22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Miettinen TA et al. | Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: the Cardiovascular Risk in Young Finns Study. | 2010 | Atherosclerosis | pmid:19963215 |
| Ooi EM et al. | Plasma markers of cholesterol homeostasis in metabolic syndrome subjects with or without type-2 diabetes. | 2009 | Diabetes Res. Clin. Pract. | pmid:19573945 |
| Miettinen TA et al. | Twenty-one year tracking of serum non-cholesterol sterols. The Cardiovascular Risk in Young Finns study. | 2009 | Nutr Metab Cardiovasc Dis | pmid:19185477 |
| Shay CM et al. | Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study. | 2009 | J Diabetes | pmid:20827426 |
| Schrøder M et al. | Effect of rapeseed oil-derived plant sterol and stanol esters on atherosclerosis parameters in cholesterol-challenged heterozygous Watanabe heritable hyperlipidaemic rabbits. | 2009 | Br. J. Nutr. | pmid:19772679 |
| Weingärtner O et al. | Alterations in cholesterol homeostasis are associated with coronary heart disease in patients with aortic stenosis. | 2009 | Coron. Artery Dis. | pmid:19620855 |
| Laitinen K et al. | Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety. | 2009 | Br. J. Nutr. | pmid:19017423 |
| Escurriol V et al. | Serum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet. | 2009 | Eur J Nutr | pmid:19412676 |
| Han JH et al. | [Comparison of the dietary phytosterols intake and serum lipids content in elderly women from three cities of China]. | 2009 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:20193499 |
| Malek SN et al. | Cytotoxic components of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. | 2009 | Molecules | pmid:19471192 |
| Herchi W et al. | Phytosterols accumulation in the seeds of Linum usitatissimum L. | 2009 | Plant Physiol. Biochem. | pmid:19616960 |
| Wang L et al. | OsGSR1 is involved in crosstalk between gibberellins and brassinosteroids in rice. | 2009 | Plant J. | pmid:18980660 |
| Silbernagel G et al. | The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease. | 2009 | J. Lipid Res. | pmid:18769018 |
| Daly TJ et al. | Lack of genoprotective effect of phytosterols and conjugated linoleic acids on Caco-2 cells. | 2009 | Food Chem. Toxicol. | pmid:19406198 |
| Chen Q et al. | Dietary phytosterols and phytostanols alter the expression of sterol-regulatory genes in SHRSP and WKY inbred rats. | 2009 | Ann. Nutr. Metab. | pmid:19851062 |
| Houweling AH et al. | Baseline plasma plant sterol concentrations do not predict changes in serum lipids, C-reactive protein (CRP) and plasma plant sterols following intake of a plant sterol-enriched food. | 2009 | Eur J Clin Nutr | pmid:18073779 |
| Banerji R et al. | Oil and fatty acid diversity in genetically variable clones of Moringa oleifera from India. | 2009 | J Oleo Sci | pmid:19075502 |
| van Himbergen TM et al. | Comparison of the effects of maximal dose atorvastatin and rosuvastatin therapy on cholesterol synthesis and absorption markers. | 2009 | J. Lipid Res. | pmid:19043140 |
| Plat J et al. | Preferential campesterol incorporation into various tissues in apolipoprotein E*3-Leiden mice consuming plant sterols or stanols. | 2008 | Metab. Clin. Exp. | pmid:18702950 |
| Aherne SA and O'Brien NM | Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells. | 2008 | Mol Nutr Food Res | pmid:18465778 |
| Matsuoka K et al. | Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles. | 2008 | Chem. Phys. Lipids | pmid:18544343 |
| Kpoviéssi DS et al. | Validation of a method for the determination of sterols and triterpenes in the aerial part of Justicia anselliana (Nees) T. Anders by capillary gas chromatography. | 2008 | J Pharm Biomed Anal | pmid:18951746 |
| Nissinen MJ et al. | Responses of surrogate markers of cholesterol absorption and synthesis to changes in cholesterol metabolism during various amounts of fat and cholesterol feeding among healthy men. | 2008 | Br. J. Nutr. | pmid:17697430 |
