Coprosterol

Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.

Cross Reference

Introduction

To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coprosterol?

Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coprosterol

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Alcoholism D000437 27 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Coprosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coprosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coprosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coprosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Coprosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coprosterol?

Rodent Model

Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coprosterol

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Authors Title Published Journal PubMed Link
Cabral AC et al. An integrated evaluation of some faecal indicator bacteria (FIB) and chemical markers as potential tools for monitoring sewage contamination in subtropical estuaries. 2018 Environ. Pollut. pmid:29339343
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Mast N et al. Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum. 2017 J. Biol. Chem. pmid:28190002
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Frena M et al. Evaluation of anthropogenic contamination using sterol markers in a tropical estuarine system of northeast Brazil. 2016 Mar. Pollut. Bull. pmid:27207024
Matić Bujagić I et al. Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia. 2016 Environ. Pollut. pmid:26874877
Rada JPA et al. Sewage contamination of sediments from two Portuguese Atlantic coastal systems, revealed by fecal sterols. 2016 Mar. Pollut. Bull. pmid:26778497
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Antharam VC et al. An Integrated Metabolomic and Microbiome Analysis Identified Specific Gut Microbiota Associated with Fecal Cholesterol and Coprostanol in Clostridium difficile Infection. 2016 PLoS ONE pmid:26871580
Whiteside W et al. Altered Cholesterol Metabolism and Hypocholesterolemia in Patients with Single Ventricle following Fontan Palliation. 2016 J. Pediatr. pmid:26806364
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Aoki K et al. Anagliptin decreases serum lathosterol level in patients with type 2 diabetes: a pilot study. 2015 Expert Opin Pharmacother pmid:26098722
Moraes EA et al. Cholestanol-loaded-cyclodextrin improves the quality of stallion spermatozoa after cryopreservation. 2015 Anim. Reprod. Sci. pmid:26005214
Luister A et al. Increased plant sterol deposition in vascular tissue characterizes patients with severe aortic stenosis and concomitant coronary artery disease. 2015 Steroids pmid:25814070
Benesch MG et al. A DSC and FTIR spectroscopic study of the effects of the epimeric coprostan-3-ols and coprostan-3-one on the thermotropic phase behaviour and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogues. 2015 Chem. Phys. Lipids pmid:25804450
Kozanecka W et al. Synthesis, spectroscopy, theoretical and biological studies of new gramine-steroids salts and conjugates. 2015 Steroids pmid:25777948
Benesch MG et al. A DSC and FTIR spectroscopic study of the effects of the epimeric cholestan-3-ols and cholestan-3-one on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes: Comparison with their 5-cholesten analogs. 2015 Chem. Phys. Lipids pmid:25732198
Saeed T et al. Spatial assessment of the sewage contamination of Kuwait's marine areas. 2015 Mar. Pollut. Bull. pmid:25691339
Doukyu N and Nihei S Cholesterol oxidase with high catalytic activity from Pseudomonas aeruginosa: Screening, molecular genetic analysis, expression and characterization. 2015 J. Biosci. Bioeng. pmid:25573142
Carreira RS et al. Evidence of sewage input to inner shelf sediments in the NE coast of Brazil obtained by molecular markers distribution. 2015 Mar. Pollut. Bull. pmid:25467184
Bach D et al. Modulation of the kinetics of 3β-hydroxy-5-oxo-5,6-secocholestan-6-al/phosphatidylethanolamine Schiff base formation by cholesterol and cholesterol crystallization. 2015 Chem. Phys. Lipids pmid:25582951
Appadurai V et al. Apparent underdiagnosis of Cerebrotendinous Xanthomatosis revealed by analysis of ~60,000 human exomes. 2015 Mol. Genet. Metab. pmid:26643207
Lyons BP et al. Microbial water quality and sedimentary faecal sterols as markers of sewage contamination in Kuwait. 2015 Mar. Pollut. Bull. pmid:26228071
Matsuoka K et al. Competitive Solubilization of Cholesterol/Cholesteryl Oleate and Seven Species of Sterol/Stanol in Model Intestinal Solution System. 2015 J Oleo Sci pmid:26136176
Silbernagel G et al. Intestinal cholesterol absorption, treatment with atorvastatin, and cardiovascular risk in hemodialysis patients. 2015 J. Am. Coll. Cardiol. pmid:26022817
Lin X et al. Plasma biomarker of dietary phytosterol intake. 2015 PLoS ONE pmid:25668184
Mutanen A et al. Serum plant sterols, cholestanol, and cholesterol precursors associate with histological liver injury in pediatric onset intestinal failure. 2014 Am. J. Clin. Nutr. pmid:25099547
Harrault L et al. Are fecal stanols suitable to record and identify a pulse of human fecal contamination in short-term exposed shellfish? A microcosm study. 2014 Mar. Pollut. Bull. pmid:25455370
Tolosa I et al. Steroid markers to assess sewage and other sources of organic contaminants in surface sediments of Cienfuegos Bay, Cuba. 2014 Mar. Pollut. Bull. pmid:25127498
Mignarri A et al. A suspicion index for early diagnosis and treatment of cerebrotendinous xanthomatosis. 2014 J. Inherit. Metab. Dis. pmid:24442603
Varga VE et al. [Laboratory diagnosis of a rare congenital neurodegenerative disease: cerebrotendinous xanthomatosis]. 2014 Orv Hetil pmid:24836315
Yoshinaga T et al. Clinical and radiological findings of a cerebrotendinous xanthomatosis patient with a novel p.A335V mutation in the CYP27A1 gene. 2014 Intern. Med. pmid:25447658
Sistiaga A et al. The Neanderthal meal: a new perspective using faecal biomarkers. 2014 PLoS ONE pmid:24963925
Martins CC et al. An integrated evaluation of molecular marker indices and linear alkylbenzenes (LABs) to measure sewage input in a subtropical estuary (Babitonga Bay, Brazil). 2014 Environ. Pollut. pmid:24556228
Hallikainen M et al. Cholesterol metabolism and serum non-cholesterol sterols: summary of 13 plant stanol ester interventions. 2014 Lipids Health Dis pmid:24766766
Imperatore C et al. Phallusiasterols A and B: two new sulfated sterols from the Mediterranean tunicate Phallusia fumigata and their effects as modulators of the PXR receptor. 2014 Mar Drugs pmid:24705503
Mandrile G et al. Cerebrotendinous xanthomatosis: recurrence of the CYP27A1 mutation p.Arg479Cys in Sardinia. 2014 Neurol. Sci. pmid:24584636
von der Lühe B et al. Investigation of sterols as potential biomarkers for the detection of pig (S. s. domesticus) decomposition fluid in soils. 2013 Forensic Sci. Int. pmid:23583120
Björkhem I Cerebrotendinous xanthomatosis. 2013 Curr. Opin. Lipidol. pmid:23759795
Martini G et al. Long-term bone density evaluation in cerebrotendinous xanthomatosis: evidence of improvement after chenodeoxycholic acid treatment. 2013 Calcif. Tissue Int. pmid:23212544