MeSH term | MeSH ID | Detail |
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Arteriosclerosis | D001161 | 86 associated lipids |
22(r)-hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 22(r)-hydroxycholesterol is associated with abnormalities such as Transient Ischemic Attack, Still, Neurodegenerative Disorders and Senile Plaques. The involved functions are known as Binding (Molecular Function), inhibitors, mRNA Expression, Gene Expression and Transcription, Genetic. 22(r)-hydroxycholesterol often locates in Blood, Protoplasm, Extracellular, Cytosol and Cytoplasm. The associated genes with 22(r)-hydroxycholesterol are CCL2 gene, IL8RB gene, CALCA gene and GRM5 gene. The related lipids are 22-hydroxycholesterol, Lipopolysaccharides, 15-deoxyprostaglandin J2 and 7-ketocholesterol.
To understand associated biological information of 22(r)-hydroxycholesterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22(r)-hydroxycholesterol is suspected in Neurodegenerative Disorders, Transient Ischemic Attack, Senile Plaques and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with 22(r)-hydroxycholesterol
MeSH term | MeSH ID | Detail |
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Arteriosclerosis | D001161 | 86 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Cheng J et al. | The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. | 2003 | Toxicology | pmid:12699903 |
Hsu CC et al. | Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. | 2003 | FEBS Lett. | pmid:12753921 |
Ide T et al. | Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. | 2003 | Mol. Endocrinol. | pmid:12730332 |
Koldamova RP et al. | 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. | 2003 | J. Biol. Chem. | pmid:12547833 |
Nguyen DH and Taub DD | Membrane incorporation of 22-hydroxycholesterol inhibits chemokine receptor activity. | 2003 | Exp. Cell Res. | pmid:12706121 |
Fowler AJ et al. | Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. | 2003 | J. Invest. Dermatol. | pmid:12542530 |
Xia H and Redman CM | Oxysterols suppress constitutive fibrinogen expression. | 2003 | Thromb. Haemost. | pmid:12876624 |
Kaneko E et al. | Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. | 2003 | J. Biol. Chem. | pmid:12847102 |
Nazarov PA et al. | Formation and functioning of fused cholesterol side-chain cleavage enzymes. | 2003 | DNA Cell Biol. | pmid:12823901 |
Thiboutot D et al. | Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). | 2003 | J. Invest. Dermatol. | pmid:12787114 |