| Miettinen TA et al. | Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: the cardiovascular risk in Young Finns Study. | 2008 | Atherosclerosis | pmid:18178213 |
| Assmann G et al. | Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe-statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia. | 2008 | Curr Med Res Opin | pmid:18053317 |
| GarcÃa-Llatas G et al. | Sterol oxidation in ready-to-eat infant foods during storage. | 2008 | J. Agric. Food Chem. | pmid:18167071 |
| Sorenson WR and Sullivan D | Determination of campesterol, stigmasterol, and beta-sitosterol in saw palmetto raw materials and dietary supplements by gas chromatography: collaborative study. | 2007 May-Jun | J AOAC Int | pmid:17580618 |
| Fransen HP et al. | Customary use of plant sterol and plant stanol enriched margarine is associated with changes in serum plant sterol and stanol concentrations in humans. | 2007 | J. Nutr. | pmid:17449596 |
| Márk L and Paragh G | [Change in the cholesterol metabolism associated with the combined inhibition of synthesis and absorption]. | 2007 | Orv Hetil | pmid:17403635 |
| Hansel B et al. | Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia. | 2007 | Am. J. Clin. Nutr. | pmid:17823447 |
| Choi JM et al. | Identification of campesterol from Chrysanthemum coronarium L. and its antiangiogenic activities. | 2007 | Phytother Res | pmid:17604370 |
| Zhang S et al. | Identification of a sterol Delta7 reductase gene involved in desmosterol biosynthesis in Mortierella alpina 1S-4. | 2007 | Appl. Environ. Microbiol. | pmid:17220261 |
| Nagadome S et al. | Monolayers (Langmuir films) behavior of multi-component systems composed of a bile acid with different sterols and with their 1:1 mixtures. | 2007 | Colloids Surf B Biointerfaces | pmid:17482801 |
| Abramsson-Zetterberg L et al. | No evidence of genotoxic effect in vivo of the phytosterol oxidation products triols and epoxides. | 2007 | Toxicol. Lett. | pmid:17765410 |
| Pinedo S et al. | Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study. | 2007 | J. Lipid Res. | pmid:17074925 |
| Ryan E et al. | Fatty acid profile, tocopherol, squalene and phytosterol content of brazil, pecan, pine, pistachio and cashew nuts. | 2006 May-Jun | Int J Food Sci Nutr | pmid:17127473 |
| Sorenson WR and Sullivan D | Determination of campesterol, stigmasterol, and beta-sitosterol in saw palmetto raw materials and dietary supplements by gas chromatography: single-laboratory validation. | 2006 Jan-Feb | J AOAC Int | pmid:16512224 |
| Takahashi K et al. | Metabolic conversion of 24-methyl-Delta25-cholesterol to 24-methylcholesterol in higher plants. | 2006 | Bioorg. Med. Chem. | pmid:16213729 |
| Sabudak T et al. | Potent tyrosinase inhibitors from Trifolium balansae. | 2006 | Nat. Prod. Res. | pmid:16901809 |
| Ikeda I et al. | Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats. | 2006 | Biochim. Biophys. Acta | pmid:16616424 |
| Gerloff T et al. | Influence of the SLCO1B1*1b and *5 haplotypes on pravastatin's cholesterol lowering capabilities and basal sterol serum levels. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16568260 |
| Hedman M et al. | Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy. | 2006 | J. Pediatr. | pmid:16492436 |
| Takahashi K et al. | Purification and ATPase activity of human ABCA1. | 2006 | J. Biol. Chem. | pmid:16500904 |
| de Jong A et al. | Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment. | 2006 | Eur J Clin Nutr | pmid:16482072 |
| Oswald S et al. | Disposition and sterol-lowering effect of ezetimibe are influenced by single-dose coadministration of rifampin, an inhibitor of multidrug transport proteins. | 2006 | Clin. Pharmacol. Ther. | pmid:17112804 |
| Lembcke J et al. | Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS/MS. | 2005 | J. Lipid Res. | pmid:15489546 |
| Xu F et al. | Dual roles for cholesterol in mammalian cells. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16199524 |
