22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lembcke J et al. | Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS/MS. | 2005 | J. Lipid Res. | pmid:15489546 |
| Plat J et al. | Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers. | 2005 | J. Lipid Res. | pmid:15520451 |
| Nikkilä K et al. | Sterol parameters as markers of liver function in primary biliary cirrhosis before and after liver transplantation. | 2005 | Transpl. Int. | pmid:15691276 |
| Yokosuka A et al. | New glycosides of the campesterol derivative from the rhizomes of Tacca chantrieri. | 2005 | Steroids | pmid:15784281 |
| Yu L et al. | Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8. | 2005 | J. Lipid Res. | pmid:15930515 |
| Miettinen TA et al. | Plant sterols in serum and in atherosclerotic plaques of patients undergoing carotid endarterectomy. | 2005 | J. Am. Coll. Cardiol. | pmid:15936608 |
| Hong Z et al. | The Rice brassinosteroid-deficient dwarf2 mutant, defective in the rice homolog of Arabidopsis DIMINUTO/DWARF1, is rescued by the endogenously accumulated alternative bioactive brassinosteroid, dolichosterone. | 2005 | Plant Cell | pmid:15994910 |
| Päivä H et al. | High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial. | 2005 | Clin. Pharmacol. Ther. | pmid:16003294 |
| Sutherland WH et al. | Plasma non-cholesterol sterols in patients with non-insulin dependent diabetes mellitus. | 1992 | Horm. Metab. Res. | pmid:1601392 |
| Awad AB et al. | beta-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells. | 2005 | J. Nutr. Biochem. | pmid:16098730 |
| Ho SS and Pal S | Margarine phytosterols decrease the secretion of atherogenic lipoproteins from HepG2 liver and Caco2 intestinal cells. | 2005 | Atherosclerosis | pmid:16115472 |
| Conchillo A et al. | Levels of phytosterol oxides in enriched and nonenriched spreads: application of a thin-layer chromatography-gas chromatography methodology. | 2005 | J. Agric. Food Chem. | pmid:16190640 |
| Xu F et al. | Dual roles for cholesterol in mammalian cells. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16199524 |
| Takahashi K et al. | Metabolic conversion of 24-methyl-Delta25-cholesterol to 24-methylcholesterol in higher plants. | 2006 | Bioorg. Med. Chem. | pmid:16213729 |
| de Jong A et al. | Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment. | 2006 | Eur J Clin Nutr | pmid:16482072 |
| Hedman M et al. | Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy. | 2006 | J. Pediatr. | pmid:16492436 |
| Takahashi K et al. | Purification and ATPase activity of human ABCA1. | 2006 | J. Biol. Chem. | pmid:16500904 |
| Sorenson WR and Sullivan D | Determination of campesterol, stigmasterol, and beta-sitosterol in saw palmetto raw materials and dietary supplements by gas chromatography: single-laboratory validation. | 2006 Jan-Feb | J AOAC Int | pmid:16512224 |
| Gerloff T et al. | Influence of the SLCO1B1*1b and *5 haplotypes on pravastatin's cholesterol lowering capabilities and basal sterol serum levels. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16568260 |
| Ikeda I et al. | Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats. | 2006 | Biochim. Biophys. Acta | pmid:16616424 |