Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| MOSBACH EH and BEVANS M | Formation of gall stones in rabbits fed 3beta-cholestanol. | 1956 | Arch. Biochem. Biophys. | pmid:13341064 |
| BEHER WT et al. | Effect of dihydrocholesterol and beta-sitosterol on cholesterol atherosclerosis in rabbits. | 1957 | Circ. Res. | pmid:13414097 |
| WELLS WW | Coprostanol formation. I. The effect of sodium taurocholate and Tween 80 on the sterol composition of rat feces. | 1957 | Arch. Biochem. Biophys. | pmid:13395541 |
| CHAIKOFF IL et al. | Metabolism of cholestanol. I. Fate of cholestanol-4-C14 in the rat. II. Metabolic interrelations of cholestanol, epicholesterol, and delta4-cholestenone. | 1957 | J. Biol. Chem. | pmid:13398433 |
| WELLS WW and COOPER SB | Coprostanol formation. II. The opposing action of dietary lactose and calcium on cholesterol absorption. | 1958 | Arch. Biochem. Biophys. | pmid:13534706 |
| PRANGE I et al. | Bacterial conversion of cholesterol into coprostanol independent of cerebrosides in the medium. | 1958 | Acta Pathol Microbiol Scand | pmid:13508244 |
| CHAPMAN DD and CHAIKOFF IL | The manner of absorption of 3-beta-cholestanol and delta 4-cholestenone by the rat. | 1959 | J. Biol. Chem. | pmid:13630893 |
| MOSBACH EH and BEVANS M | Early pathologic and biochemical changes in rabbits fed dihydrocholesterol. | 1960 | Am. J. Pathol. | pmid:13772987 |
| GERSON T | The determination of cholesterol and coprosterol in faecal lipids. | 1960 | Biochem. J. | pmid:13704757 |
| VAHOUNY GV et al. | Comparison of lymphatic absorption of dihydrocholesterol and cholesterol in the rat. | 1960 | Arch. Biochem. Biophys. | pmid:13840683 |