22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Teunissen CE et al. | Serum cholesterol, precursors and metabolites and cognitive performance in an aging population. | 2003 Jan-Feb | Neurobiol. Aging | pmid:12493560 |
| Miettinen TA et al. | Serum noncholesterol sterols during inhibition of cholesterol synthesis by statins. | 2003 | J. Lab. Clin. Med. | pmid:12577049 |
| Chan DC et al. | Relationships between cholesterol homoeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndrome. | 2003 | Clin. Sci. | pmid:12653682 |
| Awad AB et al. | Effect of phytosterols on cholesterol metabolism and MAP kinase in MDA-MB-231 human breast cancer cells. | 2003 | J. Nutr. Biochem. | pmid:12667603 |
| Schaller H | The role of sterols in plant growth and development. | 2003 | Prog. Lipid Res. | pmid:12689617 |
| Chan DC et al. | Plasma markers of cholesterol homeostasis and apolipoprotein B-100 kinetics in the metabolic syndrome. | 2003 | Obes. Res. | pmid:12690090 |
| Gorinstein S et al. | Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. | 2003 | J. Nutr. Biochem. | pmid:12742543 |
| Hendriks HF et al. | Safety of long-term consumption of plant sterol esters-enriched spread. | 2003 | Eur J Clin Nutr | pmid:12771969 |
| Watts GF et al. | Effect of a statin on hepatic apolipoprotein B-100 secretion and plasma campesterol levels in the metabolic syndrome. | 2003 | Int. J. Obes. Relat. Metab. Disord. | pmid:12821974 |
| Ntanios FY et al. | Effects of various amounts of dietary plant sterol esters on plasma and hepatic sterol concentration and aortic foam cell formation of cholesterol-fed hamsters. | 2003 | Atherosclerosis | pmid:12860249 |
| von Bonsdorff-Nikander A et al. | Physical stability of a microcrystalline beta-sitosterol suspension in oil. | 2003 | Eur J Pharm Sci | pmid:12885381 |
| Mezine I et al. | Analysis of plant sterol and stanol esters in cholesterol-lowering spreads and beverages using high-performance liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy. | 2003 | J. Agric. Food Chem. | pmid:12952413 |
| KALLIANOS AG et al. | Identification of the D-glucosides of stigmasterol, sitosterol and campesterol in tobacco and cigarette smoke. | 1963 | Biochem. J. | pmid:14030353 |
| Graf GA et al. | ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. | 2003 | J. Biol. Chem. | pmid:14504269 |
| Bloks VW et al. | Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes. | 2004 | Diabetologia | pmid:14618236 |
| Plösch T et al. | Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. | 2004 | Gastroenterology | pmid:14699507 |
| Devaraj S et al. | Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:14764424 |
| Salen G et al. | Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia. | 2004 | Circulation | pmid:14769702 |
| Nikkilä K et al. | Liver transplantation modifies serum cholestanol, cholesterol precursor and plant sterol levels. | 1992 | Clin. Chim. Acta | pmid:1499139 |
| Klett EL et al. | A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. | 2004 | BMC Med | pmid:15040800 |
| Ketomaki A et al. | Effects of plant stanol and sterol esters on serum phytosterols in a family with familial hypercholesterolemia including a homozygous subject. | 2004 | J. Lab. Clin. Med. | pmid:15085084 |
| Delaney B et al. | Oral absorption of phytosterols and emulsified phytosterols by Sprague-Dawley rats. | 2004 | J. Nutr. Biochem. | pmid:15135153 |
| Mongrand S et al. | Lipid rafts in higher plant cells: purification and characterization of Triton X-100-insoluble microdomains from tobacco plasma membrane. | 2004 | J. Biol. Chem. | pmid:15190066 |
| Amundsen AL et al. | Long-term compliance and changes in plasma lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol ester-enriched spread. | 2004 | Eur J Clin Nutr | pmid:15199384 |
| Vanhanen HT and Miettinen TA | Effects of unsaturated and saturated dietary plant sterols on their serum contents. | 1992 | Clin. Chim. Acta | pmid:1521345 |
