27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcoholism | D000437 | 27 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nunes VS et al. | Plasma 27-hydroxycholesterol/cholesterol ratio is increased in low high density lipoprotein-cholesterol healthy subjects. | 2013 | Clin. Biochem. | pmid:23850851 |
| Freemantle E et al. | Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. | 2013 | Int. J. Neuropsychopharmacol. | pmid:23369504 |
| Kim SM et al. | 27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23246833 |
| Baker ME | What are the physiological estrogens? | 2013 | Steroids | pmid:23313336 |
| Bieghs V et al. | The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. | 2013 | Gastroenterology | pmid:23041327 |
| Marwarha G et al. | Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells. | 2013 | PLoS ONE | pmid:23951005 |
| Kaiser J | Cancer. Cholesterol forges link between obesity and breast cancer. | 2013 | Science | pmid:24288308 |
| Nelson ER et al. | 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. | 2013 | Science | pmid:24288332 |
| Acimovic J et al. | Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. | 2013 | PLoS ONE | pmid:23844150 |
| Ragot K et al. | Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. | 2013 | Biochem. Pharmacol. | pmid:23473804 |