22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lindenthal B et al. | Serum plant sterols and biliary cholesterol secretion in humans: studies with ursodeoxycholic acid. | 2002 | J. Lipid Res. | pmid:12091491 |
| Nissinen M et al. | Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12016126 |
| Ostlund RE et al. | Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11882512 |
| Brämswig S et al. | Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11788421 |
| Schaeffer A et al. | The ratio of campesterol to sitosterol that modulates growth in Arabidopsis is controlled by STEROL METHYLTRANSFERASE 2;1. | 2001 | Plant J. | pmid:11319028 |
| Normén AL et al. | Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. | 2001 | Am. J. Clin. Nutr. | pmid:11451730 |
| Meguro S et al. | Solubilization of phytosterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect. | 2001 | Eur J Clin Nutr | pmid:11464223 |
| Li JH et al. | Measurement variability of plasma beta-sitosterol and campesterol, two new biomarkers for cancer prevention. | 2001 | Eur. J. Cancer Prev. | pmid:11432711 |
| Relas H et al. | Acute effect of dietary stanyl ester dose on post-absorptive alpha-tocopherol, beta-carotene, retinol and retinyl palmitate concentrations. | 2001 | Br. J. Nutr. | pmid:11242481 |
| Tammi A et al. | Dietary plant sterols alter the serum plant sterol concentration but not the cholesterol precursor sterol concentrations in young children (the STRIP Study). Special Turku Coronary Risk Factor Intervention Project. | 2001 | J. Nutr. | pmid:11435511 |
| Tilvis RS et al. | Cholesterol and all-cause mortality in Honolulu. | 2001 | Lancet | pmid:11741659 |
| Relas H et al. | Fate of intravenously administered squalene and plant sterols in human subjects. | 2001 | J. Lipid Res. | pmid:11369807 |
| Ikeda I et al. | Mechanisms of phytosterolemia in stroke-prone spontaneously hypertensive and WKY rats. | 2001 | Metab. Clin. Exp. | pmid:11699058 |
| Awad AB et al. | In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells. | 2001 | Eur. J. Cancer Prev. | pmid:11916349 |
| Miettinen TA et al. | Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. | 2000 | Am. J. Clin. Nutr. | pmid:10799370 |
| Rajaratnam RA et al. | Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. | 2000 | J. Am. Coll. Cardiol. | pmid:10758959 |
| Relas H et al. | Dietary squalene increases cholesterol synthesis measured with serum non-cholesterol sterols after a single oral dose in humans. | 2000 | Atherosclerosis | pmid:10998465 |
| Miettinen TA et al. | Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10807752 |
| Song YS et al. | Identification of metabolites of phytosterols in rat feces using GC/MS. | 2000 | Arch. Pharm. Res. | pmid:11156182 |
| Awad AB et al. | Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture. | 2000 | Int. J. Mol. Med. | pmid:10762659 |
| Seto H et al. | Synthesis of 6-oxy functionalized campest-4-en-3-ones: efficient hydroperoxidation at C-6 of campest-5-en-3-one with molecular oxygen and silica gel. | 2000 | Steroids | pmid:10936615 |
| Salen G et al. | Hyperabsorption and retention of campestanol in a sitosterolemic homozygote: comparison with her mother and three control subjects. | 2000 | J. Lipid Res. | pmid:11060358 |
| Sanders DJ et al. | The safety evaluation of phytosterol esters. Part 6. The comparative absorption and tissue distribution of phytosterols in the rat. | 2000 | Food Chem. Toxicol. | pmid:10828500 |
| Noguchi T et al. | Arabidopsis det2 is defective in the conversion of (24R)-24-methylcholest-4-En-3-one to (24R)-24-methyl-5alpha-cholestan-3-one in brassinosteroid biosynthesis. | 1999 | Plant Physiol. | pmid:10398719 |
| Jones PJ et al. | Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. | 1999 | Am. J. Clin. Nutr. | pmid:10357732 |
