27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Schöls L et al. | Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. | 2017 | Brain | pmid:29126212 |
| Cagno V et al. | Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2017 | Redox Biol | pmid:28359048 |
| Cardenia V et al. | Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27084531 |
| Baek AE et al. | The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. | 2017 | Nat Commun | pmid:29021522 |
| He S and Nelson ER | 27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator. | 2017 | Maturitas | pmid:28923174 |
| Kimbung S et al. | Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. | 2017 | Endocr. Relat. Cancer | pmid:28442559 |
| Mistry HD et al. | Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia. | 2017 | J. Lipid Res. | pmid:28396342 |
| An Y et al. | 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells. | 2017 | Neurotoxicology | pmid:28167099 |
| Winkler BS et al. | Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies. | 2017 | BMC Pregnancy Childbirth | pmid:28376740 |
| Brooks SW et al. | A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus. | 2017 | J. Alzheimers Dis. | pmid:27911307 |
| Kim BY et al. | Dexamethasone inhibits activation of monocytes/macrophages in a milieu rich in 27-oxygenated cholesterol. | 2017 | PLoS ONE | pmid:29236764 |
| Marwarha G et al. | 27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. | 2017 | Chem. Phys. Lipids | pmid:28583434 |
| Kim BY et al. | 27-Hydroxycholesterol upregulates the production of heat shock protein 60 of monocytic cells. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:28549691 |
| Shen Z et al. | 27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3. | 2017 | Environ. Toxicol. Pharmacol. | pmid:28257824 |
| Alfaqih MA et al. | CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. | 2017 | Cancer Res. | pmid:28130224 |
| Roberg-Larsen H et al. | Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26877254 |
| Oguro H et al. | 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. | 2017 | J. Clin. Invest. | pmid:28783041 |
| Heverin M et al. | On the regulatory importance of 27-hydroxycholesterol in mouse liver. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26851362 |
| Ismail MA et al. | 27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation. | 2017 | J. Exp. Med. | pmid:28213512 |
| Vurusaner B et al. | Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells. | 2016 | Free Radic. Biol. Med. | pmid:26689473 |
| Vini R et al. | Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27-hydroxycholesterol. | 2016 | IUBMB Life | pmid:26756990 |
| Ehrhardt M et al. | Expression of human CYP27A1 in B. megaterium for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol. | 2016 | J. Biotechnol. | pmid:26638999 |
| Umetani M | Re-adopting classical nuclear receptors by cholesterol metabolites. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:26563834 |
| Nelson ER | Detection of Endogenous Selective Estrogen Receptor Modulators such as 27-Hydroxycholesterol. | 2016 | Methods Mol. Biol. | pmid:26585155 |
| Mignarri A et al. | Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. | 2016 | J. Inherit. Metab. Dis. | pmid:26153518 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Liu Q et al. | Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. | 2016 | Lipids Health Dis | pmid:27724967 |
| Wang HL et al. | Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. | 2016 | J. Alzheimers Dis. | pmid:26836015 |
| Zhu D et al. | The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells. | 2016 | Toxicol. Lett. | pmid:27856279 |
| Perone Y and Magnani L | Going off the grid: ERα breast cancer beyond estradiol. | 2016 | J. Mol. Endocrinol. | pmid:27151575 |
| Ma LM et al. | 27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751849 |
| Wang H et al. | The cytotoxicity of 27-hydroxycholesterol in co-cultured SH-SY5Y cells and C6 cells. | 2016 | Neurosci. Lett. | pmid:27592060 |
| Kim BY et al. | Diclofenac inhibits 27-hydroxycholesterol-induced inflammation. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27576203 |
| Wu Y et al. | Liver X receptor as a drug target for the treatment of breast cancer. | 2016 | Anticancer Drugs | pmid:26872310 |
| Rocha G et al. | [27- Hydroxycholesterol reverses estradiol induced inhibition of platelet aggregation in postmenopausal women]. | 2016 | Rev Med Chil | pmid:28394953 |
| Raza S et al. | 27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells. | 2016 | Med. Oncol. | pmid:26732475 |
| Hashimoto Y et al. | 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27036870 |
| Nguyen VT et al. | Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. | 2015 | Nat Commun | pmid:26610607 |
| Yin K et al. | Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine. | 2015 | Arterioscler. Thromb. Vasc. Biol. | pmid:26381871 |
| Mignarri A et al. | Treatment of SPG5 with cholesterol-lowering drugs. | 2015 | J. Neurol. | pmid:26566916 |
| Raza S et al. | The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. | 2015 | Mol. Cell. Biochem. | pmid:26350565 |
| Javitt NB | Breast cancer and (25R)-26-hydroxycholesterol. | 2015 | Steroids | pmid:26299212 |
| Kim SM et al. | 27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide. | 2015 | Biochim. Biophys. Acta | pmid:25497142 |
| Kim SM et al. | 27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-κB and CD88. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086093 |
| Zhang DD et al. | 27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain. | 2015 | Neuroscience | pmid:25987203 |
| Marwarha G and Ghribi O | Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap? | 2015 | Exp. Gerontol. | pmid:25261765 |
| Ma WW et al. | The oxysterol 27-hydroxycholesterol increases oxidative stress and regulate Nrf2 signaling pathway in astrocyte cells. | 2015 | Neurochem. Res. | pmid:25630716 |
| Heverin M et al. | 27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice. | 2015 | Behav. Brain Res. | pmid:25453744 |
| Hendrikx T et al. | Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice. | 2015 | J. Hepatol. | pmid:25281859 |
