27-hydroxy-cholesterol(25R)

27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.

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Introduction

To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 27-hydroxy-cholesterol(25R)?

27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)

MeSH term MeSH ID Detail
Hypercholesterolemia D006937 91 associated lipids
Alzheimer Disease D000544 76 associated lipids
Alcoholism D000437 27 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Xanthomatosis, Cerebrotendinous D019294 14 associated lipids
Total 6

PubChem Associated disorders and diseases

What pathways are associated with 27-hydroxy-cholesterol(25R)

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 27-hydroxy-cholesterol(25R)?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with 27-hydroxy-cholesterol(25R)?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with 27-hydroxy-cholesterol(25R)?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with 27-hydroxy-cholesterol(25R)?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 27-hydroxy-cholesterol(25R)?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with 27-hydroxy-cholesterol(25R)

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Authors Title Published Journal PubMed Link
Saint-Pol J et al. Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells. 2013 Brain Res. pmid:23603412
Ali Z et al. On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1(-/-) mice. 2013 J. Lipid Res. pmid:23284090
Dasari B et al. Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells. 2013 Curr. Eye Res. pmid:23841471
Leoni V and Caccia C Potential diagnostic applications of side chain oxysterols analysis in plasma and cerebrospinal fluid. 2013 Biochem. Pharmacol. pmid:23541982
Manna PR et al. Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein. 2013 J. Biol. Chem. pmid:23362264
Freemantle E et al. Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. 2013 Int. J. Neuropsychopharmacol. pmid:23369504
Bieghs V et al. The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. 2013 Gastroenterology pmid:23041327
Marwarha G et al. Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells. 2013 PLoS ONE pmid:23951005
Kaiser J Cancer. Cholesterol forges link between obesity and breast cancer. 2013 Science pmid:24288308
Nelson ER et al. 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. 2013 Science pmid:24288332
Wu Q et al. 27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth. 2013 Cell Rep pmid:24210818
Kim SM et al. 27-Hydroxycholesterol induces recruitment of monocytic cells by enhancing CCL2 production. 2013 Biochem. Biophys. Res. Commun. pmid:24269812
Acimovic J et al. Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. 2013 PLoS ONE pmid:23844150
Ragot K et al. Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes. 2013 Biochem. Pharmacol. pmid:23473804
Son Y et al. Oxysterols induce transition of monocytic cells to phenotypically mature dendritic cell-like cells. 2013 Biochem. Biophys. Res. Commun. pmid:23876312
Marwarha G et al. Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol. 2012 Cell. Signal. pmid:21983012
Kikuchi T et al. Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis. 2012 Chest pmid:22281802
Rossouw JE et al. Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy. 2012 Circulation pmid:22932256
Kimura A et al. Neonatal cholestasis with increased 3β-monohydroxy-Δ⁵ bile acids in serum and urine: not necessarily primary oxysterol 7α hydroxylase deficiency. 2012 Clin. Chim. Acta pmid:22652365
Fakheri RJ and Javitt NB 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols. 2012 Steroids pmid:22366074