22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Howell TJ et al. | Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding. | 1998 | J. Lipid Res. | pmid:9555952 |
| Field FJ et al. | Effect of micellar beta-sitosterol on cholesterol metabolism in CaCo-2 cells. | 1997 | J. Lipid Res. | pmid:9162754 |
| Robins SJ and Fasulo JM | High density lipoproteins, but not other lipoproteins, provide a vehicle for sterol transport to bile. | 1997 | J. Clin. Invest. | pmid:9022069 |
| Fujioka S et al. | The Arabidopsis deetiolated2 mutant is blocked early in brassinosteroid biosynthesis. | 1997 | Plant Cell | pmid:9401120 |
| Gylling H and Miettinen TA | Cholesterol absorption, synthesis, and LDL metabolism in NIDDM. | 1997 | Diabetes Care | pmid:9028702 |
| Sakurai A and Fujioka S | Studies on biosynthesis of brassinosteroids. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9178548 |
| Ling WH and Jones PJ | Enhanced efficacy of sitostanol-containing versus sitostanol-free phytosterol mixtures in altering lipoprotein cholesterol levels and synthesis in rats. | 1995 | Atherosclerosis | pmid:8770325 |
| Locker PK et al. | Lifibrol: a novel lipid-lowering drug for the therapy of hypercholesterolemia. Lifibrol Study Group. | 1995 | Clin. Pharmacol. Ther. | pmid:7828385 |
| Lütjohann D et al. | Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment. | 1995 | J. Lipid Res. | pmid:7595097 |
| Miettinen TA et al. | Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. | 1995 | N. Engl. J. Med. | pmid:7566021 |
| Davis RH et al. | Aloe vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation. | 1994 | J Am Podiatr Med Assoc | pmid:7853156 |
| Zeeck E et al. | Sex pheromones in marine polychaetes: steroids from ripe Nereis succinea. | 1994 | Steroids | pmid:8073448 |
| Heinemann T et al. | Comparison of intestinal absorption of cholesterol with different plant sterols in man. | 1993 | Eur. J. Clin. Invest. | pmid:8143759 |
| Sutherland WH et al. | Plasma non-cholesterol sterols in patients with non-insulin dependent diabetes mellitus. | 1992 | Horm. Metab. Res. | pmid:1601392 |
| Vanhanen HT and Miettinen TA | Effects of unsaturated and saturated dietary plant sterols on their serum contents. | 1992 | Clin. Chim. Acta | pmid:1521345 |
| Nikkilä K et al. | Liver transplantation modifies serum cholestanol, cholesterol precursor and plant sterol levels. | 1992 | Clin. Chim. Acta | pmid:1499139 |
| van Dusseldorp M et al. | Cholesterol-raising factor from boiled coffee does not pass a paper filter. | 1991 May-Jun | Arterioscler. Thromb. | pmid:2029499 |
| Kempen HJ et al. | Lathosterol level in plasma is elevated in type III hyperlipoproteinemia, but not in non-type III subjects with apolipoprotein E2/2 phenotype, nor in type IIa or IIb hyperlipoproteinemia. | 1991 | Metab. Clin. Exp. | pmid:2000034 |
| Bhadra S and Subbiah MT | Incorporation of liposomal phytosterols into human cells in culture: a potential in vitro model for investigating pathological effects of phytosterolemia. | 1991 | Biochem. Med. Metab. Biol. | pmid:1931153 |
| Nikkilä K et al. | High cholestanol and low campesterol-to-sitosterol ratio in serum of patients with primary biliary cirrhosis before liver transplantation. | 1991 | Hepatology | pmid:2010161 |