| Wicher G and Norlin M | Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25263657 |
| Gargiulo S et al. | Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability. | 2015 | Aging Cell | pmid:25757594 |
| Virginio VW et al. | Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. | 2015 | Free Radic. Res. | pmid:25465091 |
| Novakova L et al. | Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. | 2015 | J. Neurol. Sci. | pmid:26342940 |
| Nelson ER et al. | Cholesterol and breast cancer pathophysiology. | 2014 | Trends Endocrinol. Metab. | pmid:25458418 |
| McDonnell DP et al. | The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer. | 2014 | Climacteric | pmid:25320023 |
| Vurusaner B et al. | Survival signaling elicited by 27-hydroxycholesterol through the combined modulation of cellular redox state and ERK/Akt phosphorylation. | 2014 | Free Radic. Biol. Med. | pmid:25110320 |
| Wardell SE et al. | From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs). | 2014 | Steroids | pmid:25084324 |
| McDonnell DP et al. | Obesity, cholesterol metabolism, and breast cancer pathogenesis. | 2014 | Cancer Res. | pmid:25060521 |
| Dias IH et al. | Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation. | 2014 | Free Radic. Biol. Med. | pmid:25048970 |
| Ma D et al. | ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels. | 2014 | Biochimie | pmid:24793484 |
| Umetani M et al. | The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. | 2014 | Cell Metab. | pmid:24954418 |
| Nunes VS et al. | Increased 27-hydroxycholesterol plasma level in men with low high density lipoprotein-cholesterol may circumvent their reduced cell cholesterol efflux rate. | 2014 | Clin. Chim. Acta | pmid:24657483 |
| Mignarri A et al. | Hereditary spastic paraplegia type 5: a potentially treatable disorder of cholesterol metabolism. | 2014 | J. Neurol. | pmid:24509641 |
| Fu H et al. | β-Cryptoxanthin uptake in THP-1 macrophages upregulates the CYP27A1 signaling pathway. | 2014 | Mol Nutr Food Res | pmid:24123714 |
| Gosselet F et al. | Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24275140 |
| van de Kraats C et al. | Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis. | 2014 | Mult. Scler. | pmid:23959711 |
| Kim SM et al. | 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24370436 |
| Testa G et al. | Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. | 2014 | PLoS ONE | pmid:24802026 |
| Civra A et al. | Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Sci Rep | pmid:25501851 |
| Li J et al. | De novo synthesis of steroids and oxysterols in adipocytes. | 2014 | J. Biol. Chem. | pmid:24280213 |
| Cholesterol metabolite linked to breast cancer. | 2014 | Cancer Discov | pmid:24596219 | |
| Bandaru VV and Haughey NJ | Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. | 2014 | BMC Neurosci | pmid:25539717 |
| Gamba P et al. | Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine. | 2014 | Aging Cell | pmid:24612036 |
| Warner M and Gustafsson JA | On estrogen, cholesterol metabolism, and breast cancer. | 2014 | N. Engl. J. Med. | pmid:24499217 |
| Baila-Rueda L et al. | Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24406166 |
| Saint-Pol J et al. | Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. | 2013 | Brain Res. | pmid:23603412 |
| Ali Z et al. | On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice. | 2013 | J. Lipid Res. | pmid:23284090 |
| Dasari B et al. | Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. | 2013 | Curr. Eye Res. | pmid:23841471 |
| Leoni V and Caccia C | Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. | 2013 | Biochem. Pharmacol. | pmid:23541982 |
| Manna PR et al. | Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein. | 2013 | J. Biol. Chem. | pmid:23362264 |
| Nunes VS et al. | Plasma 27-hydroxycholesterol/cholesterol ratio is increased in low high density lipoprotein-cholesterol healthy subjects. | 2013 | Clin. Biochem. | pmid:23850851 |
| Freemantle E et al. | Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. | 2013 | Int. J. Neuropsychopharmacol. | pmid:23369504 |
| Kim SM et al. | 27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23246833 |
| Baker ME | What are the physiological estrogens? | 2013 | Steroids | pmid:23313336 |
| Bieghs V et al. | The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. | 2013 | Gastroenterology | pmid:23041327 |
| Marwarha G et al. | Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells. | 2013 | PLoS ONE | pmid:23951005 |
| Kaiser J | Cancer. Cholesterol forges link between obesity and breast cancer. | 2013 | Science | pmid:24288308 |
| Nelson ER et al. | 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. | 2013 | Science | pmid:24288332 |
| Wu Q et al. | 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. | 2013 | Cell Rep | pmid:24210818 |
| Kim SM et al. | 27-Hydroxycholesterol induces recruitment of monocytic cells by enhancing CCL2 production. | 2013 | Biochem. Biophys. Res. Commun. | pmid:24269812 |
| Acimovic J et al. | Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. | 2013 | PLoS ONE | pmid:23844150 |
| Ragot K et al. | Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. | 2013 | Biochem. Pharmacol. | pmid:23473804 |
| Son Y et al. | Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23876312 |
| Björkhem I et al. | Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. | 2013 | Neurosci. Lett. | pmid:24035896 |
| Marwarha G et al. | Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. | 2012 | Cell. Signal. | pmid:21983012 |
| Kikuchi T et al. | Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis. | 2012 | Chest | pmid:22281802 |
| Rossouw JE et al. | Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy. | 2012 | Circulation | pmid:22932256 |
| Kimura A et al. | Neonatal cholestasis with increased 3β-monohydroxy-Δⵠbile acids in serum and urine: not necessarily primary oxysterol 7α hydroxylase deficiency. | 2012 | Clin. Chim. Acta | pmid:22652365 |
| Fakheri RJ and Javitt NB | 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols. | 2012 | Steroids | pmid:22366074 |