MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
MeSH term | MeSH ID | Detail |
---|---|---|
Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yoshida K et al. | Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. | 2018 | Andrologia | pmid:28295471 |
Yi M et al. | Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28729181 |
Li J et al. | Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis. | 2017 | Reprod. Biol. Endocrinol. | pmid:28302174 |
Venugopal S et al. | Plasma Membrane Origin of the Steroidogenic Pool of Cholesterol Used in Hormone-induced Acute Steroid Formation in Leydig Cells. | 2016 | J. Biol. Chem. | pmid:27815506 |
Kim H et al. | 22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca(2+)/PKCα signaling. | 2016 | Biochim. Biophys. Acta | pmid:27206966 |
Ceroi A et al. | The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation. | 2016 | Haematologica | pmid:26635040 |
Huwait EA et al. | Protein Kinase C Is Involved in the Induction of ATP-Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages. | 2015 | J. Cell. Biochem. | pmid:25752819 |
Newby EA et al. | Adrenocorticotropic Hormone and PI3K/Akt Inhibition Reduce eNOS Phosphorylation and Increase Cortisol Biosynthesis in Long-Term Hypoxic Ovine Fetal Adrenal Cortical Cells. | 2015 | Reprod Sci | pmid:25656500 |
Na TY et al. | 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. | 2015 | J. Pathol. | pmid:25557254 |
Davydov R et al. | Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies. | 2015 | Biochemistry | pmid:26603348 |