Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moraes EA et al. | Delivering cholesterol or cholestanol to bull sperm membranes improves cryosurvival. | 2010 | Anim. Reprod. Sci. | pmid:19733986 |
| Moraes EA et al. | Cholestanol-loaded-cyclodextrin improves the quality of stallion spermatozoa after cryopreservation. | 2015 | Anim. Reprod. Sci. | pmid:26005214 |
| Brunnekreeft JW et al. | Direct determination of total serum cholesterol by on-column gas-liquid chromatographic analysis without previous derivatisation compared with WHO-CDC reference method. | 1983 | Ann. Clin. Biochem. | pmid:6418055 |
| Norin E | Intestinal cholesterol conversion in adults and elderly from four different European countries. | 2008 | Ann. Nutr. Metab. | pmid:18382071 |
| Andriamiarina R et al. | Effects of stigmasterol-supplemented diets on fecal neutral sterols and bile acid excretion in rats. | 1989 | Ann. Nutr. Metab. | pmid:2516429 |
| Srikumar TS et al. | Analysis of fecal bile acids and neutral steroids using gas-liquid chromatography. | 1998 | Ann. Nutr. Metab. | pmid:9745109 |
| Watne AL et al. | The occurrence of carcinoma of the rectum following ileoproctostomy for familial polyposis. | 1983 | Ann. Surg. | pmid:6847274 |
| Valayil JM et al. | Isolation, Purification and Characterization of a Novel Steroidal Saponin Cholestanol Glucoside from Lasiodiplodia theobromae that Induces Apoptosis in A549 Cells. | 2016 | Anticancer Agents Med Chem | pmid:26338072 |
| Rodrigues JC et al. | Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis. | 2002 | Antimicrob. Agents Chemother. | pmid:11796362 |
| Urbina JA et al. | Inhibitors of delta24(25) sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii. | 1997 | Antimicrob. Agents Chemother. | pmid:9210660 |