27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Karuna R et al. | Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism. | 2011 | Atherosclerosis | pmid:21130455 |
| Yasunobu Y et al. | Coronary atherosclerosis and oxidative stress as reflected by autoantibodies against oxidized low-density lipoprotein and oxysterols. | 2001 | Atherosclerosis | pmid:11254916 |
| Weingärtner O et al. | An alternative pathway of reverse cholesterol transport: the oxysterol 27-hydroxycholesterol. | 2010 | Atherosclerosis | pmid:19801147 |
| Chen LD et al. | Effect of naturally reduced ovarian function on plasma lipoprotein and 27-hydroxycholesterol levels in baboons (Papio sp.). | 1998 | Atherosclerosis | pmid:9544735 |
| Morello F et al. | LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. | 2009 | Atherosclerosis | pmid:19426978 |
| Shanahan CM et al. | A potential role for sterol 27-hydroxylase in atherogenesis. | 2001 | Atherosclerosis | pmid:11166758 |
| Heverin M et al. | 27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice. | 2015 | Behav. Brain Res. | pmid:25453744 |
| Gosselet F et al. | Effects of oxysterols on the blood-brain barrier: implications for Alzheimer's disease. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24275140 |
| Baila-Rueda L et al. | Bile acid synthesis precursors in familial combined hyperlipidemia: the oxysterols 24S-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24406166 |
| Ma LM et al. | 27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751849 |