Stellaard F et al. |
The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:27060336
|
Schöls L et al. |
Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. |
2017 |
Brain |
pmid:29126212
|
Cagno V et al. |
Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. |
2017 |
Redox Biol |
pmid:28359048
|
Cardenia V et al. |
Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:27084531
|
Baek AE et al. |
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. |
2017 |
Nat Commun |
pmid:29021522
|
He S and Nelson ER |
27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator. |
2017 |
Maturitas |
pmid:28923174
|
Kimbung S et al. |
Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. |
2017 |
Endocr. Relat. Cancer |
pmid:28442559
|
Mistry HD et al. |
Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia. |
2017 |
J. Lipid Res. |
pmid:28396342
|
An Y et al. |
27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells. |
2017 |
Neurotoxicology |
pmid:28167099
|
Winkler BS et al. |
Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies. |
2017 |
BMC Pregnancy Childbirth |
pmid:28376740
|
Brooks SW et al. |
A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus. |
2017 |
J. Alzheimers Dis. |
pmid:27911307
|
Kim BY et al. |
Dexamethasone inhibits activation of monocytes/macrophages in a milieu rich in 27-oxygenated cholesterol. |
2017 |
PLoS ONE |
pmid:29236764
|
Marwarha G et al. |
27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. |
2017 |
Chem. Phys. Lipids |
pmid:28583434
|
Kim BY et al. |
27-Hydroxycholesterol upregulates the production of heat shock protein 60 of monocytic cells. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:28549691
|
Shen Z et al. |
27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3. |
2017 |
Environ. Toxicol. Pharmacol. |
pmid:28257824
|
Alfaqih MA et al. |
CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. |
2017 |
Cancer Res. |
pmid:28130224
|
Roberg-Larsen H et al. |
Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:26877254
|
Oguro H et al. |
27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. |
2017 |
J. Clin. Invest. |
pmid:28783041
|
Heverin M et al. |
On the regulatory importance of 27-hydroxycholesterol in mouse liver. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:26851362
|
Ismail MA et al. |
27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation. |
2017 |
J. Exp. Med. |
pmid:28213512
|
Vurusaner B et al. |
Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells. |
2016 |
Free Radic. Biol. Med. |
pmid:26689473
|
Vini R et al. |
Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27-hydroxycholesterol. |
2016 |
IUBMB Life |
pmid:26756990
|
Ehrhardt M et al. |
Expression of human CYP27A1 in B. megaterium for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol. |
2016 |
J. Biotechnol. |
pmid:26638999
|
Umetani M |
Re-adopting classical nuclear receptors by cholesterol metabolites. |
2016 |
J. Steroid Biochem. Mol. Biol. |
pmid:26563834
|
Nelson ER |
Detection of Endogenous Selective Estrogen Receptor Modulators such as 27-Hydroxycholesterol. |
2016 |
Methods Mol. Biol. |
pmid:26585155
|
Mignarri A et al. |
Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. |
2016 |
J. Inherit. Metab. Dis. |
pmid:26153518
|
Pataj Z et al. |
Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. |
2016 |
J Chromatogr A |
pmid:26607314
|
Liu Q et al. |
Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. |
2016 |
Lipids Health Dis |
pmid:27724967
|
Wang HL et al. |
Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. |
2016 |
J. Alzheimers Dis. |
pmid:26836015
|
Zhu D et al. |
The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells. |
2016 |
Toxicol. Lett. |
pmid:27856279
|
Perone Y and Magnani L |
Going off the grid: ERα breast cancer beyond estradiol. |
2016 |
J. Mol. Endocrinol. |
pmid:27151575
|
Ma LM et al. |
27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells. |
2016 |
Biochem. Biophys. Res. Commun. |
pmid:27751849
|
Wang H et al. |
The cytotoxicity of 27-hydroxycholesterol in co-cultured SH-SY5Y cells and C6 cells. |
2016 |
Neurosci. Lett. |
pmid:27592060
|
Kim BY et al. |
