Coprosterol

Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.

Cross Reference

Introduction

To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coprosterol?

Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coprosterol

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Alcoholism D000437 27 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Coprosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coprosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Coprosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coprosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Coprosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coprosterol?

Rodent Model

Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Coprosterol

Download all related citations
Per page 10 20 50 100 | Total 485
Authors Title Published Journal PubMed Link
Dantas-Leite L et al. Antiproliferative synergism of azasterols and antifolates against Toxoplasma gondii. 2005 Int. J. Antimicrob. Agents pmid:15664482
Nikkilä K et al. Sterol parameters as markers of liver function in primary biliary cirrhosis before and after liver transplantation. 2005 Transpl. Int. pmid:15691276
Miettinen TA et al. Plant sterols in serum and in atherosclerotic plaques of patients undergoing carotid endarterectomy. 2005 J. Am. Coll. Cardiol. pmid:15936608
Clarenbach JJ et al. Isotopomer spectral analysis of intermediates of cholesterol synthesis in patients with cerebrotendinous xanthomatosis. 2005 Metab. Clin. Exp. pmid:15736111
Clemen CS et al. Cerebrotendinous xanthomatosis: a treatable ataxia. 2005 Neurology pmid:15851751
Corradini SG et al. Comparison of changes in lipid profile after bilio-intestinal bypass and gastric banding in patients with morbid obesity. 2005 Obes Surg pmid:15826472
Veiga P et al. Correlation between faecal microbial community structure and cholesterol-to-coprostanol conversion in the human gut. 2005 FEMS Microbiol. Lett. pmid:15621423
Lindenthal B et al. Serum lipid analysis confirms the diagnosis of X-linked dominant chondrodysplasia punctata - Conradi-Hünermann-Happle syndrome. 2004 Mar-Apr Klin Padiatr pmid:15106076
Bartholdi D et al. Spinal phenotype of cerebrotendinous xanthomatosis--a pitfall in the diagnosis of multiple sclerosis. 2004 J. Neurol. pmid:14999499
Hughes KA and Thompson A Distribution of sewage pollution around a maritime Antarctic research station indicated by faecal coliforms, Clostridium perfringens and faecal sterol markers. 2004 Environ. Pollut. pmid:14638291
Dongowski G and Lorenz A Intestinal steroids in rats are influenced by the structural parameters of pectin. 2004 J. Nutr. Biochem. pmid:15068812
Okonogi TM and McConnell HM Contrast inversion in the epifluorescence of cholesterol-phospholipid monolayers. 2004 Biophys. J. pmid:14747323
Gérard P et al. Gnotobiotic rats harboring human intestinal microbiota as a model for studying cholesterol-to-coprostanol conversion. 2004 FEMS Microbiol. Ecol. pmid:19712322
Moghadasian MH Cerebrotendinous xanthomatosis: clinical course, genotypes and metabolic backgrounds. 2004 Clin Invest Med pmid:15061585
Rontani JF and Aubert C Electron ionization mass spectral fragmentation of derivatized 4,5- and 5,6-epoxysterols. 2004 Rapid Commun. Mass Spectrom. pmid:15116422
Dotti MT et al. Normalisation of serum cholestanol concentration in a patient with cerebrotendinous xanthomatosis by combined treatment with chenodeoxycholic acid, simvastatin and LDL apheresis. 2004 Neurol. Sci. pmid:15549503
Isobe KO et al. Effect of environmental factors on the relationship between concentrations of coprostanol and fecal indicator bacteria in tropical (Mekong Delta) and temperate (Tokyo) freshwaters. 2004 Appl. Environ. Microbiol. pmid:14766559
Dantas-Leite L et al. Selective anti-Toxoplasma gondii activities of azasterols. 2004 Int. J. Antimicrob. Agents pmid:15194134
