27-hydroxy-cholesterol(25R)

27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.

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Introduction

To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 27-hydroxy-cholesterol(25R)?

27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)

MeSH term MeSH ID Detail
Alcoholism D000437 27 associated lipids
Alzheimer Disease D000544 76 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with 27-hydroxy-cholesterol(25R)

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 27-hydroxy-cholesterol(25R)?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 27-hydroxy-cholesterol(25R)?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 27-hydroxy-cholesterol(25R)?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 27-hydroxy-cholesterol(25R)?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 27-hydroxy-cholesterol(25R)?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 27-hydroxy-cholesterol(25R)

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Authors Title Published Journal PubMed Link
Leoni V and Caccia C Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. 2013 Biochem. Pharmacol. pmid:23541982
Nunes VS et al. Plasma 27-hydroxycholesterol/cholesterol ratio is increased in low high density lipoprotein-cholesterol healthy subjects. 2013 Clin. Biochem. pmid:23850851
Freemantle E et al. Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. 2013 Int. J. Neuropsychopharmacol. pmid:23369504
Kim SM et al. 27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages. 2013 Biochem. Biophys. Res. Commun. pmid:23246833
Baker ME What are the physiological estrogens? 2013 Steroids pmid:23313336
Bieghs V et al. The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. 2013 Gastroenterology pmid:23041327
Marwarha G et al. Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells. 2013 PLoS ONE pmid:23951005
Kaiser J Cancer. Cholesterol forges link between obesity and breast cancer. 2013 Science pmid:24288308
Nelson ER et al. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. 2013 Science pmid:24288332
Ragot K et al. Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. 2013 Biochem. Pharmacol. pmid:23473804