Coprosterol

Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.

Cross Reference

Introduction

To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coprosterol?

Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coprosterol

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Alcoholism D000437 27 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Coprosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coprosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coprosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coprosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Coprosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coprosterol?

Rodent Model

Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coprosterol

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Authors Title Published Journal PubMed Link
Said J et al. Lipophile-conjugated sulfated oligosaccharides as novel microbicides against HIV-1. 2010 Antiviral Res. pmid:20307578
Midtvedt T et al. Intestinal microbial conversion of cholesterol to coprostanol in man. Influence of antibiotics. 1990 APMIS pmid:2223037
Isobe KO et al. Effect of environmental factors on the relationship between concentrations of coprostanol and fecal indicator bacteria in tropical (Mekong Delta) and temperate (Tokyo) freshwaters. 2004 Appl. Environ. Microbiol. pmid:14766559
Midtvedt T et al. Establishment of a biochemically active intestinal ecosystem in ex-germfree rats. 1987 Appl. Environ. Microbiol. pmid:3124742
Mott GE et al. Biochemical characterization of cholesterol-reducing Eubacterium. 1980 Appl. Environ. Microbiol. pmid:6779702
Sadzikowski MR et al. Cholesterol-reducing bacterium from human feces. 1977 Appl. Environ. Microbiol. pmid:335969
Parker F Normocholesterolemic xanthomatosis. 1986 Arch Dermatol pmid:3096220
WELLS WW Coprostanol formation. I. The effect of sodium taurocholate and Tween 80 on the sterol composition of rat feces. 1957 Arch. Biochem. Biophys. pmid:13395541
WELLS WW and COOPER SB Coprostanol formation. II. The opposing action of dietary lactose and calcium on cholesterol absorption. 1958 Arch. Biochem. Biophys. pmid:13534706
VAHOUNY GV et al. Comparison of lymphatic absorption of dihydrocholesterol and cholesterol in the rat. 1960 Arch. Biochem. Biophys. pmid:13840683
MOSBACH EH and BEVANS M Formation of gall stones in rabbits fed 3beta-cholestanol. 1956 Arch. Biochem. Biophys. pmid:13341064
ROSENFELD RS THE ISOLATION OF COPROSTANOL FROM STEROL ESTERS OF HUMAN FECES. 1964 Arch. Biochem. Biophys. pmid:14244675
COLEMAN DL et al. Intestinal sterols. II. Determination of coprostanol and certain related sterols. 1956 Arch. Biochem. Biophys. pmid:13292920
Moghadasian MH et al. Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations. 2002 Arch. Neurol. pmid:11939886
Verrips A et al. Presence of diarrhea and absence of tendon xanthomas in patients with cerebrotendinous xanthomatosis. 2000 Arch. Neurol. pmid:10768627
Katz DA et al. Peripheral neuropathy in cerebrotendinous xanthomatosis. 1985 Arch. Neurol. pmid:2994606
Monson DM et al. Cerebrotendinous xanthomatosis: a treatable disease with juvenile cataracts as a presenting sign. 2011 Arch. Ophthalmol. pmid:21825196
Tészás A et al. Presenile cataract: consider cholestanol. 2006 Arch. Ophthalmol. pmid:17030721
Miettinen TA et al. Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:10807752
van Himbergen TM et al. Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19834104