Coprosterol

Coprosterol is a lipid of Sterol Lipids (ST) class. Coprosterol is associated with abnormalities such as Cerebrovascular accident, Glycogen Storage Disease Type IV, Coronary Arteriosclerosis, CARDIAC EVENT and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as cholesterol absorption, Death, Sudden, Cardiac, Drug Interactions, Cholesterol Homeostasis and Synthesis. Coprosterol often locates in lipid raft, Tissue membrane, Membrane, Blood and Body tissue. The associated genes with Coprosterol are ABO gene, STN gene, Alleles, Apolipoprotein E gene and TNF gene. The related lipids are saturated fat, campesterol, lathosterol, Sterols and Total cholesterol. The related experimental models are Rodent Model.

Cross Reference

Introduction

To understand associated biological information of Coprosterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Coprosterol?

Coprosterol is suspected in Coronary Arteriosclerosis, Cerebrovascular accident, Glycogen Storage Disease Type IV, CARDIAC EVENT, Diabetes Mellitus, Non-Insulin-Dependent, Niemann-Pick Diseases and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Coprosterol

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Cataract D002386 34 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Alcoholism D000437 27 associated lipids
Brain Diseases, Metabolic D001928 9 associated lipids
Biliary Fistula D001658 13 associated lipids
Xanthomatosis D014973 17 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Coprosterol

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Coprosterol?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Coprosterol?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Coprosterol?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Coprosterol?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Coprosterol?

Rodent Model

Rodent Model are used in the study 'Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome.' (Keller RK et al., 2004).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Coprosterol

