Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Kaczocha M et al. | Anandamide externally added to lipid vesicles containing trapped fatty acid amide hydrolase (FAAH) is readily hydrolyzed in a sterol-modulated fashion. | 2012 | ACS Chem Neurosci | pmid:22860204 |
| Burcelin R et al. | Gut microbiota and diabetes: from pathogenesis to therapeutic perspective. | 2011 | Acta Diabetol | pmid:21964884 |
| Canelas HM et al. | Cerebrotendinous xanthomatosis: clinical and laboratory study of 2 cases. | 1983 | Acta Neurol. Scand. | pmid:6410671 |
| van Heijst AF et al. | Chronic diarrhoea as a dominating symptom in two children with cerebrotendinous xanthomatosis. | 1996 | Acta Paediatr. | pmid:8863874 |
| PRANGE I et al. | Bacterial conversion of cholesterol into coprostanol independent of cerebrosides in the medium. | 1958 | Acta Pathol Microbiol Scand | pmid:13508244 |
| Gustafsson BE and Norin KE | Development of germfree animal characteristics in conventional rats in antibiotics. | 1977 | Acta Pathol Microbiol Scand B | pmid:320818 |
| Gallo-Torres HE et al. | Some effects of deoxycholate administration on the metabolism of cholesterol in man. | 1979 | Am. J. Clin. Nutr. | pmid:377936 |
| Mutanen A et al. | Serum plant sterols, cholestanol, and cholesterol precursors associate with histological liver injury in pediatric onset intestinal failure. | 2014 | Am. J. Clin. Nutr. | pmid:25099547 |
| Ullrich IH et al. | Alterations of fecal steroid composition induced by changes in dietary fiber consumption. | 1981 | Am. J. Clin. Nutr. | pmid:6270998 |