27-hydroxy-cholesterol(25r) is a lipid of Sterol Lipids (ST) class. 27-hydroxy-cholesterol(25r) is associated with abnormalities such as Consumption-archaic term for TB and Kozlowski Celermajer Tink syndrome. The involved functions are known as CYP27A1activity, mRNA Expression, Anabolism, Steroid biosynthesis and Metabolic Process, Cellular. 27-hydroxy-cholesterol(25r) often locates in Body tissue, soluble, Mitochondria and Inner mitochondrial membrane. The associated genes with 27-hydroxy-cholesterol(25R) are ABRA gene, IGKV1-16 gene, HSD3B1 gene, CYP21A2 gene and TSPO gene. The related lipids are Steroids and cholesterol analog.
To understand associated biological information of 27-hydroxy-cholesterol(25R), we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
27-hydroxy-cholesterol(25R) is suspected in Kozlowski Celermajer Tink syndrome and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 27-hydroxy-cholesterol(25R)
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Alcoholism | D000437 | 27 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Xanthomatosis, Cerebrotendinous | D019294 | 14 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Del Puppo M et al. | Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway. | 1998 | J. Lipid Res. | pmid:9831637 |
| Christenson LK et al. | Oxysterol regulation of steroidogenic acute regulatory protein gene expression. Structural specificity and transcriptional and posttranscriptional actions. | 1998 | J. Biol. Chem. | pmid:9804848 |
| Arnon R et al. | Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis. | 1998 | Gastroenterology | pmid:9797378 |
| Xiu R et al. | [Elimination of cholesterol in human endothelial cells]. | 1997 | Zhonghua Yi Xue Za Zhi | pmid:9772537 |
| Javitt NB | Cholic acid synthesis from 27-hydroxycholesterol in humans. | 1998 | Gastroenterology | pmid:9758543 |
| Pikuleva IA et al. | Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways. | 1998 | J. Biol. Chem. | pmid:9660774 |
| Babiker A and Diczfalusy U | Transport of side-chain oxidized oxysterols in the human circulation. | 1998 | Biochim. Biophys. Acta | pmid:9630709 |
| Westman J et al. | Sterol 27-hydroxylase- and apoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages: evidence for an inverse relation between the two mechanisms. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555860 |
| Chen LD et al. | Effect of naturally reduced ovarian function on plasma lipoprotein and 27-hydroxycholesterol levels in baboons (Papio sp.). | 1998 | Atherosclerosis | pmid:9544735 |
| Norlin M and Wikvall K | Biochemical characterization of the 7alpha-hydroxylase activities towards 27-hydroxycholesterol and dehydroepiandrosterone in pig liver microsomes. | 1998 | Biochim. Biophys. Acta | pmid:9487148 |
| Zhou Q and Kummerow FA | Effect of 27-hydroxycholesterol on cellular sphingomyelin synthesis and Ca++ content in cultured smooth muscle cells. | 1997 | Biomed. Environ. Sci. | pmid:9448918 |
| Summerfield JA et al. | Identification of bile acids in the serum and urine in cholestasis. Evidence for 6alpha-hydroxylation of bile acids in man. | 1976 | Biochem. J. | pmid:938463 |
| Zhang J et al. | 7alpha-Hydroxylation and 3-dehydrogenation abolish the ability of 25-hydroxycholesterol and 27-hydroxycholesterol to induce apoptosis in thymocytes. | 1997 | Eur. J. Biochem. | pmid:9249018 |
| Reiss AB et al. | Sterol 27-hydroxylase: expression in human arterial endothelium. | 1997 | J. Lipid Res. | pmid:9215552 |
| Martin KO et al. | 7 alpha-hydroxylation of 27-hydroxycholesterol: biologic role in the regulation of cholesterol synthesis. | 1997 | J. Lipid Res. | pmid:9186922 |
| Lala DS et al. | Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9144161 |
| Zhang J et al. | Metabolism of 27-, 25- and 24-hydroxycholesterol in rat glial cells and neurons. | 1997 | Biochem. J. | pmid:9078259 |
| Crisby M et al. | Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques. | 1997 | Biochim. Biophys. Acta | pmid:9059518 |
| Zhang J et al. | Studies on the relationships between 7 alpha-hydroxylation and the ability of 25- and 27-hydroxycholesterol to suppress the activity of HMG-CoA reductase. | 1997 | Biochim. Biophys. Acta | pmid:9059514 |
