22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Neil HA et al. | Impact of atorvastatin and omega-3 ethyl esters 90 on plasma plant sterol concentrations and cholesterol synthesis in type 2 diabetes: a randomised placebo controlled factorial trial. | 2010 | Atherosclerosis | pmid:21036355 |
| Bhattacharyya AK and Eggen DA | Studies on the mechanism of high intestinal absorption of cholesterol and campesterol in high-responding rhesus monkeys. | 1988 | Atherosclerosis | pmid:3214463 |
| Mensink RP et al. | Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. | 2002 | Atherosclerosis | pmid:11755939 |
| Ntanios FY et al. | Effects of various amounts of dietary plant sterol esters on plasma and hepatic sterol concentration and aortic foam cell formation of cholesterol-fed hamsters. | 2003 | Atherosclerosis | pmid:12860249 |
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| Niesor EJ et al. | Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects. | 2011 | Atherosclerosis | pmid:21982411 |
| Miettinen TA et al. | Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: the cardiovascular risk in Young Finns Study. | 2008 | Atherosclerosis | pmid:18178213 |
| Noto D et al. | Plasma non-cholesterol sterols in primary hypobetalipoproteinemia. | 2011 | Atherosclerosis | pmid:21492858 |
| Schött HF et al. | The relationships of phytosterols and oxyphytosterols in plasma and aortic valve cusps in patients with severe aortic stenosis. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24631689 |
| KALLIANOS AG et al. | Identification of the D-glucosides of stigmasterol, sitosterol and campesterol in tobacco and cigarette smoke. | 1963 | Biochem. J. | pmid:14030353 |
| Bhadra S and Subbiah MT | Incorporation of liposomal phytosterols into human cells in culture: a potential in vitro model for investigating pathological effects of phytosterolemia. | 1991 | Biochem. Med. Metab. Biol. | pmid:1931153 |
| Schuler I et al. | Soybean phosphatidylcholine vesicles containing plant sterols: a fluorescence anisotropy study. | 1990 | Biochim. Biophys. Acta | pmid:2207122 |
| Leikin AI and Brenner RR | Fatty acid desaturase activities are modulated by phytosterol incorporation in microsomes. | 1989 | Biochim. Biophys. Acta | pmid:2775772 |
| Mannock DA et al. | A comparative calorimetric and spectroscopic study of the effects of cholesterol and of the plant sterols β-sitosterol and stigmasterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. | 2015 | Biochim. Biophys. Acta | pmid:25911208 |
| Benesch MG and McElhaney RN | A comparative calorimetric study of the effects of cholesterol and the plant sterols campesterol and brassicasterol on the thermotropic phase behavior of dipalmitoylphosphatidylcholine bilayer membranes. | 2014 | Biochim. Biophys. Acta | pmid:24704414 |
| Ikeda I et al. | Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats. | 2006 | Biochim. Biophys. Acta | pmid:16616424 |
| Ntanios FY and Jones PJ | Effects of variable dietary sitostanol concentrations on plasma lipid profile and phytosterol metabolism in hamsters. | 1998 | Biochim. Biophys. Acta | pmid:9487145 |
| Milhaud J et al. | Interaction of the polyene antibiotic filipin with model and natural membranes containing plant sterols. | 1988 | Biochim. Biophys. Acta | pmid:3401484 |