22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:25701095 | ||||
| pmid:27591043 | ||||
| pmid:27565790 | ||||
| pmid:26447847 | ||||
| pmid:25683892 | ||||
| pmid:26888803 | ||||
| pmid:27035112 | ||||
| pmid:25281277 | ||||
| pmid:28911735 | ||||
| pmid:26593514 | ||||
| pmid:24749735 | ||||
| pmid:24747138 | ||||
| pmid:25656784 | ||||
| pmid:28357621 | ||||
| pmid:24394292 | ||||
| pmid:26692575 | ||||
| pmid:28812011 | ||||
| pmid:24909799 | ||||
| pmid:26228672 | ||||
| pmid:25373930 | ||||
| pmid:26522347 | ||||
| pmid:26803301 | ||||
| pmid:26651578 | ||||
| pmid:25466113 | ||||
| pmid:26940357 | ||||
| pmid:25463087 | ||||
| pmid:26935127 | ||||
| pmid:26921766 | ||||
| pmid:18155865 | ||||
| pmid:26913457 | ||||
| pmid:29345907 | ||||
| pmid:25860174 | ||||
| pmid: | ||||
| Vanstone CA et al. | Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons. | 2002 | Am. J. Clin. Nutr. | pmid:12450893 |
| Jones PJ et al. | Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. | 1999 | Am. J. Clin. Nutr. | pmid:10357732 |
| Miettinen TA et al. | Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. | 2000 | Am. J. Clin. Nutr. | pmid:10799370 |
| Normén AL et al. | Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. | 2001 | Am. J. Clin. Nutr. | pmid:11451730 |
| Ras RT et al. | The effect of a low-fat spread with added plant sterols on vascular function markers: results of the Investigating Vascular Function Effects of Plant Sterols (INVEST) study. | 2015 | Am. J. Clin. Nutr. | pmid:25809853 |
| Hansel B et al. | Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia. | 2007 | Am. J. Clin. Nutr. | pmid:17823447 |
| Rosqvist F et al. | Potential role of milk fat globule membrane in modulating plasma lipoproteins, gene expression, and cholesterol metabolism in humans: a randomized study. | 2015 | Am. J. Clin. Nutr. | pmid:26016870 |
| Wang C et al. | A unique patient with coexisting cerebrotendinous xanthomatosis and beta-sitosterolemia. | 1981 | Am. J. Med. | pmid:7258222 |
| Ostlund RE et al. | Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11882512 |
| Nissinen M et al. | Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12016126 |
| Brämswig S et al. | Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11788421 |
| Schröder M and Vetter W | High-speed counter-current chromatographic separation of phytosterols. | 2011 | Anal Bioanal Chem | pmid:21499948 |
| Ito N et al. | An ultra performance liquid chromatographic method for determining phytosterol uptake by Caco-2 cells. | 2012 | Anal. Biochem. | pmid:22119071 |
| Bhattacharyya AK and Eggen DA | Effect of dietary cholesterol level on plasma campesterol concentration in rhesus monkeys. | 1987 | Ann. Nutr. Metab. | pmid:3662438 |
| Chen Q et al. | Dietary phytosterols and phytostanols alter the expression of sterol-regulatory genes in SHRSP and WKY inbred rats. | 2009 | Ann. Nutr. Metab. | pmid:19851062 |
| Srikumar TS et al. | Analysis of fecal bile acids and neutral steroids using gas-liquid chromatography. | 1998 | Ann. Nutr. Metab. | pmid:9745109 |
| Zhang S et al. | Identification of a sterol Delta7 reductase gene involved in desmosterol biosynthesis in Mortierella alpina 1S-4. | 2007 | Appl. Environ. Microbiol. | pmid:17220261 |