27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Stellaard F et al. | The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27060336 |
| Roberg-Larsen H et al. | Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26877254 |
| Heverin M et al. | On the regulatory importance of 27-hydroxycholesterol in mouse liver. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26851362 |
| Zhou Q et al. | 27-Hydroxycholesterol inhibits neutral sphingomyelinase in cultured human endothelial cells. | 2004 | Life Sci. | pmid:15261762 |
| Kummerow FA et al. | 27-Hydroxycholesterol causes remodeling in endothelial cell membrane lipid composition comparable to remodeling in the failed vein grafts of CABG patients. | 2006 | Life Sci. | pmid:16154158 |
| Liu Q et al. | Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. | 2016 | Lipids Health Dis | pmid:27724967 |
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| Raza S et al. | 27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells. | 2016 | Med. Oncol. | pmid:26732475 |
| Honda A et al. | Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits. | 2004 | Metab. Clin. Exp. | pmid:14681840 |
| Nelson ER | Detection of Endogenous Selective Estrogen Receptor Modulators such as 27-Hydroxycholesterol. | 2016 | Methods Mol. Biol. | pmid:26585155 |
| Prasanthi JR et al. | Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. | 2009 | Mol Neurodegener | pmid:19126211 |
| Fu H et al. | β-Cryptoxanthin uptake in THP-1 macrophages upregulates the CYP27A1 signaling pathway. | 2014 | Mol Nutr Food Res | pmid:24123714 |
| Olkkonen VM and Hynynen R | Interactions of oxysterols with membranes and proteins. | 2009 | Mol. Aspects Med. | pmid:19248802 |
| Raza S et al. | The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. | 2015 | Mol. Cell. Biochem. | pmid:26350565 |
| Szanto A et al. | Transcriptional regulation of human CYP27 integrates retinoid, peroxisome proliferator-activated receptor, and liver X receptor signaling in macrophages. | 2004 | Mol. Cell. Biol. | pmid:15340076 |
| DuSell CD et al. | 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. | 2008 | Mol. Endocrinol. | pmid:17872378 |
| van de Kraats C et al. | Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis. | 2014 | Mult. Scler. | pmid:23959711 |
| Warner M and Gustafsson JA | On estrogen, cholesterol metabolism, and breast cancer. | 2014 | N. Engl. J. Med. | pmid:24499217 |
| Nguyen VT et al. | Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. | 2015 | Nat Commun | pmid:26610607 |
| Baek AE et al. | The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. | 2017 | Nat Commun | pmid:29021522 |
| Umetani M et al. | 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. | 2007 | Nat. Med. | pmid:17873880 |
| Liu C et al. | Oxysterols direct B-cell migration through EBI2. | 2011 | Nature | pmid:21796211 |
| Koschack J et al. | Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals. | 2009 | Neurobiol. Aging | pmid:18061309 |
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| van den Kommer TN et al. | Total cholesterol and oxysterols: early markers for cognitive decline in elderly? | 2009 | Neurobiol. Aging | pmid:17888546 |
| Sharma S et al. | Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling. | 2008 | Neurobiol. Dis. | pmid:18775495 |
| Ma WW et al. | The oxysterol 27-hydroxycholesterol increases oxidative stress and regulate Nrf2 signaling pathway in astrocyte cells. | 2015 | Neurochem. Res. | pmid:25630716 |
| Mateos L et al. | side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons. | 2012 | Neurodegener Dis | pmid:22236548 |
| Cheng D et al. | Regulation of alpha-synuclein expression by liver X receptor ligands in vitro. | 2008 | Neuroreport | pmid:18841091 |
| Kölsch H et al. | Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients. | 2004 | Neurosci. Lett. | pmid:15364416 |
| Solomon A et al. | Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease. | 2009 | Neurosci. Lett. | pmid:19560513 |
| Emanuelsson I and Norlin M | Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells. | 2012 | Neurosci. Lett. | pmid:22884615 |
| Björkhem I et al. | Oxysterols and Parkinson's disease: evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease. | 2013 | Neurosci. Lett. | pmid:24035896 |
| Wang H et al. | The cytotoxicity of 27-hydroxycholesterol in co-cultured SH-SY5Y cells and C6 cells. | 2016 | Neurosci. Lett. | pmid:27592060 |
| Zhang DD et al. | 27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain. | 2015 | Neuroscience | pmid:25987203 |
| Gilardi F et al. | Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling. | 2009 | Neuroscience | pmid:19665519 |
| An Y et al. | 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells. | 2017 | Neurotoxicology | pmid:28167099 |
| Bertolotti M et al. | Increased appearance rate of 27-hydroxycholesterol in vivo in hypercholesterolemia: a possible compensatory mechanism. | 2012 | Nutr Metab Cardiovasc Dis | pmid:21546230 |
| Torres CG et al. | 27-hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype. | 2011 | Oncol. Rep. | pmid:21567091 |
| Cruz P et al. | 27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells. | 2012 | Oncol. Rep. | pmid:22710948 |
| Gong H and Williams JR | Synthesis of the aglycone of the shark repellent pavoninin-4 using remote functionalization. | 2006 | Org. Lett. | pmid:16706499 |
| Prasanthi JR et al. | Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus. | 2011 | PLoS ONE | pmid:22046282 |
| Testa G et al. | Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols. | 2014 | PLoS ONE | pmid:24802026 |
| Marwarha G et al. | Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells. | 2013 | PLoS ONE | pmid:23951005 |
| Acimovic J et al. | Sulphatation does not appear to be a protective mechanism to prevent oxysterol accumulation in humans and mice. | 2013 | PLoS ONE | pmid:23844150 |
| Kim BY et al. | Dexamethasone inhibits activation of monocytes/macrophages in a milieu rich in 27-oxygenated cholesterol. | 2017 | PLoS ONE | pmid:29236764 |
| Lala DS et al. | Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9144161 |
| Cagno V et al. | Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2017 | Redox Biol | pmid:28359048 |
| Rocha G et al. | [27- Hydroxycholesterol reverses estradiol induced inhibition of platelet aggregation in postmenopausal women]. | 2016 | Rev Med Chil | pmid:28394953 |
| Babiker A et al. | Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid. | 2005 | Scand. J. Clin. Lab. Invest. | pmid:16081359 |