Ohgami N et al. Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15314240
Keller S and Jahreis G Determination of underivatised sterols and bile acid trimethyl silyl ether methyl esters by gas chromatography-mass spectrometry-single ion monitoring in faeces. 2004 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:15556534
Keller RK et al. Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome. 2004 J. Lipid Res. pmid:14594996
Berger A et al. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. 2004 Lipids Health Dis pmid:14969592
Sperhake JP and Matschke J [Cerebrotendinous xanthomatosis--a treatable metabolic disorder]. 2004 Nervenarzt pmid:15257383
Puglisi E et al. Cholesterol, beta-sitosterol, ergosterol, and coprostanol in agricultural soils. 2003 Mar-Apr J. Environ. Qual. pmid:12708669
Dongowski G et al. Steroids in the intestinal tract of rats are affected by dietary-fibre-rich barley-based diets. 2003 Br. J. Nutr. pmid:14667183
Schief WR et al. Liquid-crystalline collapse of pulmonary surfactant monolayers. 2003 Biophys. J. pmid:12770885
Hellou J et al. Chemical contaminants and biological indicators of mussel health during gametogenesis. 2003 Environ. Toxicol. Chem. pmid:12959534
Nimmo MR and Cross NL Structural features of sterols required to inhibit human sperm capacitation. 2003 Biol. Reprod. pmid:12606419
Bortolomeazzi R et al. Presence of phytosterol oxides in crude vegetable oils and their fate during refining. 2003 J. Agric. Food Chem. pmid:12670187
Norlin M et al. On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. 2003 J. Lipid Res. pmid:12777473
Wiegand V et al. Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein. 2003 FASEB J. pmid:12594172
Cao H et al. Unraveling the mystery surrounding cholesterol's condensing effect. 2003 J. Am. Chem. Soc. pmid:14692747
Ward JN et al. Feeding of benthic foraminifera on diatoms and sewage-derived organic matter: an experimental application of lipid biomarker techniques. 2003 Mar. Environ. Res. pmid:12860436
Ottoson J and Stenström TA Faecal contamination of greywater and associated microbial risks. 2003 Water Res. pmid:12688699
Jaffé R et al. Organic compounds and trace metals of anthropogenic origin in sediments from Montego Bay, Jamaica: assessment of sources and distribution pathways. 2003 Environ. Pollut. pmid:12628208
Antonio González Oreja J and Ignacio Saiz Salinas J Recovery simulations of grossly polluted sediments in the Bilbao Estuary. 2003 Mar. Pollut. Bull. pmid:12535968
Ito S et al. Combined treatment with LDL-apheresis, chenodeoxycholic acid and HMG-CoA reductase inhibitor for cerebrotendinous xanthomatosis. 2003 J. Neurol. Sci. pmid:14607320
Collinder E et al. Influence of zinc bacitracin and Bacillus licheniformis on microbial intestinal functions in weaned piglets. 2003 Vet. Res. Commun. pmid:14609263
Addona GH et al. Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site. 2003 Biochim. Biophys. Acta pmid:12543379
Seyama Y Cholestanol metabolism, molecular pathology, and nutritional implications. 2003 J Med Food pmid:14585188
Miettinen TA et al. Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. 2003 J. Lab. Clin. Med. pmid:12577049
Yu L et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12444248
Rodrigues JC et al. Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis. 2002 Antimicrob. Agents Chemother. pmid:11796362
Petucci C et al. Differentiation of stereoisomeric steroids by reactions with phosphenium ions. 2002 J. Am. Soc. Mass Spectrom. pmid:11951974
Bull ID et al. The origin of faeces by means of biomarker detection. 2002 Environ Int pmid:11934114
Moghadasian MH et al. Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations. 2002 Arch. Neurol. pmid:11939886
