27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcoholism | D000437 | 27 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vini R et al. | Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27-hydroxycholesterol. | 2016 | IUBMB Life | pmid:26756990 |
| Umetani M | Re-adopting classical nuclear receptors by cholesterol metabolites. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:26563834 |
| Mignarri A et al. | Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. | 2016 | J. Inherit. Metab. Dis. | pmid:26153518 |
| Liu Q et al. | Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. | 2016 | Lipids Health Dis | pmid:27724967 |
| Zhu D et al. | The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells. | 2016 | Toxicol. Lett. | pmid:27856279 |
| Ma LM et al. | 27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751849 |
| Wang H et al. | The cytotoxicity of 27-hydroxycholesterol in co-cultured SH-SY5Y cells and C6 cells. | 2016 | Neurosci. Lett. | pmid:27592060 |
| Rocha G et al. | [27- Hydroxycholesterol reverses estradiol induced inhibition of platelet aggregation in postmenopausal women]. | 2016 | Rev Med Chil | pmid:28394953 |
| Hashimoto Y et al. | 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27036870 |
| Stellaard F et al. | The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27060336 |
| Schöls L et al. | Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. | 2017 | Brain | pmid:29126212 |
| Cagno V et al. | Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2017 | Redox Biol | pmid:28359048 |
| Cardenia V et al. | Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27084531 |
| Brooks SW et al. | A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus. | 2017 | J. Alzheimers Dis. | pmid:27911307 |
| Kim BY et al. | Dexamethasone inhibits activation of monocytes/macrophages in a milieu rich in 27-oxygenated cholesterol. | 2017 | PLoS ONE | pmid:29236764 |
| Marwarha G et al. | 27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. | 2017 | Chem. Phys. Lipids | pmid:28583434 |
| Roberg-Larsen H et al. | Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26877254 |
| Oguro H et al. | 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. | 2017 | J. Clin. Invest. | pmid:28783041 |
| Heverin M et al. | On the regulatory importance of 27-hydroxycholesterol in mouse liver. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26851362 |
| Ismail MA et al. | 27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation. | 2017 | J. Exp. Med. | pmid:28213512 |