Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Simonen PP et al. | Body weight modulates cholesterol metabolism in non-insulin dependent type 2 diabetics. | 2002 | Obes. Res. | pmid:12006631 |
| Nakajima N et al. | Biosynthesis of cholestanol in higher plants. | 2002 | Phytochemistry | pmid:12031446 |
| Collinder E et al. | Biochemical intestinal parameters in pigs reared outdoors and indoors, and in germ-free pigs. | 2002 | J Vet Med A Physiol Pathol Clin Med | pmid:12069263 |
| Schönning C et al. | Faecal contamination of source-separated human urine based on the content of faecal sterols. | 2002 | Water Res. | pmid:12092571 |
| Okonogi TM et al. | Two fatty acids can replace one phospholipid in condensed complexes with cholesterol. | 2002 | Biochim. Biophys. Acta | pmid:12100988 |
| Gagné F et al. | Biomarker study of a municipal effluent dispersion plume in two species of freshwater mussels. | 2002 | Environ. Toxicol. | pmid:12112623 |
| von Bahr S et al. | Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). | 2002 | Arterioscler. Thromb. Vasc. Biol. | pmid:12117727 |
| Miettinen TA and Gylling H | Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients. | 2002 | Atherosclerosis | pmid:12119203 |
| Cruz JC et al. | Synthesis and biochemical properties of a new photoactivatable cholesterol analog 7,7-azocholestanol and its linoleate ester in Chinese hamster ovary cell lines. | 2002 | J. Lipid Res. | pmid:12177179 |
| Radhakrishnan A and McConnell HM | Critical points in charged membranes containing cholesterol. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12368466 |