Diclofenac inhibits 27-hydroxycholesterol-induced inflammation. |
2016 |
Biochem. Biophys. Res. Commun. |
pmid:27576203
|
Wu Y et al. |
Liver X receptor as a drug target for the treatment of breast cancer. |
2016 |
Anticancer Drugs |
pmid:26872310
|
Rocha G et al. |
[27- Hydroxycholesterol reverses estradiol induced inhibition of platelet aggregation in postmenopausal women]. |
2016 |
Rev Med Chil |
pmid:28394953
|
Raza S et al. |
27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells. |
2016 |
Med. Oncol. |
pmid:26732475
|
Hashimoto Y et al. |
27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells. |
2016 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:27036870
|
Nguyen VT et al. |
Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. |
2015 |
Nat Commun |
pmid:26610607
|
Yin K et al. |
Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine. |
2015 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:26381871
|
Mignarri A et al. |
Treatment of SPG5 with cholesterol-lowering drugs. |
2015 |
J. Neurol. |
pmid:26566916
|
Raza S et al. |
The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. |
2015 |
Mol. Cell. Biochem. |
pmid:26350565
|
Javitt NB |
Breast cancer and (25R)-26-hydroxycholesterol. |
2015 |
Steroids |
pmid:26299212
|
Kim SM et al. |
27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide. |
2015 |
Biochim. Biophys. Acta |
pmid:25497142
|
Kim SM et al. |
27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-κB and CD88. |
2015 |
Biochem. Biophys. Res. Commun. |
pmid:26086093
|
Zhang DD et al. |
27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain. |
2015 |
Neuroscience |
pmid:25987203
|
Marwarha G and Ghribi O |
Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap? |
2015 |
Exp. Gerontol. |
pmid:25261765
|
Ma WW et al. |
The oxysterol 27-hydroxycholesterol increases oxidative stress and regulate Nrf2 signaling pathway in astrocyte cells. |
2015 |
Neurochem. Res. |
pmid:25630716
|
Heverin M et al. |
27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice. |
2015 |
Behav. Brain Res. |
pmid:25453744
|
Hendrikx T et al. |
Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice. |
2015 |
J. Hepatol. |
pmid:25281859
|
Wicher G and Norlin M |
Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis. |
2015 |
J. Steroid Biochem. Mol. Biol. |
pmid:25263657
|
Gargiulo S et al. |
Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability. |
2015 |
Aging Cell |
pmid:25757594
|
Virginio VW et al. |
Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. |
2015 |
Free Radic. Res. |
pmid:25465091
|
Novakova L et al. |
Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. |
2015 |
J. Neurol. Sci. |
pmid:26342940
|
Nelson ER et al. |
Cholesterol and breast cancer pathophysiology. |
2014 |
Trends Endocrinol. Metab. |
pmid:25458418
|
McDonnell DP et al. |
The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer. |
2014 |
Climacteric |
pmid:25320023
|
Vurusaner B et al. |
Survival signaling elicited by 27-hydroxycholesterol through the combined modulation of cellular redox state and ERK/Akt phosphorylation. |
2014 |
Free Radic. Biol. Med. |
pmid:25110320
|
Wardell SE et al. |
From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs). |
2014 |
Steroids |
pmid:25084324
|
McDonnell DP et al. |
Obesity, cholesterol metabolism, and breast cancer pathogenesis. |
2014 |
Cancer Res. |
pmid:25060521
|
Dias IH et al. |
Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation. |
2014 |
Free Radic. Biol. Med. |
pmid:25048970
|
Ma D et al. |
ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels. |
2014 |
Biochimie |
pmid:24793484
|
Umetani M et al. |
The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. |
2014 |
Cell Metab. |
pmid:24954418
|
Nunes VS et al. |
Increased 27-hydroxycholesterol plasma level in men with low high density lipoprotein-cholesterol may circumvent their reduced cell cholesterol efflux rate. |
2014 |
Clin. Chim. Acta |
pmid:24657483
|
Mignarri A et al. |
Hereditary spastic paraplegia type 5: a potentially treatable disorder of cholesterol metabolism. |
2014 |
J. Neurol. |
pmid:24509641
|
Fu H et al. |
β-Cryptoxanthin uptake in THP-1 macrophages upregulates the CYP27A1 signaling pathway. |
