27-hydroxy-cholesterol(25R)

27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.

Cross Reference

Introduction

To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 27-hydroxy-cholesterol(25R)?

27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Alcoholism D000437 27 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with 27-hydroxy-cholesterol(25R)

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 27-hydroxy-cholesterol(25R)?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with 27-hydroxy-cholesterol(25R)?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 27-hydroxy-cholesterol(25R)?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with 27-hydroxy-cholesterol(25R)?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 27-hydroxy-cholesterol(25R)?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 27-hydroxy-cholesterol(25R)

Download all related citations
Per page 10 20 50 100 | Total 269
Authors Title Published Journal PubMed Link
Roberg-Larsen H et al. Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes. 2017 J. Steroid Biochem. Mol. Biol. pmid:26877254
Hashimoto Y et al. 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells. 2016 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:27036870
Stellaard F et al. The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. 2017 J. Steroid Biochem. Mol. Biol. pmid:27060336
Cardenia V et al. Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. 2017 J. Steroid Biochem. Mol. Biol. pmid:27084531
Perone Y and Magnani L Going off the grid: ERα breast cancer beyond estradiol. 2016 J. Mol. Endocrinol. pmid:27151575
Kim BY et al. Diclofenac inhibits 27-hydroxycholesterol-induced inflammation. 2016 Biochem. Biophys. Res. Commun. pmid:27576203
Wang H et al. The cytotoxicity of 27-hydroxycholesterol in co-cultured SH-SY5Y cells and C6 cells. 2016 Neurosci. Lett. pmid:27592060
Liu Q et al. Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. 2016 Lipids Health Dis pmid:27724967
Ma LM et al. 27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells. 2016 Biochem. Biophys. Res. Commun. pmid:27751849
Zhu D et al. The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells. 2016 Toxicol. Lett. pmid:27856279
Brooks SW et al. A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus. 2017 J. Alzheimers Dis. pmid:27911307
Alfaqih MA et al. CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. 2017 Cancer Res. pmid:28130224
An Y et al. 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells. 2017 Neurotoxicology pmid:28167099
Ismail MA et al. 27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation. 2017 J. Exp. Med. pmid:28213512
Shen Z et al. 27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3. 2017 Environ. Toxicol. Pharmacol. pmid:28257824
Cagno V et al. Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. 2017 Redox Biol pmid:28359048
Winkler BS et al. Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies. 2017 BMC Pregnancy Childbirth pmid:28376740
Rocha G et al. [27- Hydroxycholesterol reverses estradiol induced inhibition of platelet aggregation in postmenopausal women]. 2016 Rev Med Chil pmid:28394953
Mistry HD et al. Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia. 2017 J. Lipid Res. pmid:28396342
Kimbung S et al. Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. 2017 Endocr. Relat. Cancer pmid:28442559
Kim BY et al. 27-Hydroxycholesterol upregulates the production of heat shock protein 60 of monocytic cells. 2017 J. Steroid Biochem. Mol. Biol. pmid:28549691
Marwarha G et al. 27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. 2017 Chem. Phys. Lipids pmid:28583434
Oguro H et al. 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. 2017 J. Clin. Invest. pmid:28783041
He S and Nelson ER 27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator. 2017 Maturitas pmid:28923174
Baek AE et al. The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. 2017 Nat Commun pmid:29021522
Schöls L et al. Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. 2017 Brain pmid:29126212
Kim BY et al. Dexamethasone inhibits activation of monocytes/macrophages in a milieu rich in 27-oxygenated cholesterol. 2017 PLoS ONE pmid:29236764
Rajagopalon I et al. 26-Hydroxycholesterol disulfate: metabolism and excretion in the normal neonate. 1986 J. Steroid Biochem. pmid:3795956
Kushwaha RS et al. Effect of dietary cholesterol and fat on the expression of hepatic sterol 27-hydroxylase and other hepatic cholesterol-responsive genes in baboons (Papio species). 1995 Arterioscler. Thromb. Vasc. Biol. pmid:7670955
Szedlacsek SE et al. Esterification of oxysterols by human plasma lecithin-cholesterol acyltransferase. 1995 J. Biol. Chem. pmid:7744831
Corsini A et al. Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes. 1995 Arterioscler. Thromb. Vasc. Biol. pmid:7749852
Axelson M et al. Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. 1995 J. Lipid Res. pmid:7751816
Zhang J et al. 7 alpha-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts. 1995 Biochim. Biophys. Acta pmid:7786899
