MeSH term | MeSH ID | Detail |
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Arteriosclerosis | D001161 | 86 associated lipids |
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
MeSH term | MeSH ID | Detail |
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Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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El Roz A et al. | LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis. | 2012 | Anticancer Res. | pmid:22753765 |
Hessvik NP et al. | The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism. | 2012 | J. Steroid Biochem. Mol. Biol. | pmid:22051079 |
Lecanu L et al. | A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo. | 2012 | Steroids | pmid:22138207 |
GarcÃa MM et al. | Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc. | 2012 | Chem. Biol. Interact. | pmid:22940207 |
Kittayaruksakul S et al. | Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:22169006 |
Tranheim Kase E et al. | Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. | 2012 | Lipids | pmid:22426832 |
Valbuena-Diez AC et al. | Oxysterol-induced soluble endoglin release and its involvement in hypertension. | 2012 | Circulation | pmid:23110859 |
Soodvilai S et al. | Liver X receptor agonists decrease ENaC-mediated sodium transport in collecting duct cells. | 2012 | Am. J. Physiol. Renal Physiol. | pmid:23077096 |
Kumar R et al. | Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo. | 2012 | Exp. Dermatol. | pmid:23163651 |
Ortega I et al. | Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells. | 2012 | Biol. Reprod. | pmid:21918126 |