2014 |
Mol Nutr Food Res |
pmid:24123714
|
Gosselet F et al. |
Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24275140
|
van de Kraats C et al. |
Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis. |
2014 |
Mult. Scler. |
pmid:23959711
|
Kim SM et al. |
27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes. |
2014 |
Toxicol. Appl. Pharmacol. |
pmid:24370436
|
Testa G et al. |
Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. |
2014 |
PLoS ONE |
pmid:24802026
|
Civra A et al. |
Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol. |
2014 |
Sci Rep |
pmid:25501851
|
Li J et al. |
De novo synthesis of steroids and oxysterols in adipocytes. |
2014 |
J. Biol. Chem. |
pmid:24280213
|
|
Cholesterol metabolite linked to breast cancer. |
2014 |
Cancer Discov |
pmid:24596219
|
Bandaru VV and Haughey NJ |
Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. |
2014 |
BMC Neurosci |
pmid:25539717
|
Gamba P et al. |
Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. |
2014 |
Aging Cell |
pmid:24612036
|
Warner M and Gustafsson JA |
On estrogen, cholesterol metabolism, and breast cancer. |
2014 |
N. Engl. J. Med. |
pmid:24499217
|
Baila-Rueda L et al. |
Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24406166
|
Saint-Pol J et al. |
Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. |
2013 |
Brain Res. |
pmid:23603412
|
Ali Z et al. |
On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice. |
2013 |
J. Lipid Res. |
pmid:23284090
|
Dasari B et al. |
Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. |
2013 |
Curr. Eye Res. |
pmid:23841471
|
Leoni V and Caccia C |
Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. |
2013 |
Biochem. Pharmacol. |
pmid:23541982
|
Manna PR et al. |
Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein. |
2013 |
J. Biol. Chem. |
pmid:23362264
|
Nunes VS et al. |
Plasma 27-hydroxycholesterol/cholesterol ratio is increased in low high density lipoprotein-cholesterol healthy subjects. |
2013 |
Clin. Biochem. |
pmid:23850851
|
Freemantle E et al. |
Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. |
2013 |
Int. J. Neuropsychopharmacol. |
pmid:23369504
|
Kim SM et al. |
27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:23246833
|
Baker ME |
What are the physiological estrogens? |
2013 |
Steroids |
pmid:23313336
|
Bieghs V et al. |
The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. |
2013 |
Gastroenterology |
pmid:23041327
|
Marwarha G et al. |
Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells. |
2013 |
PLoS ONE |
pmid:23951005
|
Kaiser J |
Cancer. Cholesterol forges link between obesity and breast cancer. |
2013 |
Science |
pmid:24288308
|
Nelson ER et al. |
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. |
2013 |
Science |
pmid:24288332
|
Wu Q et al. |
27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. |
2013 |
Cell Rep |
pmid:24210818
|
Kim SM et al. |
27-Hydroxycholesterol induces recruitment of monocytic cells by enhancing CCL2 production. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:24269812
|
Acimovic J et al. |
Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. |
2013 |
PLoS ONE |
pmid:23844150
|
Ragot K et al. |
Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. |
2013 |
Biochem. Pharmacol. |
pmid:23473804
|
Son Y et al. |
Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:23876312
|
Björkhem I et al. |
Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. |
2013 |
Neurosci. Lett. |
pmid:24035896
|
Cruz P et al. |
27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells. |
2012 |
Oncol. Rep. |
pmid:22710948
|
Popp J et al. |
Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease. |
2012 |
J. Neurochem. |
pmid:22845771
|
Mateos L et al. |
side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. |
2012 |
Neurodegener Dis |
pmid:22236548
|
Emanuelsson I and Norlin M |
Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells. |
2012 |
Neurosci. Lett. |
pmid:22884615
|
Bertolotti M et al. |
Increased appearance rate of 27-hydroxycholesterol in vivo in hypercholesterolemia: a possible compensatory mechanism. |
2012 |
Nutr Metab Cardiovasc Dis |
pmid:21546230
|