| Tomoyori H et al. | Phytosterol oxidation products are absorbed in the intestinal lymphatics in rats but do not accelerate atherosclerosis in apolipoprotein E-deficient mice. | 2004 | J. Nutr. | pmid:15226455 |
| Nomura T et al. | Brassinosteroid deficiency due to truncated steroid 5alpha-reductase causes dwarfism in the lk mutant of pea. | 2004 | Plant Physiol. | pmid:15286289 |
| Pakarinen MP et al. | Growth hormone selectively improves intestinal cholesterol absorption after jejunoileal autotransplantation in pigs. | 2004 | J. Pediatr. Surg. | pmid:15300531 |
| Marcone MF et al. | Amaranth as a rich dietary source of beta-sitosterol and other phytosterols. | 2003 | Plant Foods Hum Nutr | pmid:15366261 |
| Yang C et al. | Disruption of cholesterol homeostasis by plant sterols. | 2004 | J. Clin. Invest. | pmid:15372105 |
| Lembcke J et al. | Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS/MS. | 2005 | J. Lipid Res. | pmid:15489546 |
| Plat J et al. | Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers. | 2005 | J. Lipid Res. | pmid:15520451 |
| Nikkilä K et al. | Sterol parameters as markers of liver function in primary biliary cirrhosis before and after liver transplantation. | 2005 | Transpl. Int. | pmid:15691276 |
| Yokosuka A et al. | New glycosides of the campesterol derivative from the rhizomes of Tacca chantrieri. | 2005 | Steroids | pmid:15784281 |
| Yu L et al. | Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8. | 2005 | J. Lipid Res. | pmid:15930515 |
| Miettinen TA et al. | Plant sterols in serum and in atherosclerotic plaques of patients undergoing carotid endarterectomy. | 2005 | J. Am. Coll. Cardiol. | pmid:15936608 |
| Hong Z et al. | The Rice brassinosteroid-deficient dwarf2 mutant, defective in the rice homolog of Arabidopsis DIMINUTO/DWARF1, is rescued by the endogenously accumulated alternative bioactive brassinosteroid, dolichosterone. | 2005 | Plant Cell | pmid:15994910 |
| Päivä H et al. | High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial. | 2005 | Clin. Pharmacol. Ther. | pmid:16003294 |
| Sutherland WH et al. | Plasma non-cholesterol sterols in patients with non-insulin dependent diabetes mellitus. | 1992 | Horm. Metab. Res. | pmid:1601392 |
| Awad AB et al. | beta-Sitosterol stimulates ceramide metabolism in differentiated Caco2 cells. | 2005 | J. Nutr. Biochem. | pmid:16098730 |
| Ho SS and Pal S | Margarine phytosterols decrease the secretion of atherogenic lipoproteins from HepG2 liver and Caco2 intestinal cells. | 2005 | Atherosclerosis | pmid:16115472 |
| Conchillo A et al. | Levels of phytosterol oxides in enriched and nonenriched spreads: application of a thin-layer chromatography-gas chromatography methodology. | 2005 | J. Agric. Food Chem. | pmid:16190640 |
| Xu F et al. | Dual roles for cholesterol in mammalian cells. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16199524 |
| Takahashi K et al. | Metabolic conversion of 24-methyl-Delta25-cholesterol to 24-methylcholesterol in higher plants. | 2006 | Bioorg. Med. Chem. | pmid:16213729 |
| de Jong A et al. | Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment. | 2006 | Eur J Clin Nutr | pmid:16482072 |
| Hedman M et al. | Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy. | 2006 | J. Pediatr. | pmid:16492436 |
| Takahashi K et al. | Purification and ATPase activity of human ABCA1. | 2006 | J. Biol. Chem. | pmid:16500904 |
| Sorenson WR and Sullivan D | Determination of campesterol, stigmasterol, and beta-sitosterol in saw palmetto raw materials and dietary supplements by gas chromatography: single-laboratory validation. | 2006 Jan-Feb | J AOAC Int | pmid:16512224 |
| Gerloff T et al. | Influence of the SLCO1B1*1b and *5 haplotypes on pravastatin's cholesterol lowering capabilities and basal sterol serum levels. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16568260 |
| Ikeda I et al. | Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats. | 2006 | Biochim. Biophys. Acta | pmid:16616424 |