22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:25701095 | ||||
| pmid:27591043 | ||||
| pmid:27565790 | ||||
| pmid:26447847 | ||||
| pmid:25683892 | ||||
| pmid:26888803 | ||||
| pmid:27035112 | ||||
| pmid:25281277 | ||||
| pmid:28911735 | ||||
| pmid:26593514 | ||||
| pmid:24749735 | ||||
| pmid:24747138 | ||||
| pmid:25656784 | ||||
| pmid:28357621 | ||||
| pmid:24394292 | ||||
| pmid:26692575 | ||||
| pmid:28812011 | ||||
| pmid:24909799 | ||||
| pmid:26228672 | ||||
| pmid:25373930 | ||||
| pmid:26522347 | ||||
| pmid:26803301 | ||||
| pmid:26651578 | ||||
| pmid:25466113 | ||||
| pmid:26940357 | ||||
| pmid:25463087 | ||||
| pmid:26935127 | ||||
| pmid:26921766 | ||||
| pmid:18155865 | ||||
| pmid:26913457 | ||||
| pmid:29345907 | ||||
| pmid:25860174 | ||||
| pmid: | ||||
| Vanstone CA et al. | Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons. | 2002 | Am. J. Clin. Nutr. | pmid:12450893 |
| Jones PJ et al. | Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. | 1999 | Am. J. Clin. Nutr. | pmid:10357732 |
| Miettinen TA et al. | Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. | 2000 | Am. J. Clin. Nutr. | pmid:10799370 |
| Normén AL et al. | Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. | 2001 | Am. J. Clin. Nutr. | pmid:11451730 |
| Ras RT et al. | The effect of a low-fat spread with added plant sterols on vascular function markers: results of the Investigating Vascular Function Effects of Plant Sterols (INVEST) study. | 2015 | Am. J. Clin. Nutr. | pmid:25809853 |
| Hansel B et al. | Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia. | 2007 | Am. J. Clin. Nutr. | pmid:17823447 |
| Rosqvist F et al. | Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study. | 2015 | Am. J. Clin. Nutr. | pmid:26016870 |
| Wang C et al. | A unique patient with coexisting cerebrotendinous xanthomatosis and beta-sitosterolemia. | 1981 | Am. J. Med. | pmid:7258222 |
| Ostlund RE et al. | Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11882512 |
| Nissinen M et al. | Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12016126 |
| Brämswig S et al. | Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11788421 |
| Schröder M and Vetter W | High-speed counter-current chromatographic separation of phytosterols. | 2011 | Anal Bioanal Chem | pmid:21499948 |
| Ito N et al. | An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco-2 cells. | 2012 | Anal. Biochem. | pmid:22119071 |
| Bhattacharyya AK and Eggen DA | Effect of dietary cholesterol level on plasma campesterol concentration in rhesus monkeys. | 1987 | Ann. Nutr. Metab. | pmid:3662438 |
| Chen Q et al. | Dietary phytosterols and phytostanols alter the expression of sterol-regulatory genes in SHRSP and WKY inbred rats. | 2009 | Ann. Nutr. Metab. | pmid:19851062 |
| Srikumar TS et al. | Analysis of fecal bile acids and neutral steroids using gas-liquid chromatography. | 1998 | Ann. Nutr. Metab. | pmid:9745109 |
| Zhang S et al. | Identification of a sterol Delta7 reductase gene involved in desmosterol biosynthesis in Mortierella alpina 1S-4. | 2007 | Appl. Environ. Microbiol. | pmid:17220261 |
| Song YS et al. | Identification of metabolites of phytosterols in rat feces using GC/MS. | 2000 | Arch. Pharm. Res. | pmid:11156182 |
| van Dusseldorp M et al. | Cholesterol-raising factor from boiled coffee does not pass a paper filter. | 1991 May-Jun | Arterioscler. Thromb. | pmid:2029499 |
| Miettinen TA et al. | Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10807752 |
| van Himbergen TM et al. | Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:19834104 |
| Devaraj S et al. | Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14764424 |
| Ling WH and Jones PJ | Enhanced efficacy of sitostanol-containing versus sitostanol-free phytosterol mixtures in altering lipoprotein cholesterol levels and synthesis in rats. | 1995 | Atherosclerosis | pmid:8770325 |