| Gylling H et al. | Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. | 1999 | J. Lipid Res. | pmid:10191283 |
| Bortolomeazzi R et al. | Mass spectrometry characterization of the 5alpha-, 7alpha-, and 7beta-hydroxy derivatives of beta-sitosterol, campesterol, stigmasterol, and brassicasterol. | 1999 | J. Agric. Food Chem. | pmid:10552610 |
| Mensenkamp AR et al. | Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver. | 1999 | J. Biol. Chem. | pmid:10585451 |
| Baker VA et al. | Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays. | 1999 | Food Chem. Toxicol. | pmid:10069478 |
| Nguyen TT et al. | Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: a randomized controlled trial. | 1999 | Mayo Clin. Proc. | pmid:10593347 |
| Strom SS et al. | Phytoestrogen intake and prostate cancer: a case-control study using a new database. | 1999 | Nutr Cancer | pmid:10227039 |
| Choe S et al. | The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to campesterol in brassinosteroid biosynthesis. | 1999 | Plant Physiol. | pmid:10069828 |
| Cui YJ et al. | Biotransformation of 24 alpha-methylcholesterol and 24 beta-methylcholesterol by yeast mutant GL7. | 1999 | J Asian Nat Prod Res | pmid:11261204 |
| Gylling H et al. | Oral guar gum treatment of intrahepatic cholestasis and pruritus in pregnant women: effects on serum cholestanol and other non-cholesterol sterols. | 1998 | Eur. J. Clin. Invest. | pmid:9650008 |
| Howell TJ et al. | Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding. | 1998 | J. Lipid Res. | pmid:9555952 |
| Klahre U et al. | The Arabidopsis DIMINUTO/DWARF1 gene encodes a protein involved in steroid synthesis. | 1998 | Plant Cell | pmid:9761794 |
| Schaller H et al. | Overexpression of an Arabidopsis cDNA encoding a sterol-C24(1)-methyltransferase in tobacco modifies the ratio of 24-methyl cholesterol to sitosterol and is associated with growth reduction. | 1998 | Plant Physiol. | pmid:9765531 |
| Ntanios FY and Jones PJ | Effects of variable dietary sitostanol concentrations on plasma lipid profile and phytosterol metabolism in hamsters. | 1998 | Biochim. Biophys. Acta | pmid:9487145 |
| Harsch M et al. | Effects of pravastatin on cholesterol metabolism of cholesterol-fed heterozygous WHHL rabbits. | 1998 | Br. J. Pharmacol. | pmid:9641543 |
| Del Puppo M et al. | Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway. | 1998 | J. Lipid Res. | pmid:9831637 |
| Srikumar TS et al. | Analysis of fecal bile acids and neutral steroids using gas-liquid chromatography. | 1998 | Ann. Nutr. Metab. | pmid:9745109 |
| Field FJ et al. | Effect of micellar beta-sitosterol on cholesterol metabolism in CaCo-2 cells. | 1997 | J. Lipid Res. | pmid:9162754 |
| Robins SJ and Fasulo JM | High density lipoproteins, but not other lipoproteins, provide a vehicle for sterol transport to bile. | 1997 | J. Clin. Invest. | pmid:9022069 |
| Fujioka S et al. | The Arabidopsis deetiolated2 mutant is blocked early in brassinosteroid biosynthesis. | 1997 | Plant Cell | pmid:9401120 |
| Gylling H and Miettinen TA | Cholesterol absorption, synthesis, and LDL metabolism in NIDDM. | 1997 | Diabetes Care | pmid:9028702 |
| Sakurai A and Fujioka S | Studies on biosynthesis of brassinosteroids. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9178548 |
| Ling WH and Jones PJ | Enhanced efficacy of sitostanol-containing versus sitostanol-free phytosterol mixtures in altering lipoprotein cholesterol levels and synthesis in rats. | 1995 | Atherosclerosis | pmid:8770325 |
| Locker PK et al. | Lifibrol: a novel lipid-lowering drug for the therapy of hypercholesterolemia. Lifibrol Study Group. | 1995 | Clin. Pharmacol. Ther. | pmid:7828385 |
| Lütjohann D et al. | Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment. | 1995 | J. Lipid Res. | pmid:7595097 |
| Miettinen TA et al. | Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. | 1995 | N. Engl. J. Med. | pmid:7566021 |