| Lehmann JM et al. | Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. | 1997 | J. Biol. Chem. | pmid:9013544 |
| Tsankova V et al. | Peripheral benzodiazepine receptor ligands in rat liver mitochondria: effect on 27-hydroxylation of cholesterol. | 1996 | Eur. J. Pharmacol. | pmid:8901023 |
| Winegar DA et al. | Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells. | 1996 | J. Lipid Res. | pmid:8820113 |
| Lee C et al. | Bile acid synthesis: 7 alpha-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway. | 1996 | J. Lipid Res. | pmid:8808770 |
| Sauter G et al. | Formation of cholic acid and chenodeoxycholic acid from 7 alpha-hydroxycholesterol and 27-hydroxycholesterol by primary cultures of human hepatocytes. | 1996 | Biochim. Biophys. Acta | pmid:8608157 |
| Petrack B and Latario BJ | Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol. | 1993 | J. Lipid Res. | pmid:8496670 |
| Martin KO et al. | Cholesterol and 27-hydroxycholesterol 7 alpha-hydroxylation: evidence for two different enzymes. | 1993 | J. Lipid Res. | pmid:8496664 |
| Shoda J et al. | Synthesis of potential C27-intermediates in bile acid biosynthesis and their deuterium-labeled analogs. | 1993 | Steroids | pmid:8475516 |
| Shoda J et al. | Formation of 7 alpha- and 7 beta-hydroxylated bile acid precursors from 27-hydroxycholesterol in human liver microsomes and mitochondria. | 1993 | Hepatology | pmid:8444412 |
| Lund E et al. | 24-, 25- and 27-hydroxylation of cholesterol by a purified preparation of 27-hydroxylase from pig liver. | 1993 | Biochim. Biophys. Acta | pmid:8443234 |
| Bellosta S et al. | 27-Hydroxycholesterol modulation of low density lipoprotein metabolism in cultured human hepatic and extrahepatic cells. | 1993 | FEBS Lett. | pmid:8405424 |
| Hasan SQ and Kushwaha RS | Differences in 27-hydroxycholesterol concentrations in plasma and liver of baboons with high and low responses to dietary cholesterol and fat. | 1993 | Biochim. Biophys. Acta | pmid:8399364 |
| Reiss AB et al. | Sterol 27-hydroxylase: high levels of activity in vascular endothelium. | 1994 | J. Lipid Res. | pmid:8077842 |
| Shoda J et al. | Novel sterol 7 alpha-hydroxylase(s), microsomal 27-hydroxycholesterol 7 alpha-hydroxylase, in cholesterol gallstone disease and its etiological significance. | 1994 | J. Gastroenterol. | pmid:8012516 |
| Javitt NB | Bile acid synthesis from cholesterol: regulatory and auxiliary pathways. | 1994 | FASEB J. | pmid:8001744 |
| Axelson M and Larsson O | Low density lipoprotein (LDL) cholesterol is converted to 27-hydroxycholesterol in human fibroblasts. Evidence that 27-hydroxycholesterol can be an important intracellular mediator between LDL and the suppression of cholesterol production. | 1995 | J. Biol. Chem. | pmid:7797494 |
| Zhang J et al. | 7 Alpha-hydroxylation of 27-hydroxycholesterol in rat brain microsomes. | 1995 | C. R. Acad. Sci. III, Sci. Vie | pmid:7788503 |
| Zhang J et al. | 7 alpha-Hydroxylation of 25-hydroxycholesterol and 27-hydroxycholesterol in human fibroblasts. | 1995 | Biochim. Biophys. Acta | pmid:7786899 |
| Axelson M et al. | Structural specificity in the suppression of HMG-CoA reductase in human fibroblasts by intermediates in bile acid biosynthesis. | 1995 | J. Lipid Res. | pmid:7751816 |
| Corsini A et al. | Effects of 26-aminocholesterol, 27-hydroxycholesterol, and 25-hydroxycholesterol on proliferation and cholesterol homeostasis in arterial myocytes. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7749852 |
| Szedlacsek SE et al. | Esterification of oxysterols by human plasma lecithin-cholesterol acyltransferase. | 1995 | J. Biol. Chem. | pmid:7744831 |
| Kushwaha RS et al. | Effect of dietary cholesterol and fat on the expression of hepatic sterol 27-hydroxylase and other hepatic cholesterol-responsive genes in baboons (Papio species). | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7670955 |
| Rajagopalon I et al. | 26-Hydroxycholesterol disulfate: metabolism and excretion in the normal neonate. | 1986 | J. Steroid Biochem. | pmid:3795956 |
