MeSH term | MeSH ID | Detail |
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Arteriosclerosis | D001161 | 86 associated lipids |
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
MeSH term | MeSH ID | Detail |
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Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Qu JH et al. | Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway. | 2008 | Toxicol. Lett. | pmid:18053657 |
Wang YB et al. | Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1). | 2007 | J. Toxicol. Environ. Health Part A | pmid:17479410 |
Yao ZX et al. | 22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells. | 2007 | Neuroscience | pmid:17689017 |
Cheng S et al. | Carbaryl inhibits basal and FSH-induced progesterone biosynthesis of primary human granulosa-lutein cells. | 2006 | Toxicology | pmid:16413094 |
Deng R et al. | Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16371446 |
Kase ET et al. | 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes. | 2006 | Biochim. Biophys. Acta | pmid:17055780 |
Supornsilchai V et al. | Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein. | 2006 | Reprod. Toxicol. | pmid:16777379 |
Allen JA et al. | Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. | 2006 | Endocrinology | pmid:16690799 |
Piraino G et al. | Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. | 2006 | Shock | pmid:16878022 |
Shouhed D et al. | Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells. | 2005 | J. Cell. Biochem. | pmid:15880703 |