|
|
|
|
pmid:
|
Luomala M et al. |
Osteopontin levels are associated with cholesterol synthesis markers in mildly hypercholesterolaemic patients. |
2007 |
Acta Cardiol |
pmid:17536607
|
Björkhem I et al. |
Oxysterols and Alzheimer's disease. |
2006 |
Acta Neurol. Scand., Suppl.c |
pmid:16866910
|
Lütjohann D et al. |
Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol. |
2001 |
Acta Paediatr. |
pmid:11440099
|
Gamba P et al. |
Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. |
2011 |
Aging Cell |
pmid:21272192
|
Gargiulo S et al. |
Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability. |
2015 |
Aging Cell |
pmid:25757594
|
Gamba P et al. |
Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. |
2014 |
Aging Cell |
pmid:24612036
|
Klass DM et al. |
Biliary lipids, cholesterol and bile synthesis: different adaptive mechanisms to dietary cholesterol in lean and obese subjects. |
2006 |
Aliment. Pharmacol. Ther. |
pmid:16573792
|
Escher G et al. |
Role of CYP27A1 in progesterone metabolism in vitro and in vivo. |
2009 |
Am. J. Physiol. Endocrinol. Metab. |
pmid:19671838
|
de Vogel-van den Bosch HM et al. |
A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. |
2008 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:18356535
|
Hall E et al. |
Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis. |
2001 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
pmid:11408283
|
Hashimoto Y et al. |
27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells. |
2016 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:27036870
|
Wu Y et al. |
Liver X receptor as a drug target for the treatment of breast cancer. |
2016 |
Anticancer Drugs |
pmid:26872310
|
Guéguen Y et al. |
Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat. |
2006 |
Arch. Toxicol. |
pmid:16231126
|
Yin K et al. |
Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine. |
2015 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:26381871
|
Westman J et al. |
Sterol 27-hydroxylase- and apoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages: evidence for an inverse relation between the two mechanisms. |
1998 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:9555860
|
Corsini A et al. |
Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes. |
1995 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:7749852
|
Kushwaha RS et al. |
Effect of dietary cholesterol and fat on the expression of hepatic sterol 27-hydroxylase and other hepatic cholesterol-responsive genes in baboons (Papio species). |
1995 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:7670955
|
von Bahr S et al. |
Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1). |
2002 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:12117727
|
Karuna R et al. |
Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. |
2011 |
Atherosclerosis |
pmid:21130455
|
Yasunobu Y et al. |
Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols. |
2001 |
Atherosclerosis |
pmid:11254916
|
Weingärtner O et al. |
An alternative pathway of reverse cholesterol transport: the oxysterol 27-hydroxycholesterol. |
2010 |
Atherosclerosis |
pmid:19801147
|
Burkard I et al. |
Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. |
2007 |
Atherosclerosis |
pmid:17107679
|
Chen LD et al. |
Effect of naturally reduced ovarian function on plasma lipoprotein and 27-hydroxycholesterol levels in baboons (Papio sp.). |
1998 |
Atherosclerosis |
pmid:9544735
|
Morello F et al. |
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. |
2009 |
Atherosclerosis |
pmid:19426978
|
Shanahan CM et al. |
A potential role for sterol 27-hydroxylase in atherogenesis. |
2001 |
Atherosclerosis |
pmid:11166758
|
Heverin M et al. |
27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice. |
2015 |
Behav. Brain Res. |
pmid:25453744
|
Kim SM et al. |
27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-κB and CD88. |
2015 |
Biochem. Biophys. Res. Commun. |
pmid:26086093
|
Gosselet F et al. |
Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24275140
|
Kim SM et al. |
27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:23246833
|
Kim SM et al. |
27-Hydroxycholesterol induces recruitment of monocytic cells by enhancing CCL2 production. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:24269812
|
Baila-Rueda L et al. |
Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24406166
|
Son Y et al. |
Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells. |