| Neil HA et al. | Impact of atorvastatin and omega-3 ethyl esters 90 on plasma plant sterol concentrations and cholesterol synthesis in type 2 diabetes: a randomised placebo controlled factorial trial. | 2010 | Atherosclerosis | pmid:21036355 |
| Brindisi MC et al. | Liver fat content is associated with an increase in cholesterol synthesis independent of statin therapy use in patients with type 2 diabetes. | 2012 | Atherosclerosis | pmid:22959662 |
| Bhattacharyya AK and Eggen DA | Studies on the mechanism of high intestinal absorption of cholesterol and campesterol in high-responding rhesus monkeys. | 1988 | Atherosclerosis | pmid:3214463 |
| Mensink RP et al. | Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. | 2002 | Atherosclerosis | pmid:11755939 |
| Okada K et al. | Long-term effects of ezetimibe-plus-statin therapy on low-density lipoprotein cholesterol levels as compared with double-dose statin therapy in patients with coronary artery disease. | 2012 | Atherosclerosis | pmid:22892323 |
| Relas H et al. | Dietary squalene increases cholesterol synthesis measured with serum non-cholesterol sterols after a single oral dose in humans. | 2000 | Atherosclerosis | pmid:10998465 |
| Ras RT et al. | Consumption of plant sterol-enriched foods and effects on plasma plant sterol concentrations--a meta-analysis of randomized controlled studies. | 2013 | Atherosclerosis | pmid:24075766 |
| Ntanios FY et al. | Effects of various amounts of dietary plant sterol esters on plasma and hepatic sterol concentration and aortic foam cell formation of cholesterol-fed hamsters. | 2003 | Atherosclerosis | pmid:12860249 |
| Bhattacharyya AK and Eggen DA | Effects of feeding cholesterol and mixed plant sterols on the fecal excretion of acidic steroids in rhesus monkeys. | 1984 | Atherosclerosis | pmid:6529445 |
| Miettinen TA et al. | Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: the Cardiovascular Risk in Young Finns Study. | 2010 | Atherosclerosis | pmid:19963215 |
| Ho SS and Pal S | Margarine phytosterols decrease the secretion of atherogenic lipoproteins from HepG2 liver and Caco2 intestinal cells. | 2005 | Atherosclerosis | pmid:16115472 |
| Niesor EJ et al. | Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects. | 2011 | Atherosclerosis | pmid:21982411 |
| Miettinen TA et al. | Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: the cardiovascular risk in Young Finns Study. | 2008 | Atherosclerosis | pmid:18178213 |
| Noto D et al. | Plasma non-cholesterol sterols in primary hypobetalipoproteinemia. | 2011 | Atherosclerosis | pmid:21492858 |
| Schött HF et al. | The relationships of phytosterols and oxyphytosterols in plasma and aortic valve cusps in patients with severe aortic stenosis. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24631689 |
| KALLIANOS AG et al. | Identification of the D-glucosides of stigmasterol, sitosterol and campesterol in tobacco and cigarette smoke. | 1963 | Biochem. J. | pmid:14030353 |
| Bhadra S and Subbiah MT | Incorporation of liposomal phytosterols into human cells in culture: a potential in vitro model for investigating pathological effects of phytosterolemia. | 1991 | Biochem. Med. Metab. Biol. | pmid:1931153 |
| Schuler I et al. | Soybean phosphatidylcholine vesicles containing plant sterols: a fluorescence anisotropy study. | 1990 | Biochim. Biophys. Acta | pmid:2207122 |
| Leikin AI and Brenner RR | Fatty acid desaturase activities are modulated by phytosterol incorporation in microsomes. | 1989 | Biochim. Biophys. Acta | pmid:2775772 |
| Mannock DA et al. | A comparative calorimetric and spectroscopic study of the effects of cholesterol and of the plant sterols β-sitosterol and stigmasterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes. | 2015 | Biochim. Biophys. Acta | pmid:25911208 |
| Benesch MG and McElhaney RN | A comparative calorimetric study of the effects of cholesterol and the plant sterols campesterol and brassicasterol on the thermotropic phase behavior of dipalmitoylphosphatidylcholine bilayer membranes. | 2014 | Biochim. Biophys. Acta | pmid:24704414 |
| Ikeda I et al. | Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats. | 2006 | Biochim. Biophys. Acta | pmid:16616424 |
| Ntanios FY and Jones PJ | Effects of variable dietary sitostanol concentrations on plasma lipid profile and phytosterol metabolism in hamsters. | 1998 | Biochim. Biophys. Acta | pmid:9487145 |
| Milhaud J et al. | Interaction of the polyene antibiotic filipin with model and natural membranes containing plant sterols. | 1988 | Biochim. Biophys. Acta | pmid:3401484 |
| O'Callaghan Y et al. | Synthesis and assessment of the relative toxicity of the oxidised derivatives of campesterol and dihydrobrassicasterol in U937 and HepG2 cells. | 2013 | Biochimie | pmid:22561884 |
| Takahashi K et al. | Metabolic conversion of 24-methyl-Delta25-cholesterol to 24-methylcholesterol in higher plants. | 2006 | Bioorg. Med. Chem. | pmid:16213729 |
| Sakurai A and Fujioka S | Studies on biosynthesis of brassinosteroids. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9178548 |
| Hallikainen M et al. | Short-term LDL cholesterol-lowering efficacy of plant stanol esters. | 2002 | BMC Cardiovasc Disord | pmid:12197945 |
| Belayachi L et al. | Retama monosperma n-hexane extract induces cell cycle arrest and extrinsic pathway-dependent apoptosis in Jurkat cells. | 2014 | BMC Complement Altern Med | pmid:24460687 |
| Renner O et al. | Role of the ABCG8 19H risk allele in cholesterol absorption and gallstone disease. | 2013 | BMC Gastroenterol | pmid:23406058 |
| Leyes P et al. | Effects of ezetimibe on cholesterol metabolism in HIV-infected patients with protease inhibitor-associated dyslipidemia: a single-arm intervention trial. | 2014 | BMC Infect. Dis. | pmid:25209653 |
| Klett EL et al. | A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. | 2004 | BMC Med | pmid:15040800 |
| Schrøder M et al. | Effect of rapeseed oil-derived plant sterol and stanol esters on atherosclerosis parameters in cholesterol-challenged heterozygous Watanabe heritable hyperlipidaemic rabbits. | 2009 | Br. J. Nutr. | pmid:19772679 |
| Laitinen K et al. | Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. | 2009 | Br. J. Nutr. | pmid:19017423 |
| Relas H et al. | Acute effect of dietary stanyl ester dose on post-absorptive alpha-tocopherol, beta-carotene, retinol and retinyl palmitate concentrations. | 2001 | Br. J. Nutr. | pmid:11242481 |
| Nissinen MJ et al. | Responses of surrogate markers of cholesterol absorption and synthesis to changes in cholesterol metabolism during various amounts of fat and cholesterol feeding among healthy men. | 2008 | Br. J. Nutr. | pmid:17697430 |
| De Graaf J et al. | Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. | 2002 | Br. J. Nutr. | pmid:12425728 |
| Harsch M et al. | Effects of pravastatin on cholesterol metabolism of cholesterol-fed heterozygous WHHL rabbits. | 1998 | Br. J. Pharmacol. | pmid:9641543 |
| Matsuoka K et al. | Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles. | 2008 | Chem. Phys. Lipids | pmid:18544343 |
| Husche C et al. | Validation of an isotope dilution gas chromatography-mass spectrometry method for analysis of 7-oxygenated campesterol and sitosterol in human serum. | 2011 | Chem. Phys. Lipids | pmid:21620808 |
| Nes WD | Biosynthesis of cholesterol and other sterols. | 2011 | Chem. Rev. | pmid:21902244 |
| Procházková T et al. | Phytoestrogens and sterols in waters with cyanobacterial blooms - Analytical methods and estrogenic potencies. | 2017 | Chemosphere | pmid:27974267 |
| Tse TJ et al. | Reconstructing long-term trends in municipal sewage discharge into a small lake in northern Manitoba, Canada. | 2014 | Chemosphere | pmid:24405965 |
| Salen G et al. | Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia. | 2004 | Circulation | pmid:14769702 |