Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| ROSENFELD RS | THE ISOLATION OF COPROSTANOL FROM STEROL ESTERS OF HUMAN FECES. | 1964 | Arch. Biochem. Biophys. | pmid:14244675 |
| SHEFER S et al. | BIOSYNTHESIS OF 5-ALPHA-CHOLESTAN-3-BETA-OL IN RAT AND GUINEA PIG LIVER IN VITRO. | 1965 | J. Lipid Res. | pmid:14280469 |
| Rosenfeld RS | Analysis of sterol extracts for cholestanol. | 1965 | Anal. Biochem. | pmid:5323673 |
| Schubert K and Kaufmann G | [Formation of sterol esters in bacterial cells]. | 1965 | Biochim. Biophys. Acta | pmid:5326537 |
| BELL RG et al. | BILE ACIDS. XX. METABOLISM OF COPROSTANOL-4-14C IN THE RAT. | 1965 | J. Biol. Chem. | pmid:14284701 |
| TRUSWELL AS and MITCHELL WD | SEPARATION OF CHOLESTEROL FROM ITS COMPANIONS, CHOLESTANOL AND DELTA-7-CHOLESTENOL, BY THIN-LAYER CHROMATOGRAPHY. | 1965 | J. Lipid Res. | pmid:14336218 |
| Takiguchi H et al. | Suppression of cholesterol synthesis in rat liver by dihydrocholesterol administration. | 1966 | J. Biochem. | pmid:4860849 |
| Rosenfeld RS et al. | Conversion of cholesterol injected into man to cholestanol via a 3-ketonic intermediate. | 1967 | J. Lipid Res. | pmid:14564700 |
| Rothblat GH and Kritchevsky D | The excretion of free and ester cholesterol by tissue culture cells: studies with L5178Y and L-cells. | 1967 | Biochim. Biophys. Acta | pmid:4863609 |
| Swanson PD | Cerebrotendinous xanthomatosis. | 1968 | N. Engl. J. Med. | pmid:4868195 |