2013 |
Biochem. Biophys. Res. Commun. |
pmid:23876312
|
Ma LM et al. |
27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells. |
2016 |
Biochem. Biophys. Res. Commun. |
pmid:27751849
|
Kim BY et al. |
Diclofenac inhibits 27-hydroxycholesterol-induced inflammation. |
2016 |
Biochem. Biophys. Res. Commun. |
pmid:27576203
|
Zhang J et al. |
Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. |
1997 |
Biochem. J. |
pmid:9078259
|
Summerfield JA et al. |
Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man. |
1976 |
Biochem. J. |
pmid:938463
|
Leoni V and Caccia C |
Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. |
2013 |
Biochem. Pharmacol. |
pmid:23541982
|
Ragot K et al. |
Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. |
2013 |
Biochem. Pharmacol. |
pmid:23473804
|
Zhang J et al. |
Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase. |
1997 |
Biochim. Biophys. Acta |
pmid:9059514
|
Kim SM et al. |
27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide. |
2015 |
Biochim. Biophys. Acta |
pmid:25497142
|
Javitt NB |
Biologic role(s) of the 25(R),26-hydroxycholesterol metabolic pathway. |
2000 |
Biochim. Biophys. Acta |
pmid:11111083
|
Zhang J et al. |
7 alpha-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts. |
1995 |
Biochim. Biophys. Acta |
pmid:7786899
|
Crow JA et al. |
Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. |
2010 |
Biochim. Biophys. Acta |
pmid:19761868
|
Sauter G et al. |
Formation of cholic acid and chenodeoxycholic acid from 7 alpha-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes. |
1996 |
Biochim. Biophys. Acta |
pmid:8608157
|
Hall EA et al. |
Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells. |
2005 |
Biochim. Biophys. Acta |
pmid:15863358
|
Hansson M et al. |
Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages. |
2003 |
Biochim. Biophys. Acta |
pmid:12581873
|
Russell DW |
Oxysterol biosynthetic enzymes. |
2000 |
Biochim. Biophys. Acta |
pmid:11111082
|
Björkhem I et al. |
7 alpha-hydroxylation of 27-hydroxycholesterol in human liver microsomes. |
1992 |
Biochim. Biophys. Acta |
pmid:1390879
|
Babiker A and Diczfalusy U |
Transport of side-chain oxidized oxysterols in the human circulation. |
1998 |
Biochim. Biophys. Acta |
pmid:9630709
|
Hasan SQ and Kushwaha RS |
Differences in 27-hydroxycholesterol concentrations in plasma and liver of baboons with high and low responses to dietary cholesterol and fat. |
1993 |
Biochim. Biophys. Acta |
pmid:8399364
|
Lund E et al. |
24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. |
1993 |
Biochim. Biophys. Acta |
pmid:8443234
|
Crisby M et al. |
Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques. |
1997 |
Biochim. Biophys. Acta |
pmid:9059518
|
Norlin M and Wikvall K |
Biochemical characterization of the 7alpha-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes. |
1998 |
Biochim. Biophys. Acta |
pmid:9487148
|
Ma D et al. |
ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels. |
2014 |
Biochimie |
pmid:24793484
|
Marengo B et al. |
Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages. |
|
Biofactors |
pmid:26669587
|
Bogan RL et al. |
Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. |
2012 |
Biol. Reprod. |
pmid:22156476
|
Zhou Q and Kummerow FA |
Effect of 27-hydroxycholesterol on cellular sphingomyelin synthesis and Ca++ content in cultured smooth muscle cells. |
1997 |
Biomed. Environ. Sci. |
pmid:9448918
|
Bandaru VV and Haughey NJ |
Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. |
2014 |
BMC Neurosci |
pmid:25539717
|
Dasari B et al. |
The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. |
2010 |
BMC Ophthalmol |
pmid:20836858
|
Winkler BS et al. |
Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies. |
2017 |
BMC Pregnancy Childbirth |
pmid:28376740
|
Schöls L et al. |
Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. |
2017 |
Brain |
pmid:29126212
|
Weiner MF et al. |
Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. |
2008 |
Brain Inj |
pmid:18568715
|
Mateos L et al. |
Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro. |
2009 |
Brain Pathol. |
pmid:18503570
|
Saint-Pol J et al. |
Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. |
2013 |
Brain Res. |
pmid:23603412
|
Zhang J et al. |
7 Alpha-hydroxylation of 27-hydroxycholesterol in rat brain microsomes. |
1995 |
C. R. Acad. Sci. III, Sci. Vie |
pmid:7788503
|
Souidi M et al. |