| Kim BY et al. | Dexamethasone inhibits activation of monocytes/macrophages in a milieu rich in 27-oxygenated cholesterol. | 2017 | PLoS ONE | pmid:29236764 |
| Schöls L et al. | Hereditary spastic paraplegia type 5: natural history, biomarkers and a randomized controlled trial. | 2017 | Brain | pmid:29126212 |
| Baek AE et al. | The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. | 2017 | Nat Commun | pmid:29021522 |
| He S and Nelson ER | 27-Hydroxycholesterol, an endogenous selective estrogen receptor modulator. | 2017 | Maturitas | pmid:28923174 |
| Oguro H et al. | 27-Hydroxycholesterol induces hematopoietic stem cell mobilization and extramedullary hematopoiesis during pregnancy. | 2017 | J. Clin. Invest. | pmid:28783041 |
| Marwarha G et al. | 27-hydroxycholesterol: A novel player in molecular carcinogenesis of breast and prostate cancer. | 2017 | Chem. Phys. Lipids | pmid:28583434 |
| Kim BY et al. | 27-Hydroxycholesterol upregulates the production of heat shock protein 60 of monocytic cells. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:28549691 |
| Kimbung S et al. | Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. | 2017 | Endocr. Relat. Cancer | pmid:28442559 |
| Mistry HD et al. | Increased maternal and fetal cholesterol efflux capacity and placental CYP27A1 expression in preeclampsia. | 2017 | J. Lipid Res. | pmid:28396342 |
| Rocha G et al. | [27- Hydroxycholesterol reverses estradiol induced inhibition of platelet aggregation in postmenopausal women]. | 2016 | Rev Med Chil | pmid:28394953 |
| Winkler BS et al. | Maternal 27-hydroxycholesterol concentrations during the course of pregnancy and in pregnancy pathologies. | 2017 | BMC Pregnancy Childbirth | pmid:28376740 |
| Cagno V et al. | Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2017 | Redox Biol | pmid:28359048 |
| Shen Z et al. | 27-Hydroxycholesterol induces invasion and migration of breast cancer cells by increasing MMP9 and generating EMT through activation of STAT-3. | 2017 | Environ. Toxicol. Pharmacol. | pmid:28257824 |
| Ismail MA et al. | 27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation. | 2017 | J. Exp. Med. | pmid:28213512 |
| An Y et al. | 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells. | 2017 | Neurotoxicology | pmid:28167099 |
| Alfaqih MA et al. | CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. | 2017 | Cancer Res. | pmid:28130224 |
| Brooks SW et al. | A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus. | 2017 | J. Alzheimers Dis. | pmid:27911307 |
| Zhu D et al. | The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells. | 2016 | Toxicol. Lett. | pmid:27856279 |
| Ma LM et al. | 27-Hydroxycholesterol increases Myc protein stability via suppressing PP2A, SCP1 and FBW7 transcription in MCF-7 breast cancer cells. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27751849 |
| Liu Q et al. | Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study. | 2016 | Lipids Health Dis | pmid:27724967 |
| Wang H et al. | The cytotoxicity of 27-hydroxycholesterol in co-cultured SH-SY5Y cells and C6 cells. | 2016 | Neurosci. Lett. | pmid:27592060 |
| Kim BY et al. | Diclofenac inhibits 27-hydroxycholesterol-induced inflammation. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27576203 |
| Perone Y and Magnani L | Going off the grid: ERα breast cancer beyond estradiol. | 2016 | J. Mol. Endocrinol. | pmid:27151575 |
| Cardenia V et al. | Effect of broccoli extract enriched diet on liver cholesterol oxidation in rats subjected to exhaustive exercise. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27084531 |
| Stellaard F et al. | The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27060336 |
| Hashimoto Y et al. | 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27036870 |
| Roberg-Larsen H et al. | Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26877254 |
| Wu Y et al. | Liver X receptor as a drug target for the treatment of breast cancer. | 2016 | Anticancer Drugs | pmid:26872310 |
| Heverin M et al. | On the regulatory importance of 27-hydroxycholesterol in mouse liver. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26851362 |
