27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim SM et al. | 27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide. | 2015 | Biochim. Biophys. Acta | pmid:25497142 |
| Javitt NB | Biologic role(s) of the 25(R),26-hydroxycholesterol metabolic pathway. | 2000 | Biochim. Biophys. Acta | pmid:11111083 |
| Hansson M et al. | Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages. | 2003 | Biochim. Biophys. Acta | pmid:12581873 |
| Crisby M et al. | Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques. | 1997 | Biochim. Biophys. Acta | pmid:9059518 |
| Ma D et al. | ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels. | 2014 | Biochimie | pmid:24793484 |
| Marengo B et al. | Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages. | Biofactors | pmid:26669587 | |
| Bogan RL et al. | Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. | 2012 | Biol. Reprod. | pmid:22156476 |
| Zhou Q and Kummerow FA | Effect of 27-hydroxycholesterol on cellular sphingomyelin synthesis and Ca++ content in cultured smooth muscle cells. | 1997 | Biomed. Environ. Sci. | pmid:9448918 |
| Bandaru VV and Haughey NJ | Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. | 2014 | BMC Neurosci | pmid:25539717 |
| Dasari B et al. | The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells. | 2010 | BMC Ophthalmol | pmid:20836858 |
| Winkler BS et al. | Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies. | 2017 | BMC Pregnancy Childbirth | pmid:28376740 |
| Schöls L et al. | Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. | 2017 | Brain | pmid:29126212 |
| Weiner MF et al. | Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury. | 2008 | Brain Inj | pmid:18568715 |
| Mateos L et al. | Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro. | 2009 | Brain Pathol. | pmid:18503570 |
| Saint-Pol J et al. | Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. | 2013 | Brain Res. | pmid:23603412 |
| Zhang J et al. | 7 Alpha-hydroxylation of 27-hydroxycholesterol in rat brain microsomes. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:7788503 |
| Souidi M et al. | Effects of dietary 27-hydroxycholesterol on cholesterol metabolism and bile acid biosynthesis in the hamster. | 2003 | Can. J. Physiol. Pharmacol. | pmid:14614521 |
| Cholesterol metabolite linked to breast cancer. | 2014 | Cancer Discov | pmid:24596219 | |
| McDonnell DP et al. | Obesity, cholesterol metabolism, and breast cancer pathogenesis. | 2014 | Cancer Res. | pmid:25060521 |
| Alfaqih MA et al. | CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. | 2017 | Cancer Res. | pmid:28130224 |
| Taylor JM et al. | Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI. | 2010 | Cardiovasc. Res. | pmid:20083572 |
| Umetani M et al. | The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. | 2014 | Cell Metab. | pmid:24954418 |
| Chen W et al. | Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. | 2007 | Cell Metab. | pmid:17189208 |
| Wu Q et al. | 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. | 2013 | Cell Rep | pmid:24210818 |
| Marwarha G et al. | Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. | 2012 | Cell. Signal. | pmid:21983012 |
| Marwarha G et al. | 27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. | 2017 | Chem. Phys. Lipids | pmid:28583434 |
| Kikuchi T et al. | Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis. | 2012 | Chest | pmid:22281802 |
| Blom T et al. | FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. | 2010 | Circ. Res. | pmid:20056921 |
| Rossouw JE et al. | Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy. | 2012 | Circulation | pmid:22932256 |
| McDonnell DP et al. | The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer. | 2014 | Climacteric | pmid:25320023 |
| Nunes VS et al. | Plasma 27-hydroxycholesterol/cholesterol ratio is increased in low high density lipoprotein-cholesterol healthy subjects. | 2013 | Clin. Biochem. | pmid:23850851 |
| Leoni V et al. | Diagnostic use of cerebral and extracerebral oxysterols. | 2004 | Clin. Chem. Lab. Med. | pmid:15061359 |
| Nunes VS et al. | Increased 27-hydroxycholesterol plasma level in men with low high density lipoprotein-cholesterol may circumvent their reduced cell cholesterol efflux rate. | 2014 | Clin. Chim. Acta | pmid:24657483 |
| Kimura A et al. | Neonatal cholestasis with increased 3β-monohydroxy-Δⵠbile acids in serum and urine: not necessarily primary oxysterol 7α hydroxylase deficiency. | 2012 | Clin. Chim. Acta | pmid:22652365 |
| Crosignani A et al. | Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis. | 2008 | Clin. Chim. Acta | pmid:18538136 |
| Del Puppo M et al. | A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis. | 2005 | Clin. Chim. Acta | pmid:15820474 |
| Crosignani A et al. | Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease. | 2007 | Clin. Chim. Acta | pmid:17482152 |
| Dasari B et al. | Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. | 2013 | Curr. Eye Res. | pmid:23841471 |
| Jeitner TM et al. | Oxysterol derivatives of cholesterol in neurodegenerative disorders. | 2011 | Curr. Med. Chem. | pmid:21428891 |
| Kimbung S et al. | Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. | 2017 | Endocr. Relat. Cancer | pmid:28442559 |
| DuSell CD et al. | The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. | 2010 | Endocrinology | pmid:20501668 |
| Nelson ER et al. | The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors. | 2011 | Endocrinology | pmid:21933863 |
| Shen Z et al. | 27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3. | 2017 | Environ. Toxicol. Pharmacol. | pmid:28257824 |
| Zhang J et al. | 7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes. | 1997 | Eur. J. Biochem. | pmid:9249018 |
| Rosklint T et al. | Oxysterols induce interleukin-1beta production in human macrophages. | 2002 | Eur. J. Clin. Invest. | pmid:11851725 |
| Thelen KM et al. | Effect of pravastatin on plasma sterols and oxysterols in men. | 2006 | Eur. J. Clin. Pharmacol. | pmid:16385401 |
| Tsankova V et al. | Peripheral benzodiazepine receptor ligands in rat liver mitochondria: effect on 27-hydroxylation of cholesterol. | 1996 | Eur. J. Pharmacol. | pmid:8901023 |
| Marwarha G and Ghribi O | Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap? | 2015 | Exp. Gerontol. | pmid:25261765 |
| Javitt NB | Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. | 1994 | FASEB J. | pmid:8001744 |
| Bellosta S et al. | 27-Hydroxycholesterol modulation of low density lipoprotein metabolism in cultured human hepatic and extrahepatic cells. | 1993 | FEBS Lett. | pmid:8405424 |