27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Martin KO et al. | Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes. | 1993 | J. Lipid Res. | pmid:8496664 |
| Petrack B and Latario BJ | Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol. | 1993 | J. Lipid Res. | pmid:8496670 |
| Meaney S et al. | Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid. | 2007 | J. Lipid Res. | pmid:17251592 |
| Heverin M et al. | Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain. | 2005 | J. Lipid Res. | pmid:15741649 |
| Lee C et al. | Bile acid synthesis: 7 alpha-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway. | 1996 | J. Lipid Res. | pmid:8808770 |
| Li T et al. | PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. | 2007 | J. Lipid Res. | pmid:17088262 |
| Leoni V et al. | Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers. | 2003 | J. Lipid Res. | pmid:12562838 |
| Axelson M et al. | Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. | 1995 | J. Lipid Res. | pmid:7751816 |
| Burkard I et al. | Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry. | 2004 | J. Lipid Res. | pmid:14729854 |
| Shafaati M et al. | Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation. | 2011 | J. Lipid Res. | pmid:21335619 |
| Reiss AB et al. | Immune complexes and IFN-gamma decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages. | 2001 | J. Lipid Res. | pmid:11714861 |
| Heverin M et al. | Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. | 2004 | J. Lipid Res. | pmid:14523054 |
| Lange Y et al. | Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol. | 2009 | J. Lipid Res. | pmid:19401598 |
| Reiss AB et al. | Sterol 27-hydroxylase: high levels of activity in vascular endothelium. | 1994 | J. Lipid Res. | pmid:8077842 |
| Schüle R et al. | Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. | 2010 | J. Lipid Res. | pmid:19812052 |
| Meaney S et al. | Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis: increased levels in patients with pulmonary alveolar proteinosis. | 2004 | J. Lipid Res. | pmid:15466366 |
| Honda A et al. | Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS. | 2009 | J. Lipid Res. | pmid:18815436 |
| Li X et al. | Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes. | 2007 | J. Lipid Res. | pmid:17890683 |
| Mistry HD et al. | Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia. | 2017 | J. Lipid Res. | pmid:28396342 |
| Duane WC and Javitt NB | 27-hydroxycholesterol: production rates in normal human subjects. | 1999 | J. Lipid Res. | pmid:10393204 |