid:3917436 |
| Skrede S et al. | A novel pathway for biosynthesis of cholestanol with 7 alpha-hydroxylated C27-steroids as intermediates, and its importance for the accumulation of cholestanol in cerebrotendinous xanthomatosis. | 1985 | J. Clin. Invest. | pmid:3919058 |