22,23-dihydrobrassicasterol is a lipid of Sterol Lipids (ST) class. 22,23-dihydrobrassicasterol is associated with abnormalities such as Diabetes, Macular degeneration, Drusen, Systemic disease and Diabetes Mellitus. The involved functions are known as cholesterol metabolism, Synthesis, Intestinal Absorption, Liver function and cholesterol absorption. 22,23-dihydrobrassicasterol often locates in Back and Cell membrane. The associated genes with 22,23-dihydrobrassicasterol are apolipoprotein E-3. The related lipids are Total cholesterol, campesterol, lathosterol, Fatty Acids, Nonesterified and Cholesterol, Dietary.
To understand associated biological information of 22,23-dihydrobrassicasterol, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
22,23-dihydrobrassicasterol is suspected in Diabetes, Macular degeneration, Drusen, Systemic disease, Diabetes Mellitus, Liver diseases and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 22,23-dihydrobrassicasterol
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
| Hyperlipidemias | D006949 | 73 associated lipids |
| Hypolipoproteinemias | D007009 | 9 associated lipids |
| Xanthomatosis | D014973 | 17 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Weingärtner O et al. | Alterations in cholesterol homeostasis are associated with coronary heart disease in patients with aortic stenosis. | 2009 | Coron. Artery Dis. | pmid:19620855 |
| Assmann G et al. | Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe-statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia. | 2008 | Curr Med Res Opin | pmid:18053317 |
| Gylling H and Miettinen TA | Cholesterol absorption, synthesis, and LDL metabolism in NIDDM. | 1997 | Diabetes Care | pmid:9028702 |
| Ooi EM et al. | Plasma markers of cholesterol homeostasis in metabolic syndrome subjects with or without type-2 diabetes. | 2009 | Diabetes Res. Clin. Pract. | pmid:19573945 |
| Bloks VW et al. | Down-regulation of hepatic and intestinal Abcg5 and Abcg8 expression associated with altered sterol fluxes in rats with streptozotocin-induced diabetes. | 2004 | Diabetologia | pmid:14618236 |
| Koivisto PV and Miettinen TA | Effect of ileal exclusion on plant sterol metabolism in familial hypercholesterolemia. | 1987 | Digestion | pmid:3443223 |
| Okada K et al. | Lipid-lowering effects of ezetimibe for hypercholesterolemic patients with and without type 2 diabetes mellitus. | 2010 | Endocr. J. | pmid:20733267 |
| Hattori S and Hattori Y | Efficacy and safety of ezetimibe in patients undergoing hemodialysis. | 2010 | Endocr. J. | pmid:20885068 |
| Hendriks HF et al. | Safety of long-term consumption of plant sterol esters-enriched spread. | 2003 | Eur J Clin Nutr | pmid:12771969 |