27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang J et al. | 7 alpha-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts. | 1995 | Biochim. Biophys. Acta | pmid:7786899 |
| Axelson M et al. | Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. | 1995 | J. Lipid Res. | pmid:7751816 |
| Sauter G et al. | Formation of cholic acid and chenodeoxycholic acid from 7 alpha-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes. | 1996 | Biochim. Biophys. Acta | pmid:8608157 |
| Winegar DA et al. | Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells. | 1996 | J. Lipid Res. | pmid:8820113 |
| Lee C et al. | Bile acid synthesis: 7 alpha-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway. | 1996 | J. Lipid Res. | pmid:8808770 |
| Tsankova V et al. | Peripheral benzodiazepine receptor ligands in rat liver mitochondria: effect on 27-hydroxylation of cholesterol. | 1996 | Eur. J. Pharmacol. | pmid:8901023 |
| Reiss AB et al. | Sterol 27-hydroxylase: expression in human arterial endothelium. | 1997 | J. Lipid Res. | pmid:9215552 |
| Xiu R et al. | [Elimination of cholesterol in human endothelial cells]. | 1997 | Zhonghua Yi Xue Za Zhi | pmid:9772537 |
| Zhou Q and Kummerow FA | Effect of 27-hydroxycholesterol on cellular sphingomyelin synthesis and Ca++ content in cultured smooth muscle cells. | 1997 | Biomed. Environ. Sci. | pmid:9448918 |
| Crisby M et al. | Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques. | 1997 | Biochim. Biophys. Acta | pmid:9059518 |