Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.
To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Coprosterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Brain Diseases, Metabolic | D001928 | 9 associated lipids |
| Biliary Fistula | D001658 | 13 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Freston JW and Bouchier IA | Experimental cholelithiasis. | 1968 | Gut | pmid:4867933 |
| Dennis VW et al. | Molecular aspects of polyene- and sterol-dependent pore formation in thin lipid membranes. | 1970 | J. Gen. Physiol. | pmid:4938534 |
| Kamel AM et al. | Identification of cholesteryl nitrate as a product of the reaction between NO 2 and cholesterol monomolecular films. | 1971 | Chem. Phys. Lipids | pmid:4937038 |
| Salen G and Polito A | Biosynthesis of 5 -cholestan-3 -ol in cerebrotendinous xanthomatosis. | 1972 | J. Clin. Invest. | pmid:4550120 |
| Norman AW et al. | Studies on the biological properties of polyene antibiotics: comparison of other polyenes with filipin in their ability to interact specifically with sterol. | 1972 | Biochim. Biophys. Acta | pmid:4565643 |
| Ghosh D and Tinoco J | Monolayer interactions of individual lecithins with natural sterols. | 1972 | Biochim. Biophys. Acta | pmid:4557356 |
| Smith AG et al. | The intermediacy of 3-oxo steroids in the conversion of cholest-5-en-3 -ol into 5 -cholestan-3 -ol by the starfish Asterias rubens and Porania pulvillus. | 1972 | Biochem. J. | pmid:4566194 |
| Eyssen H et al. | Role of the cecum in maintaing 5 -steroid- and fatty acid-reducing activity of the rat intestinal microflora. | 1972 | J. Nutr. | pmid:4563003 |
| Horton BJ et al. | Abnormal cholesterol uptake, storage, and synthesis in the livers of 2-acetylaminofluorene-fed rats. | 1973 | Cancer Res. | pmid:4578071 |
| Salen G and Grundy SM | The metabolism of cholestanol, cholesterol, and bile acids in cerebrotendinous xanthomatosis. | 1973 | J. Clin. Invest. | pmid:4355999 |