Zhang J et al. 7 Alpha-hydroxylation of 27-hydroxycholesterol in rat brain microsomes. 1995 C. R. Acad. Sci. III, Sci. Vie pmid:7788503
Axelson M and Larsson O Low density lipoprotein (LDL) cholesterol is converted to 27-hydroxycholesterol in human fibroblasts. Evidence that 27-hydroxycholesterol can be an important intracellular mediator between LDL and the suppression of cholesterol production. 1995 J. Biol. Chem. pmid:7797494
Javitt NB Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. 1994 FASEB J. pmid:8001744
Shoda J et al. Novel sterol 7 alpha-hydroxylase(s), microsomal 27-hydroxycholesterol 7 alpha-hydroxylase, in cholesterol gallstone disease and its etiological significance. 1994 J. Gastroenterol. pmid:8012516
Reiss AB et al. Sterol 27-hydroxylase: high levels of activity in vascular endothelium. 1994 J. Lipid Res. pmid:8077842
Hasan SQ and Kushwaha RS Differences in 27-hydroxycholesterol concentrations in plasma and liver of baboons with high and low responses to dietary cholesterol and fat. 1993 Biochim. Biophys. Acta pmid:8399364
Bellosta S et al. 27-Hydroxycholesterol modulation of low density lipoprotein metabolism in cultured human hepatic and extrahepatic cells. 1993 FEBS Lett. pmid:8405424
Lund E et al. 24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. 1993 Biochim. Biophys. Acta pmid:8443234
Shoda J et al. Formation of 7 alpha- and 7 beta-hydroxylated bile acid precursors from 27-hydroxycholesterol in human liver microsomes and mitochondria. 1993 Hepatology pmid:8444412
Shoda J et al. Synthesis of potential C27-intermediates in bile acid biosynthesis and their deuterium-labeled analogs. 1993 Steroids pmid:8475516
Martin KO et al. Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes. 1993 J. Lipid Res. pmid:8496664
Petrack B and Latario BJ Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol. 1993 J. Lipid Res. pmid:8496670
Sauter G et al. Formation of cholic acid and chenodeoxycholic acid from 7 alpha-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes. 1996 Biochim. Biophys. Acta pmid:8608157
Lee C et al. Bile acid synthesis: 7 alpha-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway. 1996 J. Lipid Res. pmid:8808770
Winegar DA et al. Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells. 1996 J. Lipid Res. pmid:8820113
Tsankova V et al. Peripheral benzodiazepine receptor ligands in rat liver mitochondria: effect on 27-hydroxylation of cholesterol. 1996 Eur. J. Pharmacol. pmid:8901023
Lehmann JM et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. 1997 J. Biol. Chem. pmid:9013544
Zhang J et al. Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase. 1997 Biochim. Biophys. Acta pmid:9059514
Crisby M et al. Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques. 1997 Biochim. Biophys. Acta pmid:9059518
Zhang J et al. Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. 1997 Biochem. J. pmid:9078259
Lala DS et al. Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. 1997 Proc. Natl. Acad. Sci. U.S.A. pmid:9144161
Martin KO et al. 7 alpha-hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis. 1997 J. Lipid Res. pmid:9186922
Reiss AB et al. Sterol 27-hydroxylase: expression in human arterial endothelium. 1997 J. Lipid Res. pmid:9215552
Zhang J et al. 7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes. 1997 Eur. J. Biochem. pmid:9249018
Summerfield JA et al. Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man. 1976 Biochem. J. pmid:938463
Zhou Q and Kummerow FA Effect of 27-hydroxycholesterol on cellular sphingomyelin synthesis and Ca++ content in cultured smooth muscle cells. 1997 Biomed. Environ. Sci. pmid:9448918
Norlin M and Wikvall K Biochemical characterization of the 7alpha-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes. 1998 Biochim. Biophys. Acta pmid:9487148
Chen LD et al. Effect of naturally reduced ovarian function on plasma lipoprotein and 27-hydroxycholesterol levels in baboons (Papio sp.). 1998 Atherosclerosis pmid:9544735
Westman J et al. Sterol 27-hydroxylase- and apoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages: evidence for an inverse relation between the two mechanisms. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9555860
Babiker A and Diczfalusy U Transport of side-chain oxidized oxysterols in the human circulation. 1998 Biochim. Biophys. Acta pmid:9630709
Pikuleva IA et al. Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways. 1998 J. Biol. Chem. pmid:9660774
Javitt NB Cholic acid synthesis from 27-hydroxycholesterol in humans. 1998 Gastroenterology pmid:9758543
Xiu R et al. [Elimination of cholesterol in human endothelial cells]. 1997 Zhonghua Yi Xue Za Zhi pmid:9772537
Arnon R et al. Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis. 1998 Gastroenterology pmid:9797378
Christenson LK et al. Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions. 1998 J. Biol. Chem. pmid:9804848
Del Puppo M et al. Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway. 1998 J. Lipid Res. pmid:9831637