22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moreno-Anzúrez NE et al. | A Cytotoxic and Anti-inflammatory Campesterol Derivative from Genetically Transformed Hairy Roots of Lopezia racemosa Cav. (Onagraceae). | 2017 | Molecules | pmid:28085103 |
| Salinas R et al. | Production of the anti-inflammatory compound 6-O-palmitoyl-3-O-β-D-glucopyranosylcampesterol by Callus cultures of Lopezia racemosa Cav. (Onagraceae). | 2014 | Molecules | pmid:24962399 |
| Malek SN et al. | Cytotoxic components of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. | 2009 | Molecules | pmid:19471192 |
| Morrison AH and Ritter KS | Effect of host insect sterols on the development and sterol composition of Steinernema feltiae. | 1986 | Mol. Biochem. Parasitol. | pmid:3724794 |
| Labonté MÈ et al. | Comparison of the impact of trans fatty acids from ruminant and industrial sources on surrogate markers of cholesterol homeostasis in healthy men. | 2011 | Mol Nutr Food Res | pmid:21656668 |
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| Plat J et al. | Preferential campesterol incorporation into various tissues in apolipoprotein E*3-Leiden mice consuming plant sterols or stanols. | 2008 | Metab. Clin. Exp. | pmid:18702950 |
| Kempen HJ et al. | Lathosterol level in plasma is elevated in type III hyperlipoproteinemia, but not in non-type III subjects with apolipoprotein E2/2 phenotype, nor in type IIa or IIb hyperlipoproteinemia. | 1991 | Metab. Clin. Exp. | pmid:2000034 |
| Sudhop T et al. | Serum plant sterols as a potential risk factor for coronary heart disease. | 2002 | Metab. Clin. Exp. | pmid:12489060 |
| Ikeda I et al. | Mechanisms of phytosterolemia in stroke-prone spontaneously hypertensive and WKY rats. | 2001 | Metab. Clin. Exp. | pmid:11699058 |
| Nguyen TT et al. | Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: a randomized controlled trial. | 1999 | Mayo Clin. Proc. | pmid:10593347 |
| Hallikainen M et al. | Cholesterol metabolism and serum non-cholesterol sterols: summary of 13 plant stanol ester interventions. | 2014 | Lipids Health Dis | pmid:24766766 |
| Mo S et al. | Quantitative analysis of phytosterols in edible oils using APCI liquid chromatography-tandem mass spectrometry. | 2013 | Lipids | pmid:23884629 |
| Forchielli ML et al. | The spectrum of plant and animal sterols in different oil-derived intravenous emulsions. | 2010 | Lipids | pmid:20049583 |
| Lupattelli G et al. | Cholesterol metabolism differs after statin therapy according to the type of hyperlipemia. | 2012 | Life Sci. | pmid:22554491 |
| Barbosa SP et al. | Effects of ezetimibe on markers of synthesis and absorption of cholesterol in high-risk patients with elevated C-reactive protein. | 2013 | Life Sci. | pmid:23507424 |
| Tilvis RS et al. | Cholesterol and all-cause mortality in Honolulu. | 2001 | Lancet | pmid:11741659 |
| Nasu K et al. | Impact of cholesterol metabolism on coronary plaque vulnerability of target vessels: a combined analysis of virtual histology intravascular ultrasound and optical coherence tomography. | 2013 | JACC Cardiovasc Interv | pmid:23769651 |
| Sharma M et al. | Inhibition of sterol biosynthesis reduces tombusvirus replication in yeast and plants. | 2010 | J. Virol. | pmid:20015981 |
| Weingärtner O et al. | Plant sterol ester diet supplementation increases serum plant sterols and markers of cholesterol synthesis, but has no effect on total cholesterol levels. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27473562 |