| Wang HL et al. | Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis. | 2016 | J. Alzheimers Dis. | pmid:26836015 |
| Vini R et al. | Evidence of pomegranate methanolic extract in antagonizing the endogenous SERM, 27-hydroxycholesterol. | 2016 | IUBMB Life | pmid:26756990 |
| Raza S et al. | 27-Hydroxycholesterol stimulates cell proliferation and resistance to docetaxel-induced apoptosis in prostate epithelial cells. | 2016 | Med. Oncol. | pmid:26732475 |
| Vurusaner B et al. | Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells. | 2016 | Free Radic. Biol. Med. | pmid:26689473 |
| Marengo B et al. | Oxysterol mixture and, in particular, 27-hydroxycholesterol drive M2 polarization of human macrophages. | Biofactors | pmid:26669587 | |
| Ehrhardt M et al. | Expression of human CYP27A1 in B. megaterium for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol. | 2016 | J. Biotechnol. | pmid:26638999 |
| Nguyen VT et al. | Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. | 2015 | Nat Commun | pmid:26610607 |
| Pataj Z et al. | Quantification of oxysterols in human plasma and red blood cells by liquid chromatography high-resolution tandem mass spectrometry. | 2016 | J Chromatogr A | pmid:26607314 |
| Nelson ER | Detection of Endogenous Selective Estrogen Receptor Modulators such as 27-Hydroxycholesterol. | 2016 | Methods Mol. Biol. | pmid:26585155 |
| Mignarri A et al. | Treatment of SPG5 with cholesterol-lowering drugs. | 2015 | J. Neurol. | pmid:26566916 |
| Umetani M | Re-adopting classical nuclear receptors by cholesterol metabolites. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:26563834 |
| Yin K et al. | Vitamin D Protects Against Atherosclerosis via Regulation of Cholesterol Efflux and Macrophage Polarization in Hypercholesterolemic Swine. | 2015 | Arterioscler. Thromb. Vasc. Biol. | pmid:26381871 |
| Raza S et al. | The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. | 2015 | Mol. Cell. Biochem. | pmid:26350565 |
| Novakova L et al. | Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis. | 2015 | J. Neurol. Sci. | pmid:26342940 |
| Javitt NB | Breast cancer and (25R)-26-hydroxycholesterol. | 2015 | Steroids | pmid:26299212 |
| Mignarri A et al. | Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. | 2016 | J. Inherit. Metab. Dis. | pmid:26153518 |
| Kim SM et al. | 27-Oxygenated cholesterol induces expression of CXCL8 in macrophages via NF-κB and CD88. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26086093 |
| Zhang DD et al. | 27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain. | 2015 | Neuroscience | pmid:25987203 |
| Gargiulo S et al. | Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability. | 2015 | Aging Cell | pmid:25757594 |
| Ma WW et al. | The oxysterol 27-hydroxycholesterol increases oxidative stress and regulate Nrf2 signaling pathway in astrocyte cells. | 2015 | Neurochem. Res. | pmid:25630716 |
| Bandaru VV and Haughey NJ | Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum. | 2014 | BMC Neurosci | pmid:25539717 |
| Civra A et al. | Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol. | 2014 | Sci Rep | pmid:25501851 |
| Kim SM et al. | 27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide. | 2015 | Biochim. Biophys. Acta | pmid:25497142 |
| Virginio VW et al. | Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activity. | 2015 | Free Radic. Res. | pmid:25465091 |
| Nelson ER et al. | Cholesterol and breast cancer pathophysiology. | 2014 | Trends Endocrinol. Metab. | pmid:25458418 |
| Heverin M et al. | 27-hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice. | 2015 | Behav. Brain Res. | pmid:25453744 |
| McDonnell DP et al. | The estrogen receptor as a mediator of the pathological actions of cholesterol in breast cancer. | 2014 | Climacteric | pmid:25320023 |
| Hendrikx T et al. | Hematopoietic overexpression of Cyp27a1 reduces hepatic inflammation independently of 27-hydroxycholesterol levels in Ldlr(-/-) mice. | 2015 | J. Hepatol. | pmid:25281859 |
| Wicher G and Norlin M | Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis. | 2015 | J. Steroid Biochem. Mol. Biol. | pmid:25263657 |