Effects of dietary 27-hydroxycholesterol on cholesterol metabolism and bile acid biosynthesis in the hamster. |
2003 |
Can. J. Physiol. Pharmacol. |
pmid:14614521
|
|
Cholesterol metabolite linked to breast cancer. |
2014 |
Cancer Discov |
pmid:24596219
|
McDonnell DP et al. |
Obesity, cholesterol metabolism, and breast cancer pathogenesis. |
2014 |
Cancer Res. |
pmid:25060521
|
Alfaqih MA et al. |
CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. |
2017 |
Cancer Res. |
pmid:28130224
|
Taylor JM et al. |
Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI. |
2010 |
Cardiovasc. Res. |
pmid:20083572
|
Umetani M et al. |
The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. |
2014 |
Cell Metab. |
pmid:24954418
|
Chen W et al. |
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. |
2007 |
Cell Metab. |
pmid:17189208
|
Wu Q et al. |
27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. |
2013 |
Cell Rep |
pmid:24210818
|
Marwarha G et al. |
Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. |
2012 |
Cell. Signal. |
pmid:21983012
|
Marwarha G et al. |
27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. |
2017 |
Chem. Phys. Lipids |
pmid:28583434
|
Kikuchi T et al. |
Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis. |
2012 |
Chest |
pmid:22281802
|
Blom T et al. |
FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. |
2010 |
Circ. Res. |
pmid:20056921
|
Rossouw JE et al. |
Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy. |
2012 |
Circulation |
pmid:22932256
|
McDonnell DP et al. |
The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer. |
2014 |
Climacteric |
pmid:25320023
|
Nunes VS et al. |
Plasma 27-hydroxycholesterol/cholesterol ratio is increased in low high density lipoprotein-cholesterol healthy subjects. |
2013 |
Clin. Biochem. |
pmid:23850851
|
Leoni V et al. |
Diagnostic use of cerebral and extracerebral oxysterols. |
2004 |
Clin. Chem. Lab. Med. |
pmid:15061359
|
Nunes VS et al. |
Increased 27-hydroxycholesterol plasma level in men with low high density lipoprotein-cholesterol may circumvent their reduced cell cholesterol efflux rate. |
2014 |
Clin. Chim. Acta |
pmid:24657483
|
Kimura A et al. |
Neonatal cholestasis with increased 3β-monohydroxy-Δⵠbile acids in serum and urine: not necessarily primary oxysterol 7α hydroxylase deficiency. |
2012 |
Clin. Chim. Acta |
pmid:22652365
|
Crosignani A et al. |
Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis. |
2008 |
Clin. Chim. Acta |
pmid:18538136
|
Del Puppo M et al. |
A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis. |
2005 |
Clin. Chim. Acta |
pmid:15820474
|
Crosignani A et al. |
Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease. |
2007 |
Clin. Chim. Acta |
pmid:17482152
|
Dasari B et al. |
Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. |
2013 |
Curr. Eye Res. |
pmid:23841471
|
Jeitner TM et al. |
Oxysterol derivatives of cholesterol in neurodegenerative disorders. |
2011 |
Curr. Med. Chem. |
pmid:21428891
|
Kimbung S et al. |
Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. |
2017 |
Endocr. Relat. Cancer |
pmid:28442559
|
DuSell CD et al. |
The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. |
2010 |
Endocrinology |
pmid:20501668
|
Nelson ER et al. |
The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. |
2011 |
Endocrinology |
pmid:21933863
|
Shen Z et al. |
27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3. |
2017 |
Environ. Toxicol. Pharmacol. |
pmid:28257824
|
Zhang J et al. |
7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes. |
1997 |
Eur. J. Biochem. |
pmid:9249018
|
Rosklint T et al. |
Oxysterols induce interleukin-1beta production in human macrophages. |
2002 |
Eur. J. Clin. Invest. |
pmid:11851725
|
Thelen KM et al. |
Effect of pravastatin on plasma sterols and oxysterols in men. |
2006 |
Eur. J. Clin. Pharmacol. |
pmid:16385401
|
Tsankova V et al. |
Peripheral benzodiazepine receptor ligands in rat liver mitochondria: effect on 27-hydroxylation of cholesterol. |
1996 |
Eur. J. Pharmacol. |
pmid:8901023
|
Marwarha G and Ghribi O |
Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap? |
2015 |
Exp. Gerontol. |
pmid:25261765
|
Javitt NB |
Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. |
1994 |
FASEB J. |
pmid:8001744
|
Bellosta S et al. |
27-Hydroxycholesterol modulation of low density lipoprotein metabolism in cultured human hepatic and extrahepatic cells. |
1993 |
FEBS Lett. |
pmid:8405424
|