Peng X et al. Spatial and temporal trend of sewage pollution indicated by coprostanol in Macao Estuary, southern China. 2002 Mar. Pollut. Bull. pmid:12398399
Okonogi TM et al. Two fatty acids can replace one phospholipid in condensed complexes with cholesterol. 2002 Biochim. Biophys. Acta pmid:12100988
Gylling H and Miettinen TA Baseline intestinal absorption and synthesis of cholesterol regulate its response to hypolipidaemic treatments in coronary patients. 2002 Atherosclerosis pmid:11849674
Miettinen TA and Gylling H Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. 2002 Atherosclerosis pmid:12119203
Simonen PP et al. Body weight modulates cholesterol metabolism in non-insulin dependent type 2 diabetics. 2002 Obes. Res. pmid:12006631
Radhakrishnan A and McConnell HM Critical points in charged membranes containing cholesterol. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12368466
Veatch SL and Keller SL Organization in lipid membranes containing cholesterol. 2002 Phys. Rev. Lett. pmid:12484857
Brämswig S et al. Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:11788421
Nakajima N et al. Biosynthesis of cholestanol in higher plants. 2002 Phytochemistry pmid:12031446
Gagné F et al. Biomarker study of a municipal effluent dispersion plume in two species of freshwater mussels. 2002 Environ. Toxicol. pmid:12112623
Heller R et al. [Cerebrotendinous xanthomatosis, a treatable metabolic disorder]. 2002 Nervenarzt pmid:12486565
Collinder E et al. Biochemical intestinal parameters in pigs reared outdoors and indoors, and in germ-free pigs. 2002 J Vet Med A Physiol Pathol Clin Med pmid:12069263
Cruz JC et al. Synthesis and biochemical properties of a new photoactivatable cholesterol analog 7,7-azocholestanol and its linoleate ester in Chinese hamster ovary cell lines. 2002 J. Lipid Res. pmid:12177179
Schönning C et al. Faecal contamination of source-separated human urine based on the content of faecal sterols. 2002 Water Res. pmid:12092571
Lamon-Fava S et al. Two novel mutations in the sterol 27-hydroxylase gene causing cerebrotendinous xanthomatosis. 2002 Clin. Genet. pmid:12000359
von Bahr S et al. Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). 2002 Arterioscler. Thromb. Vasc. Biol. pmid:12117727
Mondelli M et al. Cerebrotendinous xanthomatosis: 11-year treatment with chenodeoxycholic acid in five patients. An electrophysiological study. 2001 J. Neurol. Sci. pmid:11574103
Gagné F et al. Evidence of coprostanol estrogenicity to the freshwater mussel Elliptio complanata. 2001 Environ. Pollut. pmid:11586778
Eganhouse RP and Sherblom PM Anthropogenic organic contaminants in the effluent of a combined sewer overflow: impact on Boston Harbor. 2001 Mar. Environ. Res. pmid:11125703
Lin DS and Connor WE Fecal steroids of the coprolite of a Greenland Eskimo mummy, AD 1475: a clue to dietary sterol intake. 2001 Am. J. Clin. Nutr. pmid:11451716
Burnett JR et al. Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis. 2001 Clin. Chim. Acta pmid:11282095
Sugama S et al. Frontal lobe dementia with abnormal cholesterol metabolism and heterozygous mutation in sterol 27-hydroxylase gene (CYP27). 2001 J. Inherit. Metab. Dis. pmid:11486904
Quilliot D et al. Phytosterols have an unfavourable effect on bacterial activity and no evident protective effect on colon carcinogenesis. 2001 Eur. J. Cancer Prev. pmid:11432710
Chaler R et al. Bile acids and sterols in urban sewage treatment plants. 2001 J Chromatogr A pmid:11572384
Inoue K et al. Cholestanol induces apoptosis of corneal endothelial and lens epithelial cells. 2000 Invest. Ophthalmol. Vis. Sci. pmid:10752932
Verrips A et al. Presence of diarrhea and absence of tendon xanthomas in patients with cerebrotendinous xanthomatosis. 2000 Arch. Neurol. pmid:10768627
Yan JL et al. Microbial transformation of 3-hydroxy-5,6-cyclopropanocholestanes--an alternative route to 6-methylsteroids. 2000 Steroids pmid:11077084
Friedman M et al. Lowering of plasma LDL cholesterol in hamsters by the tomato glycoalkaloid tomatine. 2000 Food Chem. Toxicol. pmid:10942315
Fleck JD et al. Neuroimages: cerebrotendinous xanthomatosis. 2000 Neurology pmid:10953208
Collinder E et al. Influence of bacitracin on microbial functions in the gastrointestinal tract of horses. 2000 Equine Vet. J. pmid:10952385
Miettinen TA et al. Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:10807752
Radhakrishnan A and McConnell HM Electric field effect on cholesterol-phospholipid complexes. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10655486
Björkhem I and Leitersdorf E Sterol 27-hydroxylase deficiency: a rare cause of xanthomas in normocholesterolemic humans. 2000 Trends Endocrinol. Metab. pmid:10856919
Radhakrishnan A et al. Condensed complexes, rafts, and the chemical activity of cholesterol in membranes. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:11050164
Collinder E et al. Six intestinal microflora-associated characteristics in sport horses. 2000 Equine Vet. J. pmid:10836477
Böttcher MF et al. Microflora-associated characteristics in faeces from allergic and nonallergic infants. 2000 Clin. Exp. Allergy pmid:11069568
Fernandes MB et al. Sedimentary 4-desmethyl sterols and n-alkanols in an eutrophic urban estuary, Capibaribe River, Brazil. 1999 Sci. Total Environ. pmid:10466230
Fadden K et al. Steroid metabolism along the gastrointestinal tract of the cannulated pig. 1999 Eur. J. Cancer Prev. pmid:10091041
Larking PW Cancer and low levels of plasma cholesterol: the relevance of cholesterol precursors and products to incidence of cancer. 1999 Prev Med pmid:10564630
Batta AK et al. Highly simplified method for gas-liquid chromatographic quantitation of bile acids and sterols in human stool. 1999 J. Lipid Res. pmid:10357847
Gylling H et al. Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. 1999 J. Lipid Res. pmid:10191283
Panda SK et al. Correlation of neomycin, faecal neutral and acid sterols with colon carcinogenesis in rats. 1999 Br. J. Cancer pmid:10376962
Radhakrishnan A and McConnell HM Condensed complexes of cholesterol and phospholipids. 1999 Biophys. J. pmid:10465761
Liendo A et al. Sterol composition and biosynthesis in Trypanosoma cruzi amastigotes. 1999 Mol. Biochem. Parasitol. pmid:10589983
Uchida K et al. Transformation of bile acids and sterols by clostridia (fusiform bacteria) in Wistar rats. 1999 Lipids pmid:10230721
Inoue K et al. Cholestanol induces apoptosis of cerebellar neuronal cells. 1999 Biochem. Biophys. Res. Commun. pmid:10066446
Gylling H et al. Oral guar gum treatment of intrahepatic cholestasis and pruritus in pregnant women: effects on serum cholestanol and other non-cholesterol sterols. 1998 Eur. J. Clin. Invest. pmid:9650008
Lin HS et al. Synthesis of 4 alpha-(2-propenyl)-5,6-secocholestan-3 alpha-ol, a novel B-ring seco analog of the hypocholesterolemic agent 4 alpha-(2-propenyl)-5 alpha-cholestan-3 alpha-ol. 1998 Steroids pmid:9589554
Kawabata M et al. Pulmonary manifestations in cerebrotendinous xanthomatosis. 1998 Intern. Med. pmid:9868952
Vanhoof K and De Schrijver R The influence of enzyme-resistant starch on cholesterol metabolism in rats fed on a conventional diet. 1998 Br. J. Nutr. pmid:9828761
Srikumar TS et al. Analysis of fecal bile acids and neutral steroids using gas-liquid chromatography. 1998 Ann. Nutr. Metab. pmid:9745109
Miettinen TA et al. Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study. Finnish 4S Investigators. 1998 BMJ pmid:9552949
Wallis EJ et al. Cholestanol and survival with simvastatin. More data are needed. 1998 BMJ pmid:9794879
Reddy S et al. Faecal pH, bile acid and sterol concentrations in premenopausal Indian and white vegetarians compared with white omnivores. 1998 Br. J. Nutr. pmid:9771336