| Nikkilä K et al. | Sterol parameters as markers of liver function in primary biliary cirrhosis before and after liver transplantation. | 2005 | Transpl. Int. | pmid:15691276 |
| Yokosuka A et al. | New glycosides of the campesterol derivative from the rhizomes of Tacca chantrieri. | 2005 | Steroids | pmid:15784281 |
| Yu L et al. | Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8. | 2005 | J. Lipid Res. | pmid:15930515 |
| Conchillo A et al. | Levels of phytosterol oxides in enriched and nonenriched spreads: application of a thin-layer chromatography-gas chromatography methodology. | 2005 | J. Agric. Food Chem. | pmid:16190640 |
| Miettinen TA et al. | Plant sterols in serum and in atherosclerotic plaques of patients undergoing carotid endarterectomy. | 2005 | J. Am. Coll. Cardiol. | pmid:15936608 |
| Päivä H et al. | High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial. | 2005 | Clin. Pharmacol. Ther. | pmid:16003294 |
| Plat J et al. | Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers. | 2005 | J. Lipid Res. | pmid:15520451 |
| Ho SS and Pal S | Margarine phytosterols decrease the secretion of atherogenic lipoproteins from HepG2 liver and Caco2 intestinal cells. | 2005 | Atherosclerosis | pmid:16115472 |
| Awad AB et al. | beta-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells. | 2005 | J. Nutr. Biochem. | pmid:16098730 |
| Hong Z et al. | The Rice brassinosteroid-deficient dwarf2 mutant, defective in the rice homolog of Arabidopsis DIMINUTO/DWARF1, is rescued by the endogenously accumulated alternative bioactive brassinosteroid, dolichosterone. | 2005 | Plant Cell | pmid:15994910 |
| Tomoyori H et al. | Phytosterol oxidation products are absorbed in the intestinal lymphatics in rats but do not accelerate atherosclerosis in apolipoprotein E-deficient mice. | 2004 | J. Nutr. | pmid:15226455 |
| Mongrand S et al. | Lipid rafts in higher plant cells: purification and characterization of Triton X-100-insoluble microdomains from tobacco plasma membrane. | 2004 | J. Biol. Chem. | pmid:15190066 |
| Nomura T et al. | Brassinosteroid deficiency due to truncated steroid 5alpha-reductase causes dwarfism in the lk mutant of pea. | 2004 | Plant Physiol. | pmid:15286289 |
| Amundsen AL et al. | Long-term compliance and changes in plasma lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol ester-enriched spread. | 2004 | Eur J Clin Nutr | pmid:15199384 |
| Devaraj S et al. | Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14764424 |
| Klett EL et al. | A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. | 2004 | BMC Med | pmid:15040800 |
| Bloks VW et al. | Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes. | 2004 | Diabetologia | pmid:14618236 |
| Ketomaki A et al. | Effects of plant stanol and sterol esters on serum phytosterols in a family with familial hypercholesterolemia including a homozygous subject. | 2004 | J. Lab. Clin. Med. | pmid:15085084 |
| Pakarinen MP et al. | Growth hormone selectively improves intestinal cholesterol absorption after jejunoileal autotransplantation in pigs. | 2004 | J. Pediatr. Surg. | pmid:15300531 |
| Delaney B et al. | Oral absorption of phytosterols and emulsified phytosterols by Sprague-Dawley rats. | 2004 | J. Nutr. Biochem. | pmid:15135153 |
| Plösch T et al. | Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. | 2004 | Gastroenterology | pmid:14699507 |
| Yang C et al. | Disruption of cholesterol homeostasis by plant sterols. | 2004 | J. Clin. Invest. | pmid:15372105 |
| Salen G et al. | Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia. | 2004 | Circulation | pmid:14769702 |
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| Awad AB et al. | Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. | 2003 | J. Nutr. Biochem. | pmid:12667603 |
| Chan DC et al. | Relationships between cholesterol homoeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndrome. | 2003 | Clin. Sci. | pmid:12653682 |
| Gorinstein S et al. | Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. | 2003 | J. Nutr. Biochem. | pmid:12742543 |
| von Bonsdorff-Nikander A et al. | Physical stability of a microcrystalline beta-sitosterol suspension in oil. | 2003 | Eur J Pharm Sci | pmid:12885381 |
| Ntanios FY et al. | Effects of various amounts of dietary plant sterol esters on plasma and hepatic sterol concentration and aortic foam cell formation of cholesterol-fed hamsters. | 2003 | Atherosclerosis | pmid:12860249 |
| Schaller H | The role of sterols in plant growth and development. | 2003 | Prog. Lipid Res. | pmid:12689617 |
| Chan DC et al. | Plasma markers of cholesterol homeostasis and apolipoprotein B-100 kinetics in the metabolic syndrome. | 2003 | Obes. Res. | pmid:12690090 |
| Graf GA et al. | ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. | 2003 | J. Biol. Chem. | pmid:14504269 |
| Marcone MF et al. | Amaranth as a rich dietary source of beta-sitosterol and other phytosterols. | 2003 | Plant Foods Hum Nutr | pmid:15366261 |
| Watts GF et al. | Effect of a statin on hepatic apolipoprotein B-100 secretion and plasma campesterol levels in the metabolic syndrome. | 2003 | Int. J. Obes. Relat. Metab. Disord. | pmid:12821974 |
| Mezine I et al. | Analysis of plant sterol and stanol esters in cholesterol-lowering spreads and beverages using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy. | 2003 | J. Agric. Food Chem. | pmid:12952413 |
| Miettinen TA et al. | Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. | 2003 | J. Lab. Clin. Med. | pmid:12577049 |
| Hendriks HF et al. | Safety of long-term consumption of plant sterol esters-enriched spread. | 2003 | Eur J Clin Nutr | pmid:12771969 |
| Lindenthal B et al. | Serum plant sterols and biliary cholesterol secretion in humans: studies with ursodeoxycholic acid. | 2002 | J. Lipid Res. | pmid:12091491 |
| Yu L et al. | Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12444248 |
| Clouse SD | Arabidopsis mutants reveal multiple roles for sterols in plant development. | 2002 | Plant Cell | pmid:12215500 |
| Sehayek E et al. | Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12446833 |
| Vanstone CA et al. | Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons. | 2002 | Am. J. Clin. Nutr. | pmid:12450893 |
| Khabazian I et al. | Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex. | 2002 | J. Neurochem. | pmid:12153476 |
| Nissinen M et al. | Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12016126 |
| Ostlund RE et al. | Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11882512 |
| Plat J and Mensink RP | Relationship of genetic variation in genes encoding apolipoprotein A-IV, scavenger receptor BI, HMG-CoA reductase, CETP and apolipoprotein E with cholesterol metabolism and the response to plant stanol ester consumption. | 2002 | Eur. J. Clin. Invest. | pmid:11952809 |
| Holmberg N et al. | Sterol C-24 methyltransferase type 1 controls the flux of carbon into sterol biosynthesis in tobacco seed. | 2002 | Plant Physiol. | pmid:12226510 |
| Hallikainen M et al. | Short-term LDL cholesterol-lowering efficacy of plant stanol esters. | 2002 | BMC Cardiovasc Disord | pmid:12197945 |
| Sudhop T et al. | Serum plant sterols as a potential risk factor for coronary heart disease. | 2002 | Metab. Clin. Exp. | pmid:12489060 |
| Ijzerman RG et al. | The association between low birth weight and high levels of cholesterol is not due to an increased cholesterol synthesis or absorption: analysis in twins. | 2002 | Pediatr. Res. | pmid:12438663 |
| Khripach VA et al. | [3,3]-Claisen rearrangements in 24alpha-methyl steroid synthesis. Application to campesterol, crinosterol, and Delta25-crinosterol side chain construction. | 2002 | Steroids | pmid:11996932 |
| De Graaf J et al. | Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. | 2002 | Br. J. Nutr. | pmid:12425728 |
| Sudhop T et al. | Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion. | 2002 | Gut | pmid:12427790 |