22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tsukagoshi Y et al. | Ajuga Δ24-Sterol Reductase Catalyzes the Direct Reductive Conversion of 24-Methylenecholesterol to Campesterol. | 2016 | J. Biol. Chem. | pmid:26872973 |
| Mensenkamp AR et al. | Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver. | 1999 | J. Biol. Chem. | pmid:10585451 |
| Takahashi K et al. | Purification and ATPase activity of human ABCA1. | 2006 | J. Biol. Chem. | pmid:16500904 |
| Graf GA et al. | ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. | 2003 | J. Biol. Chem. | pmid:14504269 |
| Boberg KM et al. | Formation of C21 bile acids from plant sterols in the rat. | 1990 | J. Biol. Chem. | pmid:2335512 |
| Robins SJ and Fasulo JM | High density lipoproteins, but not other lipoproteins, provide a vehicle for sterol transport to bile. | 1997 | J. Clin. Invest. | pmid:9022069 |
| Yang C et al. | Disruption of cholesterol homeostasis by plant sterols. | 2004 | J. Clin. Invest. | pmid:15372105 |
| Rossard S et al. | Ergosterol triggers characteristic elicitation steps in Beta vulgaris leaf tissues. | 2010 | J. Exp. Bot. | pmid:20304987 |
| Ho XL and Loke WM | Dietary Plant Sterols Supplementation Increases In Vivo Nitrite and Nitrate Production in Healthy Adults: A Randomized, Controlled Study. | 2017 | J. Food Sci. | pmid:28708316 |
| Whitaker BD and Nelson DL | Sterol synergism in Paramecium tetraurelia. | 1988 | J. Gen. Microbiol. | pmid:3221193 |
| Gälman C et al. | Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19. | 2011 | J. Intern. Med. | pmid:22003820 |
| Ketomaki A et al. | Effects of plant stanol and sterol esters on serum phytosterols in a family with familial hypercholesterolemia including a homozygous subject. | 2004 | J. Lab. Clin. Med. | pmid:15085084 |
| Miettinen TA et al. | Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. | 2003 | J. Lab. Clin. Med. | pmid:12577049 |
| Silbernagel G et al. | The associations of cholesterol metabolism and plasma plant sterols with all-cause and cardiovascular mortality. | 2010 | J. Lipid Res. | pmid:20228406 |
| Jakulj L et al. | Baseline cholesterol absorption and the response to ezetimibe/simvastatin therapy: a post-hoc analysis of the ENHANCE trial. | 2010 | J. Lipid Res. | pmid:19828909 |
| Howell TJ et al. | Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding. | 1998 | J. Lipid Res. | pmid:9555952 |
| Gylling H et al. | Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. | 1999 | J. Lipid Res. | pmid:10191283 |
| Field FJ et al. | Effect of micellar beta-sitosterol on cholesterol metabolism in CaCo-2 cells. | 1997 | J. Lipid Res. | pmid:9162754 |
| Shafaati M et al. | Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation. | 2011 | J. Lipid Res. | pmid:21335619 |
| Del Puppo M et al. | Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway. | 1998 | J. Lipid Res. | pmid:9831637 |