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Authors Title Published Journal PubMed Link
Dantas-Leite L et al. Antiproliferative synergism of azasterols and antifolates against Toxoplasma gondii. 2005 Int. J. Antimicrob. Agents pmid:15664482
Clarenbach JJ et al. Isotopomer spectral analysis of intermediates of cholesterol synthesis in patients with cerebrotendinous xanthomatosis. 2005 Metab. Clin. Exp. pmid:15736111
Cardona ME et al. Biochemical intestinal parameters in germ-free minipigs and rats and in ex-germ-free minipigs and rats monoassociated with Escherichia coli. 2005 J Vet Med A Physiol Pathol Clin Med pmid:15836440
Readman JW et al. The use of steroid markers to assess sewage contamination of the Black Sea. 2005 Mar. Pollut. Bull. pmid:15757694
Clemen CS et al. Cerebrotendinous xanthomatosis: a treatable ataxia. 2005 Neurology pmid:15851751
Corradini SG et al. Comparison of changes in lipid profile after bilio-intestinal bypass and gastric banding in patients with morbid obesity. 2005 Obes Surg pmid:15826472
Veiga P et al. Correlation between faecal microbial community structure and cholesterol-to-coprostanol conversion in the human gut. 2005 FEMS Microbiol. Lett. pmid:15621423
Lindenthal B et al. Serum lipid analysis confirms the diagnosis of X-linked dominant chondrodysplasia punctata - Conradi-Hünermann-Happle syndrome. 2004 Mar-Apr Klin Padiatr pmid:15106076
Bartholdi D et al. Spinal phenotype of cerebrotendinous xanthomatosis--a pitfall in the diagnosis of multiple sclerosis. 2004 J. Neurol. pmid:14999499
Hughes KA and Thompson A Distribution of sewage pollution around a maritime Antarctic research station indicated by faecal coliforms, Clostridium perfringens and faecal sterol markers. 2004 Environ. Pollut. pmid:14638291
Dongowski G and Lorenz A Intestinal steroids in rats are influenced by the structural parameters of pectin. 2004 J. Nutr. Biochem. pmid:15068812
Okonogi TM and McConnell HM Contrast inversion in the epifluorescence of cholesterol-phospholipid monolayers. 2004 Biophys. J. pmid:14747323
Gérard P et al. Gnotobiotic rats harboring human intestinal microbiota as a model for studying cholesterol-to-coprostanol conversion. 2004 FEMS Microbiol. Ecol. pmid:19712322
Moghadasian MH Cerebrotendinous xanthomatosis: clinical course, genotypes and metabolic backgrounds. 2004 Clin Invest Med pmid:15061585
Rontani JF and Aubert C Electron ionization mass spectral fragmentation of derivatized 4,5- and 5,6-epoxysterols. 2004 Rapid Commun. Mass Spectrom. pmid:15116422
Dotti MT et al. Normalisation of serum cholestanol concentration in a patient with cerebrotendinous xanthomatosis by combined treatment with chenodeoxycholic acid, simvastatin and LDL apheresis. 2004 Neurol. Sci. pmid:15549503
Isobe KO et al. Effect of environmental factors on the relationship between concentrations of coprostanol and fecal indicator bacteria in tropical (Mekong Delta) and temperate (Tokyo) freshwaters. 2004 Appl. Environ. Microbiol. pmid:14766559
Dantas-Leite L et al. Selective anti-Toxoplasma gondii activities of azasterols. 2004 Int. J. Antimicrob. Agents pmid:15194134
Ohgami N et al. Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15314240
Keller S and Jahreis G Determination of underivatised sterols and bile acid trimethyl silyl ether methyl esters by gas chromatography-mass spectrometry-single ion monitoring in faeces. 2004 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:15556534
Keller RK et al. Formation of 7-dehydrocholesterol-containing membrane rafts in vitro and in vivo, with relevance to the Smith-Lemli-Opitz syndrome. 2004 J. Lipid Res. pmid:14594996
Berger A et al. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. 2004 Lipids Health Dis pmid:14969592
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Puglisi E et al. Cholesterol, beta-sitosterol, ergosterol, and coprostanol in agricultural soils. 2003 Mar-Apr J. Environ. Qual. pmid:12708669
Dongowski G et al. Steroids in the intestinal tract of rats are affected by dietary-fibre-rich barley-based diets. 2003 Br. J. Nutr. pmid:14667183
Schief WR et al. Liquid-crystalline collapse of pulmonary surfactant monolayers. 2003 Biophys. J. pmid:12770885
Hellou J et al. Chemical contaminants and biological indicators of mussel health during gametogenesis. 2003 Environ. Toxicol. Chem. pmid:12959534
Nimmo MR and Cross NL Structural features of sterols required to inhibit human sperm capacitation. 2003 Biol. Reprod. pmid:12606419
Bortolomeazzi R et al. Presence of phytosterol oxides in crude vegetable oils and their fate during refining. 2003 J. Agric. Food Chem. pmid:12670187
Norlin M et al. On the substrate specificity of human CYP27A1: implications for bile acid and cholestanol formation. 2003 J. Lipid Res. pmid:12777473
Wiegand V et al. Transport of plasma membrane-derived cholesterol and the function of Niemann-Pick C1 Protein. 2003 FASEB J. pmid:12594172
Cao H et al. Unraveling the mystery surrounding cholesterol's condensing effect. 2003 J. Am. Chem. Soc. pmid:14692747
Ward JN et al. Feeding of benthic foraminifera on diatoms and sewage-derived organic matter: an experimental application of lipid biomarker techniques. 2003 Mar. Environ. Res. pmid:12860436
Ottoson J and Stenström TA Faecal contamination of greywater and associated microbial risks. 2003 Water Res. pmid:12688699
Jaffé R et al. Organic compounds and trace metals of anthropogenic origin in sediments from Montego Bay, Jamaica: assessment of sources and distribution pathways. 2003 Environ. Pollut. pmid:12628208
Antonio González Oreja J and Ignacio Saiz Salinas J Recovery simulations of grossly polluted sediments in the Bilbao Estuary. 2003 Mar. Pollut. Bull. pmid:12535968
Ito S et al. Combined treatment with LDL-apheresis, chenodeoxycholic acid and HMG-CoA reductase inhibitor for cerebrotendinous xanthomatosis. 2003 J. Neurol. Sci. pmid:14607320
Collinder E et al. Influence of zinc bacitracin and Bacillus licheniformis on microbial intestinal functions in weaned piglets. 2003 Vet. Res. Commun. pmid:14609263
Addona GH et al. Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site. 2003 Biochim. Biophys. Acta pmid:12543379
Seyama Y Cholestanol metabolism, molecular pathology, and nutritional implications. 2003 J Med Food pmid:14585188
Miettinen TA et al. Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. 2003 J. Lab. Clin. Med. pmid:12577049
Yu L et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12444248
Petucci C et al. Differentiation of stereoisomeric steroids by reactions with phosphenium ions. 2002 J. Am. Soc. Mass Spectrom. pmid:11951974
Bull ID et al. The origin of faeces by means of biomarker detection. 2002 Environ Int pmid:11934114
Moghadasian MH et al. Cerebrotendinous xanthomatosis: a rare disease with diverse manifestations. 2002 Arch. Neurol. pmid:11939886
Gylling H and Miettinen TA Baseline intestinal absorption and synthesis of cholesterol regulate its response to hypolipidaemic treatments in coronary patients. 2002 Atherosclerosis pmid:11849674
Radhakrishnan A and McConnell HM Critical points in charged membranes containing cholesterol. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12368466
Cruz JC et al. Synthesis and biochemical properties of a new photoactivatable cholesterol analog 7,7-azocholestanol and its linoleate ester in Chinese hamster ovary cell lines. 2002 J. Lipid Res. pmid:12177179
Schönning C et al. Faecal contamination of source-separated human urine based on the content of faecal sterols. 2002 Water Res. pmid:12092571
Lamon-Fava S et al. Two novel mutations in the sterol 27-hydroxylase gene causing cerebrotendinous xanthomatosis. 2002 Clin. Genet. pmid:12000359