Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chaler R et al. | Bile acids and sterols in urban sewage treatment plants. | 2001 | J Chromatogr A | pmid:11572384 |
| Mondelli M et al. | Cerebrotendinous xanthomatosis: 11-year treatment with chenodeoxycholic acid in five patients. An electrophysiological study. | 2001 | J. Neurol. Sci. | pmid:11574103 |
| Gagné F et al. | Evidence of coprostanol estrogenicity to the freshwater mussel Elliptio complanata. | 2001 | Environ. Pollut. | pmid:11586778 |
| Brämswig S et al. | Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11788421 |
| Rodrigues JC et al. | Ultrastructural and biochemical alterations induced by 22,26-azasterol, a delta(24(25))-sterol methyltransferase inhibitor, on promastigote and amastigote forms of Leishmania amazonensis. | 2002 | Antimicrob. Agents Chemother. | pmid:11796362 |
| Gylling H and Miettinen TA | Baseline intestinal absorption and synthesis of cholesterol regulate its response to hypolipidaemic treatments in coronary patients. | 2002 | Atherosclerosis | pmid:11849674 |
| Bull ID et al. | The origin of faeces by means of biomarker detection. | 2002 | Environ Int | pmid:11934114 |
| Moghadasian MH et al. | Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations. | 2002 | Arch. Neurol. | pmid:11939886 |
| Petucci C et al. | Differentiation of stereoisomeric steroids by reactions with phosphenium ions. | 2002 | J. Am. Soc. Mass Spectrom. | pmid:11951974 |
| Lamon-Fava S et al. | Two novel mutations in the sterol 27-hydroxylase gene causing cerebrotendinous xanthomatosis. | 2002 | Clin. Genet. | pmid:12000359 |