27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mistry HD et al. | Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia. | 2017 | J. Lipid Res. | pmid:28396342 |
| Rocha G et al. | [27- Hydroxycholesterol reverses estradiol induced inhibition of platelet aggregation in postmenopausal women]. | 2016 | Rev Med Chil | pmid:28394953 |
| Winkler BS et al. | Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies. | 2017 | BMC Pregnancy Childbirth | pmid:28376740 |
| Cagno V et al. | Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2017 | Redox Biol | pmid:28359048 |
| Shen Z et al. | 27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3. | 2017 | Environ. Toxicol. Pharmacol. | pmid:28257824 |
| Ismail MA et al. | 27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation. | 2017 | J. Exp. Med. | pmid:28213512 |
| An Y et al. | 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells. | 2017 | Neurotoxicology | pmid:28167099 |
| Alfaqih MA et al. | CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. | 2017 | Cancer Res. | pmid:28130224 |
| Brooks SW et al. | A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus. | 2017 | J. Alzheimers Dis. | pmid:27911307 |
| Zhu D et al. | The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells. | 2016 | Toxicol. Lett. | pmid:27856279 |
| Ma LM et al. | 27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751849 |
| Liu Q et al. | Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. | 2016 | Lipids Health Dis | pmid:27724967 |
| Wang H et al. | The cytotoxicity of 27-hydroxycholesterol in co-cultured SH-SY5Y cells and C6 cells. | 2016 | Neurosci. Lett. | pmid:27592060 |
| Kim BY et al. | Diclofenac inhibits 27-hydroxycholesterol-induced inflammation. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27576203 |
| Perone Y and Magnani L | Going off the grid: ERα breast cancer beyond estradiol. | 2016 | J. Mol. Endocrinol. | pmid:27151575 |
| Cardenia V et al. | Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27084531 |
| Stellaard F et al. | The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27060336 |
| Hashimoto Y et al. | 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27036870 |
| Roberg-Larsen H et al. | Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26877254 |
| Wu Y et al. | Liver X receptor as a drug target for the treatment of breast cancer. | 2016 | Anticancer Drugs | pmid:26872310 |
| Heverin M et al. | On the regulatory importance of 27-hydroxycholesterol in mouse liver. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26851362 |
| Wang HL et al. | Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. | 2016 | J. Alzheimers Dis. | pmid:26836015 |
| Vini R et al. | Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27-hydroxycholesterol. | 2016 | IUBMB Life | pmid:26756990 |
| Raza S et al. | 27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells. | 2016 | Med. Oncol. | pmid:26732475 |
| Vurusaner B et al. | Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells. | 2016 | Free Radic. Biol. Med. | pmid:26689473 |
| Marengo B et al. | Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages. | Biofactors | pmid:26669587 | |
| Ehrhardt M et al. | Expression of human CYP27A1 in B. megaterium for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol. | 2016 | J. Biotechnol. | pmid:26638999 |
| Nguyen VT et al. | Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. | 2015 | Nat Commun | pmid:26610607 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Nelson ER | Detection of Endogenous Selective Estrogen Receptor Modulators such as 27-Hydroxycholesterol. | 2016 | Methods Mol. Biol. | pmid:26585155 |
| Mignarri A et al. | Treatment of SPG5 with cholesterol-lowering drugs. | 2015 | J. Neurol. | pmid:26566916 |
| Umetani M | Re-adopting classical nuclear receptors by cholesterol metabolites. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:26563834 |
| Yin K et al. | Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine. | 2015 | Arterioscler. Thromb. Vasc. Biol. | pmid:26381871 |
| Raza S et al. | The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. | 2015 | Mol. Cell. Biochem. | pmid:26350565 |
| Novakova L et al. | Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. | 2015 | J. Neurol. Sci. | pmid:26342940 |
| Javitt NB | Breast cancer and (25R)-26-hydroxycholesterol. | 2015 | Steroids | pmid:26299212 |
| Mignarri A et al. | Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. | 2016 | J. Inherit. Metab. Dis. | pmid:26153518 |
| Kim SM et al. | 27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-κB and CD88. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086093 |
| Zhang DD et al. | 27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain. | 2015 | Neuroscience | pmid:25987203 |
| Gargiulo S et al. | Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability. | 2015 | Aging Cell | pmid:25757594 |
| Ma WW et al. | The oxysterol 27-hydroxycholesterol increases oxidative stress and regulate Nrf2 signaling pathway in astrocyte cells. | 2015 | Neurochem. Res. | pmid:25630716 |
| Bandaru VV and Haughey NJ | Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. | 2014 | BMC Neurosci | pmid:25539717 |
| Civra A et al. | Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Sci Rep | pmid:25501851 |
| Kim SM et al. | 27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide. | 2015 | Biochim. Biophys. Acta | pmid:25497142 |
| Virginio VW et al. | Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. | 2015 | Free Radic. Res. | pmid:25465091 |
| Nelson ER et al. | Cholesterol and breast cancer pathophysiology. | 2014 | Trends Endocrinol. Metab. | pmid:25458418 |
| Heverin M et al. | 27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice. | 2015 | Behav. Brain Res. | pmid:25453744 |
| McDonnell DP et al. | The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer. | 2014 | Climacteric | pmid:25320023 |
| Hendrikx T et al. | Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice. | 2015 | J. Hepatol. | pmid:25281859 |
| Wicher G